Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy

Bea R H Van den Bergh, Marion I van den Heuvel, Marius Lahti, Marijke Braeken, Susanne R de Rooij, Sonja Entringer, Dirk Hoyer, Tessa Roseboom, Katri Räikkönen, Suzanne King, Matthias Schwab

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.

Original languageEnglish
JournalNeuroscience and Biobehavioral Reviews
DOIs
Publication statusE-pub ahead of print - 2019

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Mental Health
Mothers
Maternal Exposure
Nervous System
Gestational Age
Immune System

Cite this

Van den Bergh, Bea R H ; van den Heuvel, Marion I ; Lahti, Marius ; Braeken, Marijke ; de Rooij, Susanne R ; Entringer, Sonja ; Hoyer, Dirk ; Roseboom, Tessa ; Räikkönen, Katri ; King, Suzanne ; Schwab, Matthias. / Prenatal developmental origins of behavior and mental health : The influence of maternal stress in pregnancy. In: Neuroscience and Biobehavioral Reviews. 2019.
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abstract = "Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.",
author = "{Van den Bergh}, {Bea R H} and {van den Heuvel}, {Marion I} and Marius Lahti and Marijke Braeken and {de Rooij}, {Susanne R} and Sonja Entringer and Dirk Hoyer and Tessa Roseboom and Katri R{\"a}ikk{\"o}nen and Suzanne King and Matthias Schwab",
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year = "2019",
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language = "English",
journal = "Neuroscience and Biobehavioral Reviews",
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Prenatal developmental origins of behavior and mental health : The influence of maternal stress in pregnancy. / Van den Bergh, Bea R H; van den Heuvel, Marion I; Lahti, Marius; Braeken, Marijke; de Rooij, Susanne R; Entringer, Sonja; Hoyer, Dirk; Roseboom, Tessa; Räikkönen, Katri; King, Suzanne; Schwab, Matthias.

In: Neuroscience and Biobehavioral Reviews, 2019.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Prenatal developmental origins of behavior and mental health

T2 - The influence of maternal stress in pregnancy

AU - Van den Bergh, Bea R H

AU - van den Heuvel, Marion I

AU - Lahti, Marius

AU - Braeken, Marijke

AU - de Rooij, Susanne R

AU - Entringer, Sonja

AU - Hoyer, Dirk

AU - Roseboom, Tessa

AU - Räikkönen, Katri

AU - King, Suzanne

AU - Schwab, Matthias

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.

AB - Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.

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JO - Neuroscience and Biobehavioral Reviews

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SN - 0149-7634

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