Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: A cross-sectional study from the PROFILES registry

M.J.A. Rietveld, O. Husson, M.C.C. Vos, L.V. van der Poll-Franse, P.B.N. Ottevanger, N.P.M. Ezendam

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Abstract

Objective
To assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors.

Methods
Women diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on socio-demographic characteristics, HRQoL (EORTC-QLQ-C30), ovarian cancer-specific symptoms including GI (EORTC-QLQ OV28), and psychological distress (HADS). Data collection took place in 2012.

Results
Of 348 women diagnosed with ovarian cancer, 191 (55%) responded. Of all participants, 69% were eligible for analysis (n = 131). In 25% of all women, high level GI symptoms occurred (n = 33). In 23% of all women, recurrence of OC occurred (n = 30). Regression analysis showed that presence of high levels of GI symptoms during survivorship was associated with lower functioning on all HRQoL domains (except for emotional functioning), more symptoms, and higher levels of distress. QoL was negatively affected in those who had few and high levels of GI symptoms. QoL of those with recurrent disease was worse than those without recurrent disease.

Conclusion
A substantial proportion of OC survivors experience GI symptoms, regardless of the recurrence of disease. Health care professionals should be aware of GI symptoms during survivorship in order to refer their patients for supportive care interventions to reduce symptoms or help survivors to cope. Further research should examine the cause of GI symptoms during OC survivorship among those with non-recurrent disease
Original languageEnglish
Pages (from-to)2285-2293
Number of pages9
JournalSupportive Care in Cancer
Volume27
Issue number6
Early online date2019
DOIs
Publication statusPublished - Jun 2019

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Ovarian Neoplasms
Survival Rate
Cross-Sectional Studies
Survivors
Netherlands
Delivery of Health Care
Neoplasms

Keywords

  • CLINICAL-TRIALS
  • DEPRESSION SCALE
  • Gastro-intestinal symptoms
  • HEALTH
  • HOSPITAL ANXIETY
  • MANAGEMENT
  • OUTCOMES
  • Ovarian cancer
  • QUALITY-OF-LIFE
  • QUESTIONNAIRE
  • Survivorship

Cite this

@article{3387809e2bc14c7bbe683ad7d911a9fa,
title = "Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: A cross-sectional study from the PROFILES registry",
abstract = "ObjectiveTo assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors.MethodsWomen diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on socio-demographic characteristics, HRQoL (EORTC-QLQ-C30), ovarian cancer-specific symptoms including GI (EORTC-QLQ OV28), and psychological distress (HADS). Data collection took place in 2012.ResultsOf 348 women diagnosed with ovarian cancer, 191 (55{\%}) responded. Of all participants, 69{\%} were eligible for analysis (n = 131). In 25{\%} of all women, high level GI symptoms occurred (n = 33). In 23{\%} of all women, recurrence of OC occurred (n = 30). Regression analysis showed that presence of high levels of GI symptoms during survivorship was associated with lower functioning on all HRQoL domains (except for emotional functioning), more symptoms, and higher levels of distress. QoL was negatively affected in those who had few and high levels of GI symptoms. QoL of those with recurrent disease was worse than those without recurrent disease.ConclusionA substantial proportion of OC survivors experience GI symptoms, regardless of the recurrence of disease. Health care professionals should be aware of GI symptoms during survivorship in order to refer their patients for supportive care interventions to reduce symptoms or help survivors to cope. Further research should examine the cause of GI symptoms during OC survivorship among those with non-recurrent disease",
keywords = "CLINICAL-TRIALS, DEPRESSION SCALE, Gastro-intestinal symptoms, HEALTH, HOSPITAL ANXIETY, MANAGEMENT, OUTCOMES, Ovarian cancer, QUALITY-OF-LIFE, QUESTIONNAIRE, Survivorship",
author = "M.J.A. Rietveld and O. Husson and M.C.C. Vos and {van der Poll-Franse}, L.V. and P.B.N. Ottevanger and N.P.M. Ezendam",
year = "2019",
month = "6",
doi = "10.1007/s00520-018-4510-9",
language = "English",
volume = "27",
pages = "2285--2293",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "6",

}

Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship : A cross-sectional study from the PROFILES registry. / Rietveld, M.J.A.; Husson, O.; Vos, M.C.C.; van der Poll-Franse, L.V.; Ottevanger, P.B.N.; Ezendam, N.P.M.

In: Supportive Care in Cancer, Vol. 27, No. 6, 06.2019, p. 2285-2293.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship

T2 - A cross-sectional study from the PROFILES registry

AU - Rietveld, M.J.A.

AU - Husson, O.

AU - Vos, M.C.C.

AU - van der Poll-Franse, L.V.

AU - Ottevanger, P.B.N.

AU - Ezendam, N.P.M.

PY - 2019/6

Y1 - 2019/6

N2 - ObjectiveTo assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors.MethodsWomen diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on socio-demographic characteristics, HRQoL (EORTC-QLQ-C30), ovarian cancer-specific symptoms including GI (EORTC-QLQ OV28), and psychological distress (HADS). Data collection took place in 2012.ResultsOf 348 women diagnosed with ovarian cancer, 191 (55%) responded. Of all participants, 69% were eligible for analysis (n = 131). In 25% of all women, high level GI symptoms occurred (n = 33). In 23% of all women, recurrence of OC occurred (n = 30). Regression analysis showed that presence of high levels of GI symptoms during survivorship was associated with lower functioning on all HRQoL domains (except for emotional functioning), more symptoms, and higher levels of distress. QoL was negatively affected in those who had few and high levels of GI symptoms. QoL of those with recurrent disease was worse than those without recurrent disease.ConclusionA substantial proportion of OC survivors experience GI symptoms, regardless of the recurrence of disease. Health care professionals should be aware of GI symptoms during survivorship in order to refer their patients for supportive care interventions to reduce symptoms or help survivors to cope. Further research should examine the cause of GI symptoms during OC survivorship among those with non-recurrent disease

AB - ObjectiveTo assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors.MethodsWomen diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on socio-demographic characteristics, HRQoL (EORTC-QLQ-C30), ovarian cancer-specific symptoms including GI (EORTC-QLQ OV28), and psychological distress (HADS). Data collection took place in 2012.ResultsOf 348 women diagnosed with ovarian cancer, 191 (55%) responded. Of all participants, 69% were eligible for analysis (n = 131). In 25% of all women, high level GI symptoms occurred (n = 33). In 23% of all women, recurrence of OC occurred (n = 30). Regression analysis showed that presence of high levels of GI symptoms during survivorship was associated with lower functioning on all HRQoL domains (except for emotional functioning), more symptoms, and higher levels of distress. QoL was negatively affected in those who had few and high levels of GI symptoms. QoL of those with recurrent disease was worse than those without recurrent disease.ConclusionA substantial proportion of OC survivors experience GI symptoms, regardless of the recurrence of disease. Health care professionals should be aware of GI symptoms during survivorship in order to refer their patients for supportive care interventions to reduce symptoms or help survivors to cope. Further research should examine the cause of GI symptoms during OC survivorship among those with non-recurrent disease

KW - CLINICAL-TRIALS

KW - DEPRESSION SCALE

KW - Gastro-intestinal symptoms

KW - HEALTH

KW - HOSPITAL ANXIETY

KW - MANAGEMENT

KW - OUTCOMES

KW - Ovarian cancer

KW - QUALITY-OF-LIFE

KW - QUESTIONNAIRE

KW - Survivorship

U2 - 10.1007/s00520-018-4510-9

DO - 10.1007/s00520-018-4510-9

M3 - Article

VL - 27

SP - 2285

EP - 2293

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 6

ER -