TY - JOUR
T1 - Prognostic factors for recovery of health status after injury
T2 - A prospective multicentre cohort study
AU - De Munter, L.
AU - Polinder, S.
AU - Havermans, R.J.M.
AU - Steyerberg, E.W.
AU - De Jongh, M.A.C.
N1 - Data availability statement: Data are available upon reasonable request. Data from this study can contain potentially identifying or sensitive patient information. Data are anonymised, but due to relatively few severe cases, patients could be identified. Therefore, data from the BIOS Study will be made available for researchers who provide a methodologically sound proposal. Requests may be sent to [email protected].
PY - 2021/1/6
Y1 - 2021/1/6
N2 - Objectives To determine prognostic factors for health status and recovery patterns during the first 2 years after injury in the clinical trauma population. Design A prospective longitudinal cohort study. Setting Ten participating hospitals in Brabant, the Netherlands. Participants Injured adult patients admitted to a hospital between August 2015 and November 2016 were followed: 4883 (50%) patients participated. Main outcome measures Primary outcome was health status, measured with the EuroQol-5-dimensions-3-levels (EQ-5D), including a cognition item and the EuroQol Visual Analogue Scale. Health status was collected at 1 week, 1, 3, 6, 12 and 24 months after injury. Potential prognostic factors were based on literature and clinical experience (eg, age, sex, pre-injury frailty (Groningen Frailty Index), pre-injury EQ-5D). Results Health status increased mainly during the first 6months after injury with a mean EQ-5D utility score at 1 week of 0.49 and 0.79 at 24 months. The dimensions mobility, pain/discomfort and usual activities improved up to 2 years after injury. Lower pre-injury health status, frailty and longer length of stay at the hospital were important prognostic factors for poor recovery. Spine injury, lower and upper extremity injury showed to be prognostic factors for problems after injury. Traumatic brain injury was a prognostic factor for cognitive problems. Conclusion This study contributes to the increase in knowledge of health recovery after injury. It could be a starting point to develop prediction models for specific injury classifications and implementation of personalised medicine. Trial registration number NCT02508675.
AB - Objectives To determine prognostic factors for health status and recovery patterns during the first 2 years after injury in the clinical trauma population. Design A prospective longitudinal cohort study. Setting Ten participating hospitals in Brabant, the Netherlands. Participants Injured adult patients admitted to a hospital between August 2015 and November 2016 were followed: 4883 (50%) patients participated. Main outcome measures Primary outcome was health status, measured with the EuroQol-5-dimensions-3-levels (EQ-5D), including a cognition item and the EuroQol Visual Analogue Scale. Health status was collected at 1 week, 1, 3, 6, 12 and 24 months after injury. Potential prognostic factors were based on literature and clinical experience (eg, age, sex, pre-injury frailty (Groningen Frailty Index), pre-injury EQ-5D). Results Health status increased mainly during the first 6months after injury with a mean EQ-5D utility score at 1 week of 0.49 and 0.79 at 24 months. The dimensions mobility, pain/discomfort and usual activities improved up to 2 years after injury. Lower pre-injury health status, frailty and longer length of stay at the hospital were important prognostic factors for poor recovery. Spine injury, lower and upper extremity injury showed to be prognostic factors for problems after injury. Traumatic brain injury was a prognostic factor for cognitive problems. Conclusion This study contributes to the increase in knowledge of health recovery after injury. It could be a starting point to develop prediction models for specific injury classifications and implementation of personalised medicine. Trial registration number NCT02508675.
UR - https://www.scopus.com/pages/publications/85099129133
U2 - 10.1136/bmjopen-2020-038707
DO - 10.1136/bmjopen-2020-038707
M3 - Article
C2 - 33408198
SN - 2044-6055
VL - 11
JO - BMJ Open
JF - BMJ Open
M1 - e038707
ER -