Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Anne E. Justice, Tugce Karaderi, Heather M. Highland, Kristin L. Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L. Auer, Rebecca S. Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W. Winkler, Adam E. Locke, Carolina Medina-gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri & 259 others Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie C. Y. Ng, Nancy L. Heard-costa, Mary F. Feitosa, Alisa K. Manning, Sara M. Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S. Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F. Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A. Böger, Jette Bork-jensen, Erwin P. Bottinger, Donald W. Bowden, Ivan Brandslund, Linda Broer, Amber A. Burt, Adam S. Butterworth, Mark J. Caulfield, Giancarlo Cesana, John C. Chambers, Daniel I. Chasman, Yii-der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y. Chu, Francis S. Collins, James P. Cook, Amanda J. Cox, David S. Crosslin, John Danesh, Paul I. W. De Bakker, Simon De Denus, Renée De Mutsert, George Dedoussis, Ellen W. Demerath, Joe G. Dennis, Josh C. Denny, Emanuele Di Angelantonio, Marcus Dörr, Fotios Drenos, Marie-pierre Dubé, Alison M. Dunning, Douglas F. Easton, Paul Elliott, Evangelos Evangelou, Aliki-eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C. Florez, Myriam Fornage, Caroline S. Fox, Paul W. Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L. Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T. Hattersley, Caroline Hayward, Iris M. Heid, Oddgeir L. Holmen, G. Kees Hovingh, Joanna M. M. Howson, Yao Hu, Yi-jen Hung, Kristian Hveem, M. Arfan Ikram, Erik Ingelsson, Anne U. Jackson, Gail P. Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M. Justesen, Bratati Kahali, Maria Karaleftheri, Sharon L. R. Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S. Kooner, Peter Kovacs, Bernhard K. Krämer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, David Lamparter, Leslie A. Lange, Claudia Langenberg, Eric B. Larson, Nanette R. Lee, Wen-jane Lee, Terho Lehtimäki, Cora E. Lewis, Huaixing Li, Jin Li, Ruifang Li-gao, Li-an Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-ti Liu, Dajiang J. Liu, Jian’an Luan, Leo-pekka Lyytikäinen, Stuart Macgregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas G. D. Masca, Mark I. Mccarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O. Mook-kanamori, Anna Morgan, Andrew P. Morris, Martina Müller-nurasyid, Patricia B. Munroe, Narisu Narisu, Christopher P. Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R. O’connell, Katharine R. Owen, Oluf Pedersen, Gina M. Peloso, Craig E. Pennell, Markus Perola, James A. Perry, John R. B. Perry, Tune H. Pers, Ailith Ewing, Ozren Polasek, Olli T. Raitakari, Asif Rasheed, Chelsea K. Raulerson, Rainer Rauramaa, Dermot F. Reilly, Alex P. Reiner, Paul M. Ridker, Manuel A. Rivas, Neil R. Robertson, Antonietta Robino, Igor Rudan, Katherine S. Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J. Samani, Pamela J. Schreiner, Matthias B. Schulze, Robert A. Scott, Marcelo Segura-lepe, Xueling Sim, Andrew J. Slater, Kerrin S. Small, Blair H. Smith, Jennifer A. Smith, Lorraine Southam, Timothy D. Spector, Elizabeth K. Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E. Stirrups, Konstantin Strauch, Heather M. Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin M. A. Swart, Jean-claude Tardif, Kent D. Taylor, Alexander Teumer, Deborah J. Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H. Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Cornelia M. Van Duijn, Mauno Vanhala, Rohit Varma, Sita H. Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F. Vogt, Dragana Vuckovic, Lynne E. Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A. Wang, Shuai Wang, Nicholas J. Wareham, Helen R. Warren, Dawn M. Waterworth, Jennifer Wessel, Harvey D. White, Cristen J. Willer, James G. Wilson, Andrew R. Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M. Yerges-armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M. Carola Zillikens, Fernando Rivadeneira, Ingrid B. Borecki, J. Andrew Pospisilik, Panos Deloukas, Timothy M. Frayling, Guillaume Lettre, Karen L. Mohlke, Jerome I. Rotter, Zoltán Kutalik, Joel N. Hirschhorn, L. Adrienne Cupples, Ruth J. F. Loos, Kari E. North, Cecilia M. Lindgren

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF
Original languageEnglish
Pages (from-to)452-469
JournalNature Genetics
Volume51
Issue number3
DOIs
Publication statusPublished - 2019

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Homeostasis
Exome
Lipids
Body Mass Index

Keywords

  • Animals
  • Body Fat Distribution/methods
  • Body Mass Index
  • Case-Control Studies
  • Drosophila/genetics
  • Exome/genetics
  • Female
  • Gene Frequency/genetics
  • Genetic Predisposition to Disease/genetics
  • Genetic Variation/genetics
  • Genome-Wide Association Study/methods
  • Homeostasis/genetics
  • Humans
  • Lipids/genetics
  • Male
  • Proteins/genetics
  • Risk Factors
  • Waist-Hip Ratio/methods
  • ABDOMINAL ADIPOSITY
  • KINASE 7
  • RS11209026 POLYMORPHISM
  • INSULIN-RESISTANCE
  • ADIPOCYTE DIFFERENTIATION
  • ADIPOSE-TISSUE
  • GENOME-WIDE ASSOCIATION
  • TYPE-2 DIABETES SUSCEPTIBILITY
  • WAIST CIRCUMFERENCE
  • RECEPTOR ALK7

Cite this

Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., ... Lindgren, C. M. (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51(3), 452-469. https://doi.org/10.1038/s41588-018-0334-2
Justice, Anne E. ; Karaderi, Tugce ; Highland, Heather M. ; Young, Kristin L. ; Graff, Mariaelisa ; Lu, Yingchang ; Turcot, Valérie ; Auer, Paul L. ; Fine, Rebecca S. ; Guo, Xiuqing ; Schurmann, Claudia ; Lempradl, Adelheid ; Marouli, Eirini ; Mahajan, Anubha ; Winkler, Thomas W. ; Locke, Adam E. ; Medina-gomez, Carolina ; Esko, Tõnu ; Vedantam, Sailaja ; Giri, Ayush ; Lo, Ken Sin ; Alfred, Tamuno ; Mudgal, Poorva ; Ng, Maggie C. Y. ; Heard-costa, Nancy L. ; Feitosa, Mary F. ; Manning, Alisa K. ; Willems, Sara M. ; Sivapalaratnam, Suthesh ; Abecasis, Goncalo ; Alam, Dewan S. ; Allison, Matthew ; Amouyel, Philippe ; Arzumanyan, Zorayr ; Balkau, Beverley ; Bastarache, Lisa ; Bergmann, Sven ; Bielak, Lawrence F. ; Blüher, Matthias ; Boehnke, Michael ; Boeing, Heiner ; Boerwinkle, Eric ; Böger, Carsten A. ; Bork-jensen, Jette ; Bottinger, Erwin P. ; Bowden, Donald W. ; Brandslund, Ivan ; Broer, Linda ; Burt, Amber A. ; Butterworth, Adam S. ; Caulfield, Mark J. ; Cesana, Giancarlo ; Chambers, John C. ; Chasman, Daniel I. ; Chen, Yii-der Ida ; Chowdhury, Rajiv ; Christensen, Cramer ; Chu, Audrey Y. ; Collins, Francis S. ; Cook, James P. ; Cox, Amanda J. ; Crosslin, David S. ; Danesh, John ; De Bakker, Paul I. W. ; Denus, Simon De ; Mutsert, Renée De ; Dedoussis, George ; Demerath, Ellen W. ; Dennis, Joe G. ; Denny, Josh C. ; Di Angelantonio, Emanuele ; Dörr, Marcus ; Drenos, Fotios ; Dubé, Marie-pierre ; Dunning, Alison M. ; Easton, Douglas F. ; Elliott, Paul ; Evangelou, Evangelos ; Farmaki, Aliki-eleni ; Feng, Shuang ; Ferrannini, Ele ; Ferrieres, Jean ; Florez, Jose C. ; Fornage, Myriam ; Fox, Caroline S. ; Franks, Paul W. ; Friedrich, Nele ; Gan, Wei ; Gandin, Ilaria ; Gasparini, Paolo ; Giedraitis, Vilmantas ; Girotto, Giorgia ; Gorski, Mathias ; Grallert, Harald ; Grarup, Niels ; Grove, Megan L. ; Gustafsson, Stefan ; Haessler, Jeff ; Hansen, Torben ; Hattersley, Andrew T. ; Hayward, Caroline ; Heid, Iris M. ; Holmen, Oddgeir L. ; Hovingh, G. Kees ; Howson, Joanna M. M. ; Hu, Yao ; Hung, Yi-jen ; Hveem, Kristian ; Ikram, M. Arfan ; Ingelsson, Erik ; Jackson, Anne U. ; Jarvik, Gail P. ; Jia, Yucheng ; Jørgensen, Torben ; Jousilahti, Pekka ; Justesen, Johanne M. ; Kahali, Bratati ; Karaleftheri, Maria ; Kardia, Sharon L. R. ; Karpe, Fredrik ; Kee, Frank ; Kitajima, Hidetoshi ; Komulainen, Pirjo ; Kooner, Jaspal S. ; Kovacs, Peter ; Krämer, Bernhard K. ; Kuulasmaa, Kari ; Kuusisto, Johanna ; Laakso, Markku ; Lakka, Timo A. ; Lamparter, David ; Lange, Leslie A. ; Langenberg, Claudia ; Larson, Eric B. ; Lee, Nanette R. ; Lee, Wen-jane ; Lehtimäki, Terho ; Lewis, Cora E. ; Li, Huaixing ; Li, Jin ; Li-gao, Ruifang ; Lin, Li-an ; Lin, Xu ; Lind, Lars ; Lindström, Jaana ; Linneberg, Allan ; Liu, Ching-ti ; Liu, Dajiang J. ; Luan, Jian’an ; Lyytikäinen, Leo-pekka ; Macgregor, Stuart ; Mägi, Reedik ; Männistö, Satu ; Marenne, Gaëlle ; Marten, Jonathan ; Masca, Nicholas G. D. ; Mccarthy, Mark I. ; Meidtner, Karina ; Mihailov, Evelin ; Moilanen, Leena ; Moitry, Marie ; Mook-kanamori, Dennis O. ; Morgan, Anna ; Morris, Andrew P. ; Müller-nurasyid, Martina ; Munroe, Patricia B. ; Narisu, Narisu ; Nelson, Christopher P. ; Neville, Matt ; Ntalla, Ioanna ; O’connell, Jeffrey R. ; Owen, Katharine R. ; Pedersen, Oluf ; Peloso, Gina M. ; Pennell, Craig E. ; Perola, Markus ; Perry, James A. ; Perry, John R. B. ; Pers, Tune H. ; Ewing, Ailith ; Polasek, Ozren ; Raitakari, Olli T. ; Rasheed, Asif ; Raulerson, Chelsea K. ; Rauramaa, Rainer ; Reilly, Dermot F. ; Reiner, Alex P. ; Ridker, Paul M. ; Rivas, Manuel A. ; Robertson, Neil R. ; Robino, Antonietta ; Rudan, Igor ; Ruth, Katherine S. ; Saleheen, Danish ; Salomaa, Veikko ; Samani, Nilesh J. ; Schreiner, Pamela J. ; Schulze, Matthias B. ; Scott, Robert A. ; Segura-lepe, Marcelo ; Sim, Xueling ; Slater, Andrew J. ; Small, Kerrin S. ; Smith, Blair H. ; Smith, Jennifer A. ; Southam, Lorraine ; Spector, Timothy D. ; Speliotes, Elizabeth K. ; Stefansson, Kari ; Steinthorsdottir, Valgerdur ; Stirrups, Kathleen E. ; Strauch, Konstantin ; Stringham, Heather M. ; Stumvoll, Michael ; Sun, Liang ; Surendran, Praveen ; Swart, Karin M. A. ; Tardif, Jean-claude ; Taylor, Kent D. ; Teumer, Alexander ; Thompson, Deborah J. ; Thorleifsson, Gudmar ; Thorsteinsdottir, Unnur ; Thuesen, Betina H. ; Tönjes, Anke ; Torres, Mina ; Tsafantakis, Emmanouil ; Tuomilehto, Jaakko ; Uitterlinden, André G. ; Uusitupa, Matti ; Van Duijn, Cornelia M. ; Vanhala, Mauno ; Varma, Rohit ; Vermeulen, Sita H. ; Vestergaard, Henrik ; Vitart, Veronique ; Vogt, Thomas F. ; Vuckovic, Dragana ; Wagenknecht, Lynne E. ; Walker, Mark ; Wallentin, Lars ; Wang, Feijie ; Wang, Carol A. ; Wang, Shuai ; Wareham, Nicholas J. ; Warren, Helen R. ; Waterworth, Dawn M. ; Wessel, Jennifer ; White, Harvey D. ; Willer, Cristen J. ; Wilson, James G. ; Wood, Andrew R. ; Wu, Ying ; Yaghootkar, Hanieh ; Yao, Jie ; Yerges-armstrong, Laura M. ; Young, Robin ; Zeggini, Eleftheria ; Zhan, Xiaowei ; Zhang, Weihua ; Zhao, Jing Hua ; Zhao, Wei ; Zheng, He ; Zhou, Wei ; Zillikens, M. Carola ; Rivadeneira, Fernando ; Borecki, Ingrid B. ; Pospisilik, J. Andrew ; Deloukas, Panos ; Frayling, Timothy M. ; Lettre, Guillaume ; Mohlke, Karen L. ; Rotter, Jerome I. ; Kutalik, Zoltán ; Hirschhorn, Joel N. ; Cupples, L. Adrienne ; Loos, Ruth J. F. ; North, Kari E. ; Lindgren, Cecilia M. / Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. In: Nature Genetics. 2019 ; Vol. 51, No. 3. pp. 452-469.
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abstract = "Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5{\%}) and nine low-frequency or rare (MAF",
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author = "Justice, {Anne E.} and Tugce Karaderi and Highland, {Heather M.} and Young, {Kristin L.} and Mariaelisa Graff and Yingchang Lu and Val{\'e}rie Turcot and Auer, {Paul L.} and Fine, {Rebecca S.} and Xiuqing Guo and Claudia Schurmann and Adelheid Lempradl and Eirini Marouli and Anubha Mahajan and Winkler, {Thomas W.} and Locke, {Adam E.} and Carolina Medina-gomez and T{\~o}nu Esko and Sailaja Vedantam and Ayush Giri and Lo, {Ken Sin} and Tamuno Alfred and Poorva Mudgal and Ng, {Maggie C. Y.} and Heard-costa, {Nancy L.} and Feitosa, {Mary F.} and Manning, {Alisa K.} and Willems, {Sara M.} and Suthesh Sivapalaratnam and Goncalo Abecasis and Alam, {Dewan S.} and Matthew Allison and Philippe Amouyel and Zorayr Arzumanyan and Beverley Balkau and Lisa Bastarache and Sven Bergmann and Bielak, {Lawrence F.} and Matthias Bl{\"u}her and Michael Boehnke and Heiner Boeing and Eric Boerwinkle and B{\"o}ger, {Carsten A.} and Jette Bork-jensen and Bottinger, {Erwin P.} and Bowden, {Donald W.} and Ivan Brandslund and Linda Broer and Burt, {Amber A.} and Butterworth, {Adam S.} and Caulfield, {Mark J.} and Giancarlo Cesana and Chambers, {John C.} and Chasman, {Daniel I.} and Chen, {Yii-der Ida} and Rajiv Chowdhury and Cramer Christensen and Chu, {Audrey Y.} and Collins, {Francis S.} and Cook, {James P.} and Cox, {Amanda J.} and Crosslin, {David S.} and John Danesh and {De Bakker}, {Paul I. W.} and Denus, {Simon De} and Mutsert, {Ren{\'e}e De} and George Dedoussis and Demerath, {Ellen W.} and Dennis, {Joe G.} and Denny, {Josh C.} and {Di Angelantonio}, Emanuele and Marcus D{\"o}rr and Fotios Drenos and Marie-pierre Dub{\'e} and Dunning, {Alison M.} and Easton, {Douglas F.} and Paul Elliott and Evangelos Evangelou and Aliki-eleni Farmaki and Shuang Feng and Ele Ferrannini and Jean Ferrieres and Florez, {Jose C.} and Myriam Fornage and Fox, {Caroline S.} and Franks, {Paul W.} and Nele Friedrich and Wei Gan and Ilaria Gandin and Paolo Gasparini and Vilmantas Giedraitis and Giorgia Girotto and Mathias Gorski and Harald Grallert and Niels Grarup and Grove, {Megan L.} and Stefan Gustafsson and Jeff Haessler and Torben Hansen and Hattersley, {Andrew T.} and Caroline Hayward and Heid, {Iris M.} and Holmen, {Oddgeir L.} and Hovingh, {G. Kees} and Howson, {Joanna M. M.} and Yao Hu and Yi-jen Hung and Kristian Hveem and Ikram, {M. Arfan} and Erik Ingelsson and Jackson, {Anne U.} and Jarvik, {Gail P.} and Yucheng Jia and Torben J{\o}rgensen and Pekka Jousilahti and Justesen, {Johanne M.} and Bratati Kahali and Maria Karaleftheri and Kardia, {Sharon L. R.} and Fredrik Karpe and Frank Kee and Hidetoshi Kitajima and Pirjo Komulainen and Kooner, {Jaspal S.} and Peter Kovacs and Kr{\"a}mer, {Bernhard K.} and Kari Kuulasmaa and Johanna Kuusisto and Markku Laakso and Lakka, {Timo A.} and David Lamparter and Lange, {Leslie A.} and Claudia Langenberg and Larson, {Eric B.} and Lee, {Nanette R.} and Wen-jane Lee and Terho Lehtim{\"a}ki and Lewis, {Cora E.} and Huaixing Li and Jin Li and Ruifang Li-gao and Li-an Lin and Xu Lin and Lars Lind and Jaana Lindstr{\"o}m and Allan Linneberg and Ching-ti Liu and Liu, {Dajiang J.} and Jian’an Luan and Leo-pekka Lyytik{\"a}inen and Stuart Macgregor and Reedik M{\"a}gi and Satu M{\"a}nnist{\"o} and Ga{\"e}lle Marenne and Jonathan Marten and Masca, {Nicholas G. D.} and Mccarthy, {Mark I.} and Karina Meidtner and Evelin Mihailov and Leena Moilanen and Marie Moitry and Mook-kanamori, {Dennis O.} and Anna Morgan and Morris, {Andrew P.} and Martina M{\"u}ller-nurasyid and Munroe, {Patricia B.} and Narisu Narisu and Nelson, {Christopher P.} and Matt Neville and Ioanna Ntalla and O’connell, {Jeffrey R.} and Owen, {Katharine R.} and Oluf Pedersen and Peloso, {Gina M.} and Pennell, {Craig E.} and Markus Perola and Perry, {James A.} and Perry, {John R. B.} and Pers, {Tune H.} and Ailith Ewing and Ozren Polasek and Raitakari, {Olli T.} and Asif Rasheed and Raulerson, {Chelsea K.} and Rainer Rauramaa and Reilly, {Dermot F.} and Reiner, {Alex P.} and Ridker, {Paul M.} and Rivas, {Manuel A.} and Robertson, {Neil R.} and Antonietta Robino and Igor Rudan and Ruth, {Katherine S.} and Danish Saleheen and Veikko Salomaa and Samani, {Nilesh J.} and Schreiner, {Pamela J.} and Schulze, {Matthias B.} and Scott, {Robert A.} and Marcelo Segura-lepe and Xueling Sim and Slater, {Andrew J.} and Small, {Kerrin S.} and Smith, {Blair H.} and Smith, {Jennifer A.} and Lorraine Southam and Spector, {Timothy D.} and Speliotes, {Elizabeth K.} and Kari Stefansson and Valgerdur Steinthorsdottir and Stirrups, {Kathleen E.} and Konstantin Strauch and Stringham, {Heather M.} and Michael Stumvoll and Liang Sun and Praveen Surendran and Swart, {Karin M. A.} and Jean-claude Tardif and Taylor, {Kent D.} and Alexander Teumer and Thompson, {Deborah J.} and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Thuesen, {Betina H.} and Anke T{\"o}njes and Mina Torres and Emmanouil Tsafantakis and Jaakko Tuomilehto and Uitterlinden, {Andr{\'e} G.} and Matti Uusitupa and {Van Duijn}, {Cornelia M.} and Mauno Vanhala and Rohit Varma and Vermeulen, {Sita H.} and Henrik Vestergaard and Veronique Vitart and Vogt, {Thomas F.} and Dragana Vuckovic and Wagenknecht, {Lynne E.} and Mark Walker and Lars Wallentin and Feijie Wang and Wang, {Carol A.} and Shuai Wang and Wareham, {Nicholas J.} and Warren, {Helen R.} and Waterworth, {Dawn M.} and Jennifer Wessel and White, {Harvey D.} and Willer, {Cristen J.} and Wilson, {James G.} and Wood, {Andrew R.} and Ying Wu and Hanieh Yaghootkar and Jie Yao and Yerges-armstrong, {Laura M.} and Robin Young and Eleftheria Zeggini and Xiaowei Zhan and Weihua Zhang and Zhao, {Jing Hua} and Wei Zhao and He Zheng and Wei Zhou and Zillikens, {M. Carola} and Fernando Rivadeneira and Borecki, {Ingrid B.} and Pospisilik, {J. Andrew} and Panos Deloukas and Frayling, {Timothy M.} and Guillaume Lettre and Mohlke, {Karen L.} and Rotter, {Jerome I.} and Zolt{\'a}n Kutalik and Hirschhorn, {Joel N.} and Cupples, {L. Adrienne} and Loos, {Ruth J. F.} and North, {Kari E.} and Lindgren, {Cecilia M.}",
year = "2019",
doi = "10.1038/s41588-018-0334-2",
language = "English",
volume = "51",
pages = "452--469",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "3",

}

Justice, AE, Karaderi, T, Highland, HM, Young, KL, Graff, M, Lu, Y, Turcot, V, Auer, PL, Fine, RS, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, TW, Locke, AE, Medina-gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, KS, Alfred, T, Mudgal, P, Ng, MCY, Heard-costa, NL, Feitosa, MF, Manning, AK, Willems, SM, Sivapalaratnam, S, Abecasis, G, Alam, DS, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, LF, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, CA, Bork-jensen, J, Bottinger, EP, Bowden, DW, Brandslund, I, Broer, L, Burt, AA, Butterworth, AS, Caulfield, MJ, Cesana, G, Chambers, JC, Chasman, DI, Chen, YI, Chowdhury, R, Christensen, C, Chu, AY, Collins, FS, Cook, JP, Cox, AJ, Crosslin, DS, Danesh, J, De Bakker, PIW, Denus, SD, Mutsert, RD, Dedoussis, G, Demerath, EW, Dennis, JG, Denny, JC, Di Angelantonio, E, Dörr, M, Drenos, F, Dubé, M, Dunning, AM, Easton, DF, Elliott, P, Evangelou, E, Farmaki, A, Feng, S, Ferrannini, E, Ferrieres, J, Florez, JC, Fornage, M, Fox, CS, Franks, PW, Friedrich, N, Gan, W, Gandin, I, Gasparini, P, Giedraitis, V, Girotto, G, Gorski, M, Grallert, H, Grarup, N, Grove, ML, Gustafsson, S, Haessler, J, Hansen, T, Hattersley, AT, Hayward, C, Heid, IM, Holmen, OL, Hovingh, GK, Howson, JMM, Hu, Y, Hung, Y, Hveem, K, Ikram, MA, Ingelsson, E, Jackson, AU, Jarvik, GP, Jia, Y, Jørgensen, T, Jousilahti, P, Justesen, JM, Kahali, B, Karaleftheri, M, Kardia, SLR, Karpe, F, Kee, F, Kitajima, H, Komulainen, P, Kooner, JS, Kovacs, P, Krämer, BK, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, TA, Lamparter, D, Lange, LA, Langenberg, C, Larson, EB, Lee, NR, Lee, W, Lehtimäki, T, Lewis, CE, Li, H, Li, J, Li-gao, R, Lin, L, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C, Liu, DJ, Luan, J, Lyytikäinen, L, Macgregor, S, Mägi, R, Männistö, S, Marenne, G, Marten, J, Masca, NGD, Mccarthy, MI, Meidtner, K, Mihailov, E, Moilanen, L, Moitry, M, Mook-kanamori, DO, Morgan, A, Morris, AP, Müller-nurasyid, M, Munroe, PB, Narisu, N, Nelson, CP, Neville, M, Ntalla, I, O’connell, JR, Owen, KR, Pedersen, O, Peloso, GM, Pennell, CE, Perola, M, Perry, JA, Perry, JRB, Pers, TH, Ewing, A, Polasek, O, Raitakari, OT, Rasheed, A, Raulerson, CK, Rauramaa, R, Reilly, DF, Reiner, AP, Ridker, PM, Rivas, MA, Robertson, NR, Robino, A, Rudan, I, Ruth, KS, Saleheen, D, Salomaa, V, Samani, NJ, Schreiner, PJ, Schulze, MB, Scott, RA, Segura-lepe, M, Sim, X, Slater, AJ, Small, KS, Smith, BH, Smith, JA, Southam, L, Spector, TD, Speliotes, EK, Stefansson, K, Steinthorsdottir, V, Stirrups, KE, Strauch, K, Stringham, HM, Stumvoll, M, Sun, L, Surendran, P, Swart, KMA, Tardif, J, Taylor, KD, Teumer, A, Thompson, DJ, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, BH, Tönjes, A, Torres, M, Tsafantakis, E, Tuomilehto, J, Uitterlinden, AG, Uusitupa, M, Van Duijn, CM, Vanhala, M, Varma, R, Vermeulen, SH, Vestergaard, H, Vitart, V, Vogt, TF, Vuckovic, D, Wagenknecht, LE, Walker, M, Wallentin, L, Wang, F, Wang, CA, Wang, S, Wareham, NJ, Warren, HR, Waterworth, DM, Wessel, J, White, HD, Willer, CJ, Wilson, JG, Wood, AR, Wu, Y, Yaghootkar, H, Yao, J, Yerges-armstrong, LM, Young, R, Zeggini, E, Zhan, X, Zhang, W, Zhao, JH, Zhao, W, Zheng, H, Zhou, W, Zillikens, MC, Rivadeneira, F, Borecki, IB, Pospisilik, JA, Deloukas, P, Frayling, TM, Lettre, G, Mohlke, KL, Rotter, JI, Kutalik, Z, Hirschhorn, JN, Cupples, LA, Loos, RJF, North, KE & Lindgren, CM 2019, 'Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution', Nature Genetics, vol. 51, no. 3, pp. 452-469. https://doi.org/10.1038/s41588-018-0334-2

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. / Justice, Anne E.; Karaderi, Tugce; Highland, Heather M.; Young, Kristin L.; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L.; Fine, Rebecca S.; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W.; Locke, Adam E.; Medina-gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush; Lo, Ken Sin; Alfred, Tamuno; Mudgal, Poorva; Ng, Maggie C. Y.; Heard-costa, Nancy L.; Feitosa, Mary F.; Manning, Alisa K.; Willems, Sara M.; Sivapalaratnam, Suthesh; Abecasis, Goncalo; Alam, Dewan S.; Allison, Matthew; Amouyel, Philippe; Arzumanyan, Zorayr; Balkau, Beverley; Bastarache, Lisa; Bergmann, Sven; Bielak, Lawrence F.; Blüher, Matthias; Boehnke, Michael; Boeing, Heiner; Boerwinkle, Eric; Böger, Carsten A.; Bork-jensen, Jette; Bottinger, Erwin P.; Bowden, Donald W.; Brandslund, Ivan; Broer, Linda; Burt, Amber A.; Butterworth, Adam S.; Caulfield, Mark J.; Cesana, Giancarlo; Chambers, John C.; Chasman, Daniel I.; Chen, Yii-der Ida; Chowdhury, Rajiv; Christensen, Cramer; Chu, Audrey Y.; Collins, Francis S.; Cook, James P.; Cox, Amanda J.; Crosslin, David S.; Danesh, John; De Bakker, Paul I. W.; Denus, Simon De; Mutsert, Renée De; Dedoussis, George; Demerath, Ellen W.; Dennis, Joe G.; Denny, Josh C.; Di Angelantonio, Emanuele; Dörr, Marcus; Drenos, Fotios; Dubé, Marie-pierre; Dunning, Alison M.; Easton, Douglas F.; Elliott, Paul; Evangelou, Evangelos; Farmaki, Aliki-eleni; Feng, Shuang; Ferrannini, Ele; Ferrieres, Jean; Florez, Jose C.; Fornage, Myriam; Fox, Caroline S.; Franks, Paul W.; Friedrich, Nele; Gan, Wei; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilmantas; Girotto, Giorgia; Gorski, Mathias; Grallert, Harald; Grarup, Niels; Grove, Megan L.; Gustafsson, Stefan; Haessler, Jeff; Hansen, Torben; Hattersley, Andrew T.; Hayward, Caroline; Heid, Iris M.; Holmen, Oddgeir L.; Hovingh, G. Kees; Howson, Joanna M. M.; Hu, Yao; Hung, Yi-jen; Hveem, Kristian; Ikram, M. Arfan; Ingelsson, Erik; Jackson, Anne U.; Jarvik, Gail P.; Jia, Yucheng; Jørgensen, Torben; Jousilahti, Pekka; Justesen, Johanne M.; Kahali, Bratati; Karaleftheri, Maria; Kardia, Sharon L. R.; Karpe, Fredrik; Kee, Frank; Kitajima, Hidetoshi; Komulainen, Pirjo; Kooner, Jaspal S.; Kovacs, Peter; Krämer, Bernhard K.; Kuulasmaa, Kari; Kuusisto, Johanna; Laakso, Markku; Lakka, Timo A.; Lamparter, David; Lange, Leslie A.; Langenberg, Claudia; Larson, Eric B.; Lee, Nanette R.; Lee, Wen-jane; Lehtimäki, Terho; Lewis, Cora E.; Li, Huaixing; Li, Jin; Li-gao, Ruifang; Lin, Li-an; Lin, Xu; Lind, Lars; Lindström, Jaana; Linneberg, Allan; Liu, Ching-ti; Liu, Dajiang J.; Luan, Jian’an; Lyytikäinen, Leo-pekka; Macgregor, Stuart; Mägi, Reedik; Männistö, Satu; Marenne, Gaëlle; Marten, Jonathan; Masca, Nicholas G. D.; Mccarthy, Mark I.; Meidtner, Karina; Mihailov, Evelin; Moilanen, Leena; Moitry, Marie; Mook-kanamori, Dennis O.; Morgan, Anna; Morris, Andrew P.; Müller-nurasyid, Martina; Munroe, Patricia B.; Narisu, Narisu; Nelson, Christopher P.; Neville, Matt; Ntalla, Ioanna; O’connell, Jeffrey R.; Owen, Katharine R.; Pedersen, Oluf; Peloso, Gina M.; Pennell, Craig E.; Perola, Markus; Perry, James A.; Perry, John R. B.; Pers, Tune H.; Ewing, Ailith; Polasek, Ozren; Raitakari, Olli T.; Rasheed, Asif; Raulerson, Chelsea K.; Rauramaa, Rainer; Reilly, Dermot F.; Reiner, Alex P.; Ridker, Paul M.; Rivas, Manuel A.; Robertson, Neil R.; Robino, Antonietta; Rudan, Igor; Ruth, Katherine S.; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J.; Schreiner, Pamela J.; Schulze, Matthias B.; Scott, Robert A.; Segura-lepe, Marcelo; Sim, Xueling; Slater, Andrew J.; Small, Kerrin S.; Smith, Blair H.; Smith, Jennifer A.; Southam, Lorraine; Spector, Timothy D.; Speliotes, Elizabeth K.; Stefansson, Kari; Steinthorsdottir, Valgerdur; Stirrups, Kathleen E.; Strauch, Konstantin; Stringham, Heather M.; Stumvoll, Michael; Sun, Liang; Surendran, Praveen; Swart, Karin M. A.; Tardif, Jean-claude; Taylor, Kent D.; Teumer, Alexander; Thompson, Deborah J.; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Thuesen, Betina H.; Tönjes, Anke; Torres, Mina; Tsafantakis, Emmanouil; Tuomilehto, Jaakko; Uitterlinden, André G.; Uusitupa, Matti; Van Duijn, Cornelia M.; Vanhala, Mauno; Varma, Rohit; Vermeulen, Sita H.; Vestergaard, Henrik; Vitart, Veronique; Vogt, Thomas F.; Vuckovic, Dragana; Wagenknecht, Lynne E.; Walker, Mark; Wallentin, Lars; Wang, Feijie; Wang, Carol A.; Wang, Shuai; Wareham, Nicholas J.; Warren, Helen R.; Waterworth, Dawn M.; Wessel, Jennifer; White, Harvey D.; Willer, Cristen J.; Wilson, James G.; Wood, Andrew R.; Wu, Ying; Yaghootkar, Hanieh; Yao, Jie; Yerges-armstrong, Laura M.; Young, Robin; Zeggini, Eleftheria; Zhan, Xiaowei; Zhang, Weihua; Zhao, Jing Hua; Zhao, Wei; Zheng, He; Zhou, Wei; Zillikens, M. Carola; Rivadeneira, Fernando; Borecki, Ingrid B.; Pospisilik, J. Andrew; Deloukas, Panos; Frayling, Timothy M.; Lettre, Guillaume; Mohlke, Karen L.; Rotter, Jerome I.; Kutalik, Zoltán; Hirschhorn, Joel N.; Cupples, L. Adrienne; Loos, Ruth J. F.; North, Kari E.; Lindgren, Cecilia M.

In: Nature Genetics, Vol. 51, No. 3, 2019, p. 452-469.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

AU - Justice, Anne E.

AU - Karaderi, Tugce

AU - Highland, Heather M.

AU - Young, Kristin L.

AU - Graff, Mariaelisa

AU - Lu, Yingchang

AU - Turcot, Valérie

AU - Auer, Paul L.

AU - Fine, Rebecca S.

AU - Guo, Xiuqing

AU - Schurmann, Claudia

AU - Lempradl, Adelheid

AU - Marouli, Eirini

AU - Mahajan, Anubha

AU - Winkler, Thomas W.

AU - Locke, Adam E.

AU - Medina-gomez, Carolina

AU - Esko, Tõnu

AU - Vedantam, Sailaja

AU - Giri, Ayush

AU - Lo, Ken Sin

AU - Alfred, Tamuno

AU - Mudgal, Poorva

AU - Ng, Maggie C. Y.

AU - Heard-costa, Nancy L.

AU - Feitosa, Mary F.

AU - Manning, Alisa K.

AU - Willems, Sara M.

AU - Sivapalaratnam, Suthesh

AU - Abecasis, Goncalo

AU - Alam, Dewan S.

AU - Allison, Matthew

AU - Amouyel, Philippe

AU - Arzumanyan, Zorayr

AU - Balkau, Beverley

AU - Bastarache, Lisa

AU - Bergmann, Sven

AU - Bielak, Lawrence F.

AU - Blüher, Matthias

AU - Boehnke, Michael

AU - Boeing, Heiner

AU - Boerwinkle, Eric

AU - Böger, Carsten A.

AU - Bork-jensen, Jette

AU - Bottinger, Erwin P.

AU - Bowden, Donald W.

AU - Brandslund, Ivan

AU - Broer, Linda

AU - Burt, Amber A.

AU - Butterworth, Adam S.

AU - Caulfield, Mark J.

AU - Cesana, Giancarlo

AU - Chambers, John C.

AU - Chasman, Daniel I.

AU - Chen, Yii-der Ida

AU - Chowdhury, Rajiv

AU - Christensen, Cramer

AU - Chu, Audrey Y.

AU - Collins, Francis S.

AU - Cook, James P.

AU - Cox, Amanda J.

AU - Crosslin, David S.

AU - Danesh, John

AU - De Bakker, Paul I. W.

AU - Denus, Simon De

AU - Mutsert, Renée De

AU - Dedoussis, George

AU - Demerath, Ellen W.

AU - Dennis, Joe G.

AU - Denny, Josh C.

AU - Di Angelantonio, Emanuele

AU - Dörr, Marcus

AU - Drenos, Fotios

AU - Dubé, Marie-pierre

AU - Dunning, Alison M.

AU - Easton, Douglas F.

AU - Elliott, Paul

AU - Evangelou, Evangelos

AU - Farmaki, Aliki-eleni

AU - Feng, Shuang

AU - Ferrannini, Ele

AU - Ferrieres, Jean

AU - Florez, Jose C.

AU - Fornage, Myriam

AU - Fox, Caroline S.

AU - Franks, Paul W.

AU - Friedrich, Nele

AU - Gan, Wei

AU - Gandin, Ilaria

AU - Gasparini, Paolo

AU - Giedraitis, Vilmantas

AU - Girotto, Giorgia

AU - Gorski, Mathias

AU - Grallert, Harald

AU - Grarup, Niels

AU - Grove, Megan L.

AU - Gustafsson, Stefan

AU - Haessler, Jeff

AU - Hansen, Torben

AU - Hattersley, Andrew T.

AU - Hayward, Caroline

AU - Heid, Iris M.

AU - Holmen, Oddgeir L.

AU - Hovingh, G. Kees

AU - Howson, Joanna M. M.

AU - Hu, Yao

AU - Hung, Yi-jen

AU - Hveem, Kristian

AU - Ikram, M. Arfan

AU - Ingelsson, Erik

AU - Jackson, Anne U.

AU - Jarvik, Gail P.

AU - Jia, Yucheng

AU - Jørgensen, Torben

AU - Jousilahti, Pekka

AU - Justesen, Johanne M.

AU - Kahali, Bratati

AU - Karaleftheri, Maria

AU - Kardia, Sharon L. R.

AU - Karpe, Fredrik

AU - Kee, Frank

AU - Kitajima, Hidetoshi

AU - Komulainen, Pirjo

AU - Kooner, Jaspal S.

AU - Kovacs, Peter

AU - Krämer, Bernhard K.

AU - Kuulasmaa, Kari

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lakka, Timo A.

AU - Lamparter, David

AU - Lange, Leslie A.

AU - Langenberg, Claudia

AU - Larson, Eric B.

AU - Lee, Nanette R.

AU - Lee, Wen-jane

AU - Lehtimäki, Terho

AU - Lewis, Cora E.

AU - Li, Huaixing

AU - Li, Jin

AU - Li-gao, Ruifang

AU - Lin, Li-an

AU - Lin, Xu

AU - Lind, Lars

AU - Lindström, Jaana

AU - Linneberg, Allan

AU - Liu, Ching-ti

AU - Liu, Dajiang J.

AU - Luan, Jian’an

AU - Lyytikäinen, Leo-pekka

AU - Macgregor, Stuart

AU - Mägi, Reedik

AU - Männistö, Satu

AU - Marenne, Gaëlle

AU - Marten, Jonathan

AU - Masca, Nicholas G. D.

AU - Mccarthy, Mark I.

AU - Meidtner, Karina

AU - Mihailov, Evelin

AU - Moilanen, Leena

AU - Moitry, Marie

AU - Mook-kanamori, Dennis O.

AU - Morgan, Anna

AU - Morris, Andrew P.

AU - Müller-nurasyid, Martina

AU - Munroe, Patricia B.

AU - Narisu, Narisu

AU - Nelson, Christopher P.

AU - Neville, Matt

AU - Ntalla, Ioanna

AU - O’connell, Jeffrey R.

AU - Owen, Katharine R.

AU - Pedersen, Oluf

AU - Peloso, Gina M.

AU - Pennell, Craig E.

AU - Perola, Markus

AU - Perry, James A.

AU - Perry, John R. B.

AU - Pers, Tune H.

AU - Ewing, Ailith

AU - Polasek, Ozren

AU - Raitakari, Olli T.

AU - Rasheed, Asif

AU - Raulerson, Chelsea K.

AU - Rauramaa, Rainer

AU - Reilly, Dermot F.

AU - Reiner, Alex P.

AU - Ridker, Paul M.

AU - Rivas, Manuel A.

AU - Robertson, Neil R.

AU - Robino, Antonietta

AU - Rudan, Igor

AU - Ruth, Katherine S.

AU - Saleheen, Danish

AU - Salomaa, Veikko

AU - Samani, Nilesh J.

AU - Schreiner, Pamela J.

AU - Schulze, Matthias B.

AU - Scott, Robert A.

AU - Segura-lepe, Marcelo

AU - Sim, Xueling

AU - Slater, Andrew J.

AU - Small, Kerrin S.

AU - Smith, Blair H.

AU - Smith, Jennifer A.

AU - Southam, Lorraine

AU - Spector, Timothy D.

AU - Speliotes, Elizabeth K.

AU - Stefansson, Kari

AU - Steinthorsdottir, Valgerdur

AU - Stirrups, Kathleen E.

AU - Strauch, Konstantin

AU - Stringham, Heather M.

AU - Stumvoll, Michael

AU - Sun, Liang

AU - Surendran, Praveen

AU - Swart, Karin M. A.

AU - Tardif, Jean-claude

AU - Taylor, Kent D.

AU - Teumer, Alexander

AU - Thompson, Deborah J.

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Thuesen, Betina H.

AU - Tönjes, Anke

AU - Torres, Mina

AU - Tsafantakis, Emmanouil

AU - Tuomilehto, Jaakko

AU - Uitterlinden, André G.

AU - Uusitupa, Matti

AU - Van Duijn, Cornelia M.

AU - Vanhala, Mauno

AU - Varma, Rohit

AU - Vermeulen, Sita H.

AU - Vestergaard, Henrik

AU - Vitart, Veronique

AU - Vogt, Thomas F.

AU - Vuckovic, Dragana

AU - Wagenknecht, Lynne E.

AU - Walker, Mark

AU - Wallentin, Lars

AU - Wang, Feijie

AU - Wang, Carol A.

AU - Wang, Shuai

AU - Wareham, Nicholas J.

AU - Warren, Helen R.

AU - Waterworth, Dawn M.

AU - Wessel, Jennifer

AU - White, Harvey D.

AU - Willer, Cristen J.

AU - Wilson, James G.

AU - Wood, Andrew R.

AU - Wu, Ying

AU - Yaghootkar, Hanieh

AU - Yao, Jie

AU - Yerges-armstrong, Laura M.

AU - Young, Robin

AU - Zeggini, Eleftheria

AU - Zhan, Xiaowei

AU - Zhang, Weihua

AU - Zhao, Jing Hua

AU - Zhao, Wei

AU - Zheng, He

AU - Zhou, Wei

AU - Zillikens, M. Carola

AU - Rivadeneira, Fernando

AU - Borecki, Ingrid B.

AU - Pospisilik, J. Andrew

AU - Deloukas, Panos

AU - Frayling, Timothy M.

AU - Lettre, Guillaume

AU - Mohlke, Karen L.

AU - Rotter, Jerome I.

AU - Kutalik, Zoltán

AU - Hirschhorn, Joel N.

AU - Cupples, L. Adrienne

AU - Loos, Ruth J. F.

AU - North, Kari E.

AU - Lindgren, Cecilia M.

PY - 2019

Y1 - 2019

N2 - Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF

AB - Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF

KW - Animals

KW - Body Fat Distribution/methods

KW - Body Mass Index

KW - Case-Control Studies

KW - Drosophila/genetics

KW - Exome/genetics

KW - Female

KW - Gene Frequency/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Variation/genetics

KW - Genome-Wide Association Study/methods

KW - Homeostasis/genetics

KW - Humans

KW - Lipids/genetics

KW - Male

KW - Proteins/genetics

KW - Risk Factors

KW - Waist-Hip Ratio/methods

KW - ABDOMINAL ADIPOSITY

KW - KINASE 7

KW - RS11209026 POLYMORPHISM

KW - INSULIN-RESISTANCE

KW - ADIPOCYTE DIFFERENTIATION

KW - ADIPOSE-TISSUE

KW - GENOME-WIDE ASSOCIATION

KW - TYPE-2 DIABETES SUSCEPTIBILITY

KW - WAIST CIRCUMFERENCE

KW - RECEPTOR ALK7

U2 - 10.1038/s41588-018-0334-2

DO - 10.1038/s41588-018-0334-2

M3 - Article

VL - 51

SP - 452

EP - 469

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -