Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population

A study from the population-based PROFILES registry

M. van der Poel, S. Oerlemans, H.C. Schouten, F. Mols, J.F.M. Pruijt, H. Maas, L.V. van de Poll-Franse

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The objective of this study was to compare health-related quality of life (HRQOL) between diffuse large B cell lymphoma (DLBCL) survivors of different age categories (18–59/60–75/76–85 years) and to compare their HRQOL with an age- and sex-matched normative population. The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with DLBCL from 1999 to 2010. Patients (n = 363) were invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questionnaire, and 307 survivors responded (85 %). Data from an age- and sex-matched normative population (n = 596) were used for comparison. DLBCL survivors aged 18–59 years scored better on physical functioning, quality of life, appetite loss and constipation than survivors of 76–85 years old (all p < 0.05). Financial problems more often occurred in survivors aged 18–59 years compared to survivors of 76–85 years old (p < 0.01). Compared to the normative population, DLBCL survivors aged 18–59 years showed worse scores on cognitive and social functioning and on dyspnea and financial problems (p < 0.01, large- and medium-size effects). In survivors of the other age categories, only differences with trivial or small-size effects were found. Although younger DLBCL survivors have better HRQOL than older survivors, the differences found between younger survivors and normative population were the largest. This suggests that having DLBCL has a greater impact on younger than older survivors and that the worse HRQOL observed in older DLBCL survivors in comparison with younger survivors is caused mostly by age itself and not by the disease. Keywords: Diffuse large B cell lymphoma, Quality of life, Elderly, Population based
Original languageEnglish
Pages (from-to)811-819
JournalAnnals of Hematology
Volume93
Issue number5
DOIs
Publication statusPublished - 2014

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Lymphoma, Large B-Cell, Diffuse
Survivors
Constipation
Neoplasms

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@article{1853b8c1bffa403d9899c76cacbeed91,
title = "Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population: A study from the population-based PROFILES registry",
abstract = "The objective of this study was to compare health-related quality of life (HRQOL) between diffuse large B cell lymphoma (DLBCL) survivors of different age categories (18–59/60–75/76–85 years) and to compare their HRQOL with an age- and sex-matched normative population. The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with DLBCL from 1999 to 2010. Patients (n = 363) were invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questionnaire, and 307 survivors responded (85 {\%}). Data from an age- and sex-matched normative population (n = 596) were used for comparison. DLBCL survivors aged 18–59 years scored better on physical functioning, quality of life, appetite loss and constipation than survivors of 76–85 years old (all p < 0.05). Financial problems more often occurred in survivors aged 18–59 years compared to survivors of 76–85 years old (p < 0.01). Compared to the normative population, DLBCL survivors aged 18–59 years showed worse scores on cognitive and social functioning and on dyspnea and financial problems (p < 0.01, large- and medium-size effects). In survivors of the other age categories, only differences with trivial or small-size effects were found. Although younger DLBCL survivors have better HRQOL than older survivors, the differences found between younger survivors and normative population were the largest. This suggests that having DLBCL has a greater impact on younger than older survivors and that the worse HRQOL observed in older DLBCL survivors in comparison with younger survivors is caused mostly by age itself and not by the disease. Keywords: Diffuse large B cell lymphoma, Quality of life, Elderly, Population based",
author = "{van der Poel}, M. and S. Oerlemans and H.C. Schouten and F. Mols and J.F.M. Pruijt and H. Maas and {van de Poll-Franse}, L.V.",
year = "2014",
doi = "10.1007/s00277-013-1980-1",
language = "English",
volume = "93",
pages = "811--819",
journal = "Annals of Hematology",
issn = "0939-5555",
publisher = "Springer Verlag",
number = "5",

}

Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population : A study from the population-based PROFILES registry. / van der Poel, M.; Oerlemans, S.; Schouten, H.C.; Mols, F.; Pruijt, J.F.M.; Maas, H.; van de Poll-Franse, L.V.

In: Annals of Hematology, Vol. 93, No. 5, 2014, p. 811-819.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population

T2 - A study from the population-based PROFILES registry

AU - van der Poel, M.

AU - Oerlemans, S.

AU - Schouten, H.C.

AU - Mols, F.

AU - Pruijt, J.F.M.

AU - Maas, H.

AU - van de Poll-Franse, L.V.

PY - 2014

Y1 - 2014

N2 - The objective of this study was to compare health-related quality of life (HRQOL) between diffuse large B cell lymphoma (DLBCL) survivors of different age categories (18–59/60–75/76–85 years) and to compare their HRQOL with an age- and sex-matched normative population. The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with DLBCL from 1999 to 2010. Patients (n = 363) were invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questionnaire, and 307 survivors responded (85 %). Data from an age- and sex-matched normative population (n = 596) were used for comparison. DLBCL survivors aged 18–59 years scored better on physical functioning, quality of life, appetite loss and constipation than survivors of 76–85 years old (all p < 0.05). Financial problems more often occurred in survivors aged 18–59 years compared to survivors of 76–85 years old (p < 0.01). Compared to the normative population, DLBCL survivors aged 18–59 years showed worse scores on cognitive and social functioning and on dyspnea and financial problems (p < 0.01, large- and medium-size effects). In survivors of the other age categories, only differences with trivial or small-size effects were found. Although younger DLBCL survivors have better HRQOL than older survivors, the differences found between younger survivors and normative population were the largest. This suggests that having DLBCL has a greater impact on younger than older survivors and that the worse HRQOL observed in older DLBCL survivors in comparison with younger survivors is caused mostly by age itself and not by the disease. Keywords: Diffuse large B cell lymphoma, Quality of life, Elderly, Population based

AB - The objective of this study was to compare health-related quality of life (HRQOL) between diffuse large B cell lymphoma (DLBCL) survivors of different age categories (18–59/60–75/76–85 years) and to compare their HRQOL with an age- and sex-matched normative population. The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with DLBCL from 1999 to 2010. Patients (n = 363) were invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questionnaire, and 307 survivors responded (85 %). Data from an age- and sex-matched normative population (n = 596) were used for comparison. DLBCL survivors aged 18–59 years scored better on physical functioning, quality of life, appetite loss and constipation than survivors of 76–85 years old (all p < 0.05). Financial problems more often occurred in survivors aged 18–59 years compared to survivors of 76–85 years old (p < 0.01). Compared to the normative population, DLBCL survivors aged 18–59 years showed worse scores on cognitive and social functioning and on dyspnea and financial problems (p < 0.01, large- and medium-size effects). In survivors of the other age categories, only differences with trivial or small-size effects were found. Although younger DLBCL survivors have better HRQOL than older survivors, the differences found between younger survivors and normative population were the largest. This suggests that having DLBCL has a greater impact on younger than older survivors and that the worse HRQOL observed in older DLBCL survivors in comparison with younger survivors is caused mostly by age itself and not by the disease. Keywords: Diffuse large B cell lymphoma, Quality of life, Elderly, Population based

UR - http://hdl.handle.net/10411/20455

U2 - 10.1007/s00277-013-1980-1

DO - 10.1007/s00277-013-1980-1

M3 - Article

VL - 93

SP - 811

EP - 819

JO - Annals of Hematology

JF - Annals of Hematology

SN - 0939-5555

IS - 5

ER -