Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls

European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG); Sofia Chantziara; Jammbe Musoro; Alison C Rowsell; Charlotte Sleurs; Corneel Coens; Madeline Pe; Stefan Suciu; Michal Kicinski; Pierre Missotten; Els Vandecruys; Anne Uyttebroeck; Marie-Françoise Dresse; Claire Pluchart; Alina Ferster; Claire Freycon; Jutte Van Der Werff Ten Bosch; Pierre Rohrlich; Yves Benoit; Anne-Sophie Darlington; Caroline Piette

doi:10.1002/pon.6060

Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls

European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG), Sofia Chantziara, Jammbe Musoro, Alison C Rowsell, Charlotte Sleurs, Corneel Coens, Madeline Pe, Stefan Suciu, Michal Kicinski, Pierre Missotten, Els Vandecruys, Anne Uyttebroeck, Marie-Françoise Dresse, Claire Pluchart, Alina Ferster, Claire Freycon, Jutte Van Der Werff Ten Bosch, Pierre Rohrlich, Yves Benoit, Anne-Sophie Darlington^*Caroline Piette

^*Corresponding author for this work

Cognitive Neuropsychology

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

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Abstract

Objective:

Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.

Methods:

QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.

Results:

One hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1-52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.

Conclusions:

Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.

Original language	English
Pages (from-to)	2159-2168
Journal	Psycho-Oncology
Volume	31
Issue number	12
DOIs	https://doi.org/10.1002/pon.6060
Publication status	Published - 2022

Keywords

ADOLESCENT
CANCER
CHILDREN
EXPERIENCES
FATIGUE
OUTCOMES
SELF-PERCEPTIONS
TRIALS
YOUNG-ADULT SURVIVORS
acute lymphoblastic
adolescent
cancer survivors
child
leukemia
quality of life
survivorship
young adult

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CNP Sleurs quality of life of long‐term childhood acute lymphoblastic leukemia survivors PO 2022Final published version, 425 KBLicence: CC BY

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European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG), Chantziara, S., Musoro, J., Rowsell, A. C., Sleurs, C., Coens, C., Pe, M., Suciu, S., Kicinski, M., Missotten, P., Vandecruys, E., Uyttebroeck, A., Dresse, M.-F., Pluchart, C., Ferster, A., Freycon, C., Bosch, J. V. D. W. T., Rohrlich, P., Benoit, Y., ... Piette, C. (2022). Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls. Psycho-Oncology, 31(12), 2159-2168. https://doi.org/10.1002/pon.6060

@article{91c10a2ed14f46ff929c2851fa44a090,

title = "Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls",

abstract = "Objective: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.Methods: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.Results: One hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1-52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.Conclusions: Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.",

keywords = "ADOLESCENT, CANCER, CHILDREN, EXPERIENCES, FATIGUE, OUTCOMES, SELF-PERCEPTIONS, TRIALS, YOUNG-ADULT SURVIVORS, acute lymphoblastic, adolescent, cancer survivors, child, leukemia, quality of life, survivorship, young adult",

author = "{European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG)} and Sofia Chantziara and Jammbe Musoro and Rowsell, {Alison C} and Charlotte Sleurs and Corneel Coens and Madeline Pe and Stefan Suciu and Michal Kicinski and Pierre Missotten and Els Vandecruys and Anne Uyttebroeck and Marie-Fran{\c c}oise Dresse and Claire Pluchart and Alina Ferster and Claire Freycon and Bosch, {Jutte Van Der Werff Ten} and Pierre Rohrlich and Yves Benoit and Anne-Sophie Darlington and Caroline Piette",

note = "Funding Information: This work was supported by the EORTC Quality of Life Group grant 013/2016, Fonds Cancer (FOCA) from Belgium and the Kinderkankerfonds from Belgium (a non-profit childhood cancer foundation under Belgian law) and Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society from Belgium. ",

year = "2022",

doi = "10.1002/pon.6060",

language = "English",

volume = "31",

pages = "2159--2168",

journal = "Psycho-Oncology",

issn = "1057-9249",

publisher = "John Wiley and Sons Ltd",

number = "12",

}

European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG), Chantziara, S, Musoro, J, Rowsell, AC, Sleurs, C, Coens, C, Pe, M, Suciu, S, Kicinski, M, Missotten, P, Vandecruys, E, Uyttebroeck, A, Dresse, M-F, Pluchart, C, Ferster, A, Freycon, C, Bosch, JVDWT, Rohrlich, P, Benoit, Y, Darlington, A-S & Piette, C 2022, 'Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls', Psycho-Oncology, vol. 31, no. 12, pp. 2159-2168. https://doi.org/10.1002/pon.6060

Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls. / European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG); Chantziara, Sofia; Musoro, Jammbe et al.
In: Psycho-Oncology, Vol. 31, No. 12, 2022, p. 2159-2168.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Quality of life of long-term childhood acute lymphoblastic leukemia survivors

T2 - Comparison with healthy controls

AU - European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG)

AU - Chantziara, Sofia

AU - Musoro, Jammbe

AU - Rowsell, Alison C

AU - Sleurs, Charlotte

AU - Coens, Corneel

AU - Pe, Madeline

AU - Suciu, Stefan

AU - Kicinski, Michal

AU - Missotten, Pierre

AU - Vandecruys, Els

AU - Uyttebroeck, Anne

AU - Dresse, Marie-Françoise

AU - Pluchart, Claire

AU - Ferster, Alina

AU - Freycon, Claire

AU - Bosch, Jutte Van Der Werff Ten

AU - Rohrlich, Pierre

AU - Benoit, Yves

AU - Darlington, Anne-Sophie

AU - Piette, Caroline

N1 - Funding Information: This work was supported by the EORTC Quality of Life Group grant 013/2016, Fonds Cancer (FOCA) from Belgium and the Kinderkankerfonds from Belgium (a non-profit childhood cancer foundation under Belgian law) and Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society from Belgium.

PY - 2022

Y1 - 2022

N2 - Objective: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.Methods: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.Results: One hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1-52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.Conclusions: Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.

AB - Objective: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.Methods: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.Results: One hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1-52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.Conclusions: Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.

KW - ADOLESCENT

KW - CANCER

KW - CHILDREN

KW - EXPERIENCES

KW - FATIGUE

KW - OUTCOMES

KW - SELF-PERCEPTIONS

KW - TRIALS

KW - YOUNG-ADULT SURVIVORS

KW - acute lymphoblastic

KW - adolescent

KW - cancer survivors

KW - child

KW - leukemia

KW - quality of life

KW - survivorship

KW - young adult

UR - http://www.scopus.com/inward/record.url?scp=85143285087&partnerID=8YFLogxK

U2 - 10.1002/pon.6060

DO - 10.1002/pon.6060

M3 - Article

C2 - 36307941

SN - 1057-9249

VL - 31

SP - 2159

EP - 2168

JO - Psycho-Oncology

JF - Psycho-Oncology

IS - 12

ER -

Quality of life of long-term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls

Abstract

Keywords

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