TY - JOUR
T1 - Rationale and design of a randomized trial on the effectiveness of aerobic interval training in patients with coronary artery disease
T2 - The SAINTEX-CAD study
AU - Conraads, Viviane M
AU - Van Craenenbroeck, Emeline M
AU - Pattyn, Nele
AU - Cornelissen, Véronique A
AU - Beckers, Paul J
AU - Coeckelberghs, Ellen
AU - De Maeyer, Catherine
AU - Denollet, J.
AU - Frederix, Geert
AU - Goetschalckx, Kaatje
AU - Hoymans, Vicky Y
AU - Possemiers, Nadine
AU - Schepers, Dirk
AU - Shivalkar, Bharati
AU - Vanhees, Luc
N1 - Copyright © 2013. Published by Elsevier Ireland Ltd.
PY - 2013
Y1 - 2013
N2 - Background: Exercise-based cardiac rehabilitation is considered an important adjunct treatment and secondary prevention measure in patients with coronary artery disease (CAD). However, the issues of training modality and exercise intensity for CAD patients remain controversial.Objective: Main aim of the present study is to test the hypothesis that aerobic interval training (AIT) yields a larger gain in peak aerobic capacity (peakVO2) compared to a similar training programme of moderate continuous training (MCT) in CAD patients.Study design: In this multicentre study stable CAD patients with left ventricular ejection fraction>40% will be randomized after recent myocardial infarction or revascularization (PCI or CABG) to a supervised 12-week programme of three weekly sessions of either AIT (85-90% of peak oxygen uptake [peakVO2], 90-95% of peak heart rate) or MCT (60-70% of peakVO2, 65-75% of peak heart rate). The primary endpoint of the study is the change of peakVO2 after 12 weeks training. Secondary endpoints include safety, changes in peripheral endothelial vascular function, the evolution of traditional cardiovascular risk factors, quality of life and the number and function of circulating endothelial progenitor cells as well as endothelial microparticles. Possible differences in terms of long-term adherence to prescribed exercise regimens will be assessed by regular physical activity questionnaires, accelerometry and reassessment of peakVO2 12 months after randomization. A total number of 200 patients will be randomized in a 1:1 manner (significance level of 0.05 and statistical power of 0.90). Enrolment started December 2010; last enrolment is expected for February 2013.Keywords:Exercise intensity, Exercise training, Coronary artery disease, Secondary prevention, Cardiac rehabilitation
AB - Background: Exercise-based cardiac rehabilitation is considered an important adjunct treatment and secondary prevention measure in patients with coronary artery disease (CAD). However, the issues of training modality and exercise intensity for CAD patients remain controversial.Objective: Main aim of the present study is to test the hypothesis that aerobic interval training (AIT) yields a larger gain in peak aerobic capacity (peakVO2) compared to a similar training programme of moderate continuous training (MCT) in CAD patients.Study design: In this multicentre study stable CAD patients with left ventricular ejection fraction>40% will be randomized after recent myocardial infarction or revascularization (PCI or CABG) to a supervised 12-week programme of three weekly sessions of either AIT (85-90% of peak oxygen uptake [peakVO2], 90-95% of peak heart rate) or MCT (60-70% of peakVO2, 65-75% of peak heart rate). The primary endpoint of the study is the change of peakVO2 after 12 weeks training. Secondary endpoints include safety, changes in peripheral endothelial vascular function, the evolution of traditional cardiovascular risk factors, quality of life and the number and function of circulating endothelial progenitor cells as well as endothelial microparticles. Possible differences in terms of long-term adherence to prescribed exercise regimens will be assessed by regular physical activity questionnaires, accelerometry and reassessment of peakVO2 12 months after randomization. A total number of 200 patients will be randomized in a 1:1 manner (significance level of 0.05 and statistical power of 0.90). Enrolment started December 2010; last enrolment is expected for February 2013.Keywords:Exercise intensity, Exercise training, Coronary artery disease, Secondary prevention, Cardiac rehabilitation
KW - Coronary Artery Disease
KW - Exercise
KW - Exercise Tolerance
KW - Follow-Up Studies
KW - Humans
KW - Longitudinal Studies
KW - Prospective Studies
KW - Secondary Prevention
KW - Stroke Volume
KW - Treatment Outcome
U2 - 10.1016/j.ijcard.2013.05.007
DO - 10.1016/j.ijcard.2013.05.007
M3 - Article
C2 - 23711446
SN - 0167-5273
VL - 168
SP - 3532
EP - 3536
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 4
ER -