Rationale and design of a randomized trial on the effectiveness of aerobic interval training in patients with coronary artery disease: The SAINTEX-CAD study

Viviane M Conraads, Emeline M Van Craenenbroeck, Nele Pattyn, Véronique A Cornelissen, Paul J Beckers, Ellen Coeckelberghs, Catherine De Maeyer, J. Denollet, Geert Frederix, Kaatje Goetschalckx, Vicky Y Hoymans, Nadine Possemiers, Dirk Schepers, Bharati Shivalkar, Luc Vanhees

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Abstract

Background:

Exercise-based cardiac rehabilitation is considered an important adjunct treatment and secondary prevention measure in patients with coronary artery disease (CAD). However, the issues of training modality and exercise intensity for CAD patients remain controversial.

Objective:

Main aim of the present study is to test the hypothesis that aerobic interval training (AIT) yields a larger gain in peak aerobic capacity (peakVO2) compared to a similar training programme of moderate continuous training (MCT) in CAD patients.

Study design:

In this multicentre study stable CAD patients with left ventricular ejection fraction>40% will be randomized after recent myocardial infarction or revascularization (PCI or CABG) to a supervised 12-week programme of three weekly sessions of either AIT (85-90% of peak oxygen uptake [peakVO2], 90-95% of peak heart rate) or MCT (60-70% of peakVO2, 65-75% of peak heart rate). The primary endpoint of the study is the change of peakVO2 after 12 weeks training. Secondary endpoints include safety, changes in peripheral endothelial vascular function, the evolution of traditional cardiovascular risk factors, quality of life and the number and function of circulating endothelial progenitor cells as well as endothelial microparticles. Possible differences in terms of long-term adherence to prescribed exercise regimens will be assessed by regular physical activity questionnaires, accelerometry and reassessment of peakVO2 12 months after randomization. A total number of 200 patients will be randomized in a 1:1 manner (significance level of 0.05 and statistical power of 0.90). Enrolment started December 2010; last enrolment is expected for February 2013.

Keywords:Exercise intensity, Exercise training, Coronary artery disease, Secondary prevention, Cardiac rehabilitation

Original languageEnglish
Pages (from-to)3532-3536
JournalInternational Journal of Cardiology
Volume168
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • Coronary Artery Disease
  • Exercise
  • Exercise Tolerance
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Prospective Studies
  • Secondary Prevention
  • Stroke Volume
  • Treatment Outcome

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    Conraads, V. M., Van Craenenbroeck, E. M., Pattyn, N., Cornelissen, V. A., Beckers, P. J., Coeckelberghs, E., De Maeyer, C., Denollet, J., Frederix, G., Goetschalckx, K., Hoymans, V. Y., Possemiers, N., Schepers, D., Shivalkar, B., & Vanhees, L. (2013). Rationale and design of a randomized trial on the effectiveness of aerobic interval training in patients with coronary artery disease: The SAINTEX-CAD study. International Journal of Cardiology, 168(4), 3532-3536. https://doi.org/10.1016/j.ijcard.2013.05.007