Reduced positive affect (anhedonia) is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention

Results from the RESEARCH registry

N.L.M. Damen, A.J.M. Pelle, E. Boersma, P.W. Serruys, R.T. van Domburg, S.S. Pedersen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Aims:
Negative mood states (e.g., anxiety and depression) have been associated with increased cardiovascular morbidity and mortality in coronary artery disease (CAD), but little is known about the impact of positive emotions on these health outcomes. We examined whether anhedonia (i.e., reduced positive affect) was associated with 7-year mortality in patients treated with percutaneous coronary intervention (PCI)
Methods:
Consecutive PCI patients (n = 1206; 71.5% men; mean age 62.0 ± 11.1 years) from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed the Hospital Anxiety and Depression Scale (HADS) to assess anhedonia at baseline. Anhedonia was defined as a score ≤7 (i.e., one SD below the mean) on the positive affect scale of the HADS. The endpoint was defined as all-cause mortality.Results: The prevalence of anhedonia was 23.7% (286/1206). After a median follow up of 7.0 ± 1.6 years, 186 deaths (15.4%) from any cause were recorded. The incidence of mortality in anhedonic patients was 22.7% (65/286) vs. 13.2% (121/920) in non-anhedonic patients (HR = 1.66, 95% CI [1.19–2.32], p = 0.003). Cumulative hazard functions were significantly different for anhedonic vs. non-anhedonic patients (log-rank χ2 = 16.61, p < 0.001). In multivariable analysis, anhedonia remained independently associated with all-cause mortality (HR = 1.51, 95% CI [1.03–2.22], p = 0.036), after adjusting for socio-demographics, clinical characteristics, and negative and relaxed affect.
Conclusion:
Anhedonia was independently associated with a 1.5-fold increased risk for all-cause mortality in patients who survived the first 6 months post-PCI. Enhancing positive emotions, in addition to reducing negative emotions, may constitute an important target for future psychological intervention trials in CAD patients.Keywords: All-cause mortality, anhedonia, coronary artery disease, percutaneous coronary intervention
Original languageEnglish
Pages (from-to)127-134
JournalEuropean Journal of Preventive Cardiology
Volume20
Issue number1
DOIs
Publication statusPublished - 2013

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Anhedonia
Stents
Depression
Incidence

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@article{ada27821455b40d7a3f12c1b42eebf56,
title = "Reduced positive affect (anhedonia) is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: Results from the RESEARCH registry",
abstract = "Aims: Negative mood states (e.g., anxiety and depression) have been associated with increased cardiovascular morbidity and mortality in coronary artery disease (CAD), but little is known about the impact of positive emotions on these health outcomes. We examined whether anhedonia (i.e., reduced positive affect) was associated with 7-year mortality in patients treated with percutaneous coronary intervention (PCI)Methods: Consecutive PCI patients (n = 1206; 71.5{\%} men; mean age 62.0 ± 11.1 years) from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed the Hospital Anxiety and Depression Scale (HADS) to assess anhedonia at baseline. Anhedonia was defined as a score ≤7 (i.e., one SD below the mean) on the positive affect scale of the HADS. The endpoint was defined as all-cause mortality.Results: The prevalence of anhedonia was 23.7{\%} (286/1206). After a median follow up of 7.0 ± 1.6 years, 186 deaths (15.4{\%}) from any cause were recorded. The incidence of mortality in anhedonic patients was 22.7{\%} (65/286) vs. 13.2{\%} (121/920) in non-anhedonic patients (HR = 1.66, 95{\%} CI [1.19–2.32], p = 0.003). Cumulative hazard functions were significantly different for anhedonic vs. non-anhedonic patients (log-rank χ2 = 16.61, p < 0.001). In multivariable analysis, anhedonia remained independently associated with all-cause mortality (HR = 1.51, 95{\%} CI [1.03–2.22], p = 0.036), after adjusting for socio-demographics, clinical characteristics, and negative and relaxed affect.Conclusion: Anhedonia was independently associated with a 1.5-fold increased risk for all-cause mortality in patients who survived the first 6 months post-PCI. Enhancing positive emotions, in addition to reducing negative emotions, may constitute an important target for future psychological intervention trials in CAD patients.Keywords: All-cause mortality, anhedonia, coronary artery disease, percutaneous coronary intervention",
author = "N.L.M. Damen and A.J.M. Pelle and E. Boersma and P.W. Serruys and {van Domburg}, R.T. and S.S. Pedersen",
year = "2013",
doi = "10.1177/2047487312436452",
language = "English",
volume = "20",
pages = "127--134",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "Sage Publications Ltd",
number = "1",

}

Reduced positive affect (anhedonia) is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention : Results from the RESEARCH registry. / Damen, N.L.M.; Pelle, A.J.M.; Boersma, E.; Serruys, P.W.; van Domburg, R.T.; Pedersen, S.S.

In: European Journal of Preventive Cardiology, Vol. 20, No. 1, 2013, p. 127-134.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Reduced positive affect (anhedonia) is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention

T2 - Results from the RESEARCH registry

AU - Damen, N.L.M.

AU - Pelle, A.J.M.

AU - Boersma, E.

AU - Serruys, P.W.

AU - van Domburg, R.T.

AU - Pedersen, S.S.

PY - 2013

Y1 - 2013

N2 - Aims: Negative mood states (e.g., anxiety and depression) have been associated with increased cardiovascular morbidity and mortality in coronary artery disease (CAD), but little is known about the impact of positive emotions on these health outcomes. We examined whether anhedonia (i.e., reduced positive affect) was associated with 7-year mortality in patients treated with percutaneous coronary intervention (PCI)Methods: Consecutive PCI patients (n = 1206; 71.5% men; mean age 62.0 ± 11.1 years) from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed the Hospital Anxiety and Depression Scale (HADS) to assess anhedonia at baseline. Anhedonia was defined as a score ≤7 (i.e., one SD below the mean) on the positive affect scale of the HADS. The endpoint was defined as all-cause mortality.Results: The prevalence of anhedonia was 23.7% (286/1206). After a median follow up of 7.0 ± 1.6 years, 186 deaths (15.4%) from any cause were recorded. The incidence of mortality in anhedonic patients was 22.7% (65/286) vs. 13.2% (121/920) in non-anhedonic patients (HR = 1.66, 95% CI [1.19–2.32], p = 0.003). Cumulative hazard functions were significantly different for anhedonic vs. non-anhedonic patients (log-rank χ2 = 16.61, p < 0.001). In multivariable analysis, anhedonia remained independently associated with all-cause mortality (HR = 1.51, 95% CI [1.03–2.22], p = 0.036), after adjusting for socio-demographics, clinical characteristics, and negative and relaxed affect.Conclusion: Anhedonia was independently associated with a 1.5-fold increased risk for all-cause mortality in patients who survived the first 6 months post-PCI. Enhancing positive emotions, in addition to reducing negative emotions, may constitute an important target for future psychological intervention trials in CAD patients.Keywords: All-cause mortality, anhedonia, coronary artery disease, percutaneous coronary intervention

AB - Aims: Negative mood states (e.g., anxiety and depression) have been associated with increased cardiovascular morbidity and mortality in coronary artery disease (CAD), but little is known about the impact of positive emotions on these health outcomes. We examined whether anhedonia (i.e., reduced positive affect) was associated with 7-year mortality in patients treated with percutaneous coronary intervention (PCI)Methods: Consecutive PCI patients (n = 1206; 71.5% men; mean age 62.0 ± 11.1 years) from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed the Hospital Anxiety and Depression Scale (HADS) to assess anhedonia at baseline. Anhedonia was defined as a score ≤7 (i.e., one SD below the mean) on the positive affect scale of the HADS. The endpoint was defined as all-cause mortality.Results: The prevalence of anhedonia was 23.7% (286/1206). After a median follow up of 7.0 ± 1.6 years, 186 deaths (15.4%) from any cause were recorded. The incidence of mortality in anhedonic patients was 22.7% (65/286) vs. 13.2% (121/920) in non-anhedonic patients (HR = 1.66, 95% CI [1.19–2.32], p = 0.003). Cumulative hazard functions were significantly different for anhedonic vs. non-anhedonic patients (log-rank χ2 = 16.61, p < 0.001). In multivariable analysis, anhedonia remained independently associated with all-cause mortality (HR = 1.51, 95% CI [1.03–2.22], p = 0.036), after adjusting for socio-demographics, clinical characteristics, and negative and relaxed affect.Conclusion: Anhedonia was independently associated with a 1.5-fold increased risk for all-cause mortality in patients who survived the first 6 months post-PCI. Enhancing positive emotions, in addition to reducing negative emotions, may constitute an important target for future psychological intervention trials in CAD patients.Keywords: All-cause mortality, anhedonia, coronary artery disease, percutaneous coronary intervention

U2 - 10.1177/2047487312436452

DO - 10.1177/2047487312436452

M3 - Article

VL - 20

SP - 127

EP - 134

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 1

ER -