Reference data of the EORTC QLQ-C30 questionnaire

Five consecutive annual assessments of approximately 2000 representative dutch men and women

F. Mols, O. Husson, Marije Oudejans, Carla Vlooswijk, N. Horevoorts, L.V. van de Poll-Franse

Research output: Contribution to journalArticleScientificpeer-review

1 Downloads (Pure)

Abstract

Objective.
Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.

Methods.
The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333).

Results.
Regarding sex, at baseline, women scored statistically significant and clinically relevant worse on fatigue, pain and insomnia compared to men. Regarding age groups and sex, HRQoL was lower among the older age groups in men and women. For men, at baseline, significant and clinically relevant age differences were found on physical, role and cognitive functioning, global QOL scale, fatigue, pain and dyspnea. The change over 5 years was larger for older age groups. For women, at baseline, significant and clinically relevant age differences were found on physical functioning, role functioning, nausea/vomiting, pain, dyspnea and insomnia. Those without self-reported morbidities reported a better HRQoL compared to those with morbidities. Among those who completed five assessments, the summary scale scores were stable over time, were higher in men than in women, and higher in younger compared to older age groups.

Conclusions.
Although HRQoL remains relatively stable over time, HRQoL data needs to be interpreted with care as many confounding factors can have an impact on HRQOL. Our data (which is freely available) can aid in the interpretation of QLQ-C30 scores and can help increase our understanding of the influence of age, sex, time and morbid conditions on HRQoL among cancer patients.
Original languageEnglish
Pages (from-to)1381-1391
JournalActa Oncologica
Volume57
Issue number10
DOIs
Publication statusPublished - 2018

Fingerprint

Age Groups
Organizations
Neoplasms
Netherlands
Comorbidity
Surveys and Questionnaires

Keywords

  • AGE
  • CANCER
  • CLINICAL-TRIALS
  • EUROPEAN-ORGANIZATION
  • GENDER
  • HIGHER-ORDER MODELS
  • QUALITY-OF-LIFE
  • REFERENCE-VALUES
  • SAMPLE
  • SWEDISH-POPULATION

Cite this

@article{819ba5f81c00453094612143b0e19d46,
title = "Reference data of the EORTC QLQ-C30 questionnaire: Five consecutive annual assessments of approximately 2000 representative dutch men and women",
abstract = "Objective.Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.Methods. The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333).Results. Regarding sex, at baseline, women scored statistically significant and clinically relevant worse on fatigue, pain and insomnia compared to men. Regarding age groups and sex, HRQoL was lower among the older age groups in men and women. For men, at baseline, significant and clinically relevant age differences were found on physical, role and cognitive functioning, global QOL scale, fatigue, pain and dyspnea. The change over 5 years was larger for older age groups. For women, at baseline, significant and clinically relevant age differences were found on physical functioning, role functioning, nausea/vomiting, pain, dyspnea and insomnia. Those without self-reported morbidities reported a better HRQoL compared to those with morbidities. Among those who completed five assessments, the summary scale scores were stable over time, were higher in men than in women, and higher in younger compared to older age groups.Conclusions.Although HRQoL remains relatively stable over time, HRQoL data needs to be interpreted with care as many confounding factors can have an impact on HRQOL. Our data (which is freely available) can aid in the interpretation of QLQ-C30 scores and can help increase our understanding of the influence of age, sex, time and morbid conditions on HRQoL among cancer patients.",
keywords = "AGE, CANCER, CLINICAL-TRIALS, EUROPEAN-ORGANIZATION, GENDER, HIGHER-ORDER MODELS, QUALITY-OF-LIFE, REFERENCE-VALUES, SAMPLE, SWEDISH-POPULATION",
author = "F. Mols and O. Husson and Marije Oudejans and Carla Vlooswijk and N. Horevoorts and {van de Poll-Franse}, L.V.",
year = "2018",
doi = "10.1080/0284186X.2018.1481293",
language = "English",
volume = "57",
pages = "1381--1391",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "TAYLOR & FRANCIS LTD",
number = "10",

}

Reference data of the EORTC QLQ-C30 questionnaire : Five consecutive annual assessments of approximately 2000 representative dutch men and women. / Mols, F.; Husson, O.; Oudejans, Marije; Vlooswijk, Carla; Horevoorts, N.; van de Poll-Franse, L.V.

In: Acta Oncologica, Vol. 57, No. 10, 2018, p. 1381-1391.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Reference data of the EORTC QLQ-C30 questionnaire

T2 - Five consecutive annual assessments of approximately 2000 representative dutch men and women

AU - Mols, F.

AU - Husson, O.

AU - Oudejans, Marije

AU - Vlooswijk, Carla

AU - Horevoorts, N.

AU - van de Poll-Franse, L.V.

PY - 2018

Y1 - 2018

N2 - Objective.Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.Methods. The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333).Results. Regarding sex, at baseline, women scored statistically significant and clinically relevant worse on fatigue, pain and insomnia compared to men. Regarding age groups and sex, HRQoL was lower among the older age groups in men and women. For men, at baseline, significant and clinically relevant age differences were found on physical, role and cognitive functioning, global QOL scale, fatigue, pain and dyspnea. The change over 5 years was larger for older age groups. For women, at baseline, significant and clinically relevant age differences were found on physical functioning, role functioning, nausea/vomiting, pain, dyspnea and insomnia. Those without self-reported morbidities reported a better HRQoL compared to those with morbidities. Among those who completed five assessments, the summary scale scores were stable over time, were higher in men than in women, and higher in younger compared to older age groups.Conclusions.Although HRQoL remains relatively stable over time, HRQoL data needs to be interpreted with care as many confounding factors can have an impact on HRQOL. Our data (which is freely available) can aid in the interpretation of QLQ-C30 scores and can help increase our understanding of the influence of age, sex, time and morbid conditions on HRQoL among cancer patients.

AB - Objective.Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.Methods. The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333).Results. Regarding sex, at baseline, women scored statistically significant and clinically relevant worse on fatigue, pain and insomnia compared to men. Regarding age groups and sex, HRQoL was lower among the older age groups in men and women. For men, at baseline, significant and clinically relevant age differences were found on physical, role and cognitive functioning, global QOL scale, fatigue, pain and dyspnea. The change over 5 years was larger for older age groups. For women, at baseline, significant and clinically relevant age differences were found on physical functioning, role functioning, nausea/vomiting, pain, dyspnea and insomnia. Those without self-reported morbidities reported a better HRQoL compared to those with morbidities. Among those who completed five assessments, the summary scale scores were stable over time, were higher in men than in women, and higher in younger compared to older age groups.Conclusions.Although HRQoL remains relatively stable over time, HRQoL data needs to be interpreted with care as many confounding factors can have an impact on HRQOL. Our data (which is freely available) can aid in the interpretation of QLQ-C30 scores and can help increase our understanding of the influence of age, sex, time and morbid conditions on HRQoL among cancer patients.

KW - AGE

KW - CANCER

KW - CLINICAL-TRIALS

KW - EUROPEAN-ORGANIZATION

KW - GENDER

KW - HIGHER-ORDER MODELS

KW - QUALITY-OF-LIFE

KW - REFERENCE-VALUES

KW - SAMPLE

KW - SWEDISH-POPULATION

U2 - 10.1080/0284186X.2018.1481293

DO - 10.1080/0284186X.2018.1481293

M3 - Article

VL - 57

SP - 1381

EP - 1391

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 10

ER -