Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis

Tara M. Mackay; Anouk E.j. Latenstein; Mirjam A.g. Sprangers; Lydia G. Van Der Geest; Geert-jan Creemers; Susan Van Dieren; Jan-willem B. De Groot; Bas Groot Koerkamp; Ignace H. De Hingh; Marjolein Y.v. Homs; Evelien J.m. De Jong; I. Quintus Molenaar; Gijs A. Patijn; Lonneke V. van de Poll-Franse; Hjalmar C. Van Santvoort; Judith De Vos-geelen; Johanna W. Wilmink; Casper H. Van Eijck; Marc G. Besselink; Hanneke W.m. Van Laarhoven; _ _

doi:10.6004/jnccn.2020.7579

Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis

Tara M. Mackay, Anouk E.j. Latenstein, Mirjam A.g. Sprangers, Lydia G. Van Der Geest, Geert-jan Creemers, Susan Van Dieren, Jan-willem B. De Groot, Bas Groot Koerkamp, Ignace H. De Hingh, Marjolein Y.v. Homs, Evelien J.m. De Jong, I. Quintus Molenaar, Gijs A. Patijn, Lonneke V. van de Poll-Franse, Hjalmar C. Van Santvoort, Judith De Vos-geelen, Johanna W. Wilmink, Casper H. Van Eijck, Marc G. Besselink, Hanneke W.m. Van Laarhoven_ _

Medical and Clinical Psychology

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Patient-reported outcome measures (PROMs) are used increasingly in clinical practice to assess patients’ quality of life (QoL). Addressing QoL is important for patients with a short life expectancy, such as those with pancreatic and periampullary carcinoma, which has a median overall survival of 4 to 6 months.1 Different types of treatment that may improve survival in patients with pancreatic cancer may also impact QoL. Pancreatic resection has been found to be associated with a temporary deterioration in QoL, which usually returns to baseline values after 3 to 6 months.2,3 Moreover, chemotherapy has been found to improve QoL in randomized studies in the adjuvant and palliative setting.4,5

QoL may also be used to predict survival. Previous studies with other types of cancer (eg, breast, lung, esophageal, liver) consistently found a correlation between QoL and survival.6–11 Previous studies combined patients with different types of cancer, including a limited number (∼6%) of those with pancreatic cancer.9,10 Most of the data were acquired from randomized trials that included patients who were relatively fit. Only 1 case series of 55 patients with advanced pancreatic cancer suggested a prognostic relationship between the physical functioning scale scores of the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30) and survival.12

In the Netherlands, the Dutch Pancreatic Cancer Project (PACAP) was established in 2013. This is a multicenter cohort of patients with pancreatic and periampullary carcinoma for whom clinical data and PROMs are collected.13 We used this cohort to investigate the relationship between QoL and survival in daily clinical practice. The aim of this study was to examine which domains of QoL are predictive of survival in patients with pancreatic and periampullary cancer.

Original language	English
Pages (from-to)	1354-1363
Journal	Journal of the National Comprehensive Cancer Network
Volume	18
Issue number	10
DOIs	https://doi.org/10.6004/jnccn.2020.7579
Publication status	Published - 2020

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Mackay, T. M., Latenstein, A. E. J., Sprangers, M. A. G., Van Der Geest, L. G., Creemers, G., Van Dieren, S., De Groot, J. B., Groot Koerkamp, B., De Hingh, I. H., Homs, M. Y. V., De Jong, E. J. M., Molenaar, I. Q., Patijn, G. A., van de Poll-Franse, L. V., Van Santvoort, H. C., De Vos-geelen, J., Wilmink, J. W., Van Eijck, C. H., Besselink, M. G., ... _, . (2020). Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis. Journal of the National Comprehensive Cancer Network, 18(10), 1354-1363. https://doi.org/10.6004/jnccn.2020.7579

@article{7e31970f17d2410bb02d1c53061dc3ee,

title = "Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis",

abstract = "Patient-reported outcome measures (PROMs) are used increasingly in clinical practice to assess patients{\textquoteright} quality of life (QoL). Addressing QoL is important for patients with a short life expectancy, such as those with pancreatic and periampullary carcinoma, which has a median overall survival of 4 to 6 months.1 Different types of treatment that may improve survival in patients with pancreatic cancer may also impact QoL. Pancreatic resection has been found to be associated with a temporary deterioration in QoL, which usually returns to baseline values after 3 to 6 months.2,3 Moreover, chemotherapy has been found to improve QoL in randomized studies in the adjuvant and palliative setting.4,5QoL may also be used to predict survival. Previous studies with other types of cancer (eg, breast, lung, esophageal, liver) consistently found a correlation between QoL and survival.6–11 Previous studies combined patients with different types of cancer, including a limited number (∼6%) of those with pancreatic cancer.9,10 Most of the data were acquired from randomized trials that included patients who were relatively fit. Only 1 case series of 55 patients with advanced pancreatic cancer suggested a prognostic relationship between the physical functioning scale scores of the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30) and survival.12In the Netherlands, the Dutch Pancreatic Cancer Project (PACAP) was established in 2013. This is a multicenter cohort of patients with pancreatic and periampullary carcinoma for whom clinical data and PROMs are collected.13 We used this cohort to investigate the relationship between QoL and survival in daily clinical practice. The aim of this study was to examine which domains of QoL are predictive of survival in patients with pancreatic and periampullary cancer.",

author = "Mackay, {Tara M.} and Latenstein, {Anouk E.j.} and Sprangers, {Mirjam A.g.} and {Van Der Geest}, {Lydia G.} and Geert-jan Creemers and {Van Dieren}, Susan and {De Groot}, {Jan-willem B.} and {Groot Koerkamp}, Bas and {De Hingh}, {Ignace H.} and Homs, {Marjolein Y.v.} and {De Jong}, {Evelien J.m.} and Molenaar, {I. Quintus} and Patijn, {Gijs A.} and {van de Poll-Franse}, {Lonneke V.} and {Van Santvoort}, {Hjalmar C.} and {De Vos-geelen}, Judith and Wilmink, {Johanna W.} and {Van Eijck}, {Casper H.} and Besselink, {Marc G.} and {Van Laarhoven}, {Hanneke W.m.} and _ _",

year = "2020",

doi = "10.6004/jnccn.2020.7579",

language = "English",

volume = "18",

pages = "1354--1363",

journal = "Journal of the National Comprehensive Cancer Network",

issn = "1540-1405",

publisher = "Cold Spring Publishing LLC",

number = "10",

}

Mackay, TM, Latenstein, AEJ, Sprangers, MAG, Van Der Geest, LG, Creemers, G, Van Dieren, S, De Groot, JB, Groot Koerkamp, B, De Hingh, IH, Homs, MYV, De Jong, EJM, Molenaar, IQ, Patijn, GA, van de Poll-Franse, LV, Van Santvoort, HC, De Vos-geelen, J, Wilmink, JW, Van Eijck, CH, Besselink, MG, Van Laarhoven, HWM & _ 2020, 'Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis', Journal of the National Comprehensive Cancer Network, vol. 18, no. 10, pp. 1354-1363. https://doi.org/10.6004/jnccn.2020.7579

Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis. / Mackay, Tara M.; Latenstein, Anouk E.j.; Sprangers, Mirjam A.g. et al.
In: Journal of the National Comprehensive Cancer Network, Vol. 18, No. 10, 2020, p. 1354-1363.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Relationship between quality of life and survival in patients with pancreatic and periampullary cancer

T2 - A multicenter cohort analysis

AU - Mackay, Tara M.

AU - Latenstein, Anouk E.j.

AU - Sprangers, Mirjam A.g.

AU - Van Der Geest, Lydia G.

AU - Creemers, Geert-jan

AU - Van Dieren, Susan

AU - De Groot, Jan-willem B.

AU - Groot Koerkamp, Bas

AU - De Hingh, Ignace H.

AU - Homs, Marjolein Y.v.

AU - De Jong, Evelien J.m.

AU - Molenaar, I. Quintus

AU - Patijn, Gijs A.

AU - van de Poll-Franse, Lonneke V.

AU - Van Santvoort, Hjalmar C.

AU - De Vos-geelen, Judith

AU - Wilmink, Johanna W.

AU - Van Eijck, Casper H.

AU - Besselink, Marc G.

AU - Van Laarhoven, Hanneke W.m.

AU - _, _

PY - 2020

Y1 - 2020

N2 - Patient-reported outcome measures (PROMs) are used increasingly in clinical practice to assess patients’ quality of life (QoL). Addressing QoL is important for patients with a short life expectancy, such as those with pancreatic and periampullary carcinoma, which has a median overall survival of 4 to 6 months.1 Different types of treatment that may improve survival in patients with pancreatic cancer may also impact QoL. Pancreatic resection has been found to be associated with a temporary deterioration in QoL, which usually returns to baseline values after 3 to 6 months.2,3 Moreover, chemotherapy has been found to improve QoL in randomized studies in the adjuvant and palliative setting.4,5QoL may also be used to predict survival. Previous studies with other types of cancer (eg, breast, lung, esophageal, liver) consistently found a correlation between QoL and survival.6–11 Previous studies combined patients with different types of cancer, including a limited number (∼6%) of those with pancreatic cancer.9,10 Most of the data were acquired from randomized trials that included patients who were relatively fit. Only 1 case series of 55 patients with advanced pancreatic cancer suggested a prognostic relationship between the physical functioning scale scores of the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30) and survival.12In the Netherlands, the Dutch Pancreatic Cancer Project (PACAP) was established in 2013. This is a multicenter cohort of patients with pancreatic and periampullary carcinoma for whom clinical data and PROMs are collected.13 We used this cohort to investigate the relationship between QoL and survival in daily clinical practice. The aim of this study was to examine which domains of QoL are predictive of survival in patients with pancreatic and periampullary cancer.

AB - Patient-reported outcome measures (PROMs) are used increasingly in clinical practice to assess patients’ quality of life (QoL). Addressing QoL is important for patients with a short life expectancy, such as those with pancreatic and periampullary carcinoma, which has a median overall survival of 4 to 6 months.1 Different types of treatment that may improve survival in patients with pancreatic cancer may also impact QoL. Pancreatic resection has been found to be associated with a temporary deterioration in QoL, which usually returns to baseline values after 3 to 6 months.2,3 Moreover, chemotherapy has been found to improve QoL in randomized studies in the adjuvant and palliative setting.4,5QoL may also be used to predict survival. Previous studies with other types of cancer (eg, breast, lung, esophageal, liver) consistently found a correlation between QoL and survival.6–11 Previous studies combined patients with different types of cancer, including a limited number (∼6%) of those with pancreatic cancer.9,10 Most of the data were acquired from randomized trials that included patients who were relatively fit. Only 1 case series of 55 patients with advanced pancreatic cancer suggested a prognostic relationship between the physical functioning scale scores of the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30) and survival.12In the Netherlands, the Dutch Pancreatic Cancer Project (PACAP) was established in 2013. This is a multicenter cohort of patients with pancreatic and periampullary carcinoma for whom clinical data and PROMs are collected.13 We used this cohort to investigate the relationship between QoL and survival in daily clinical practice. The aim of this study was to examine which domains of QoL are predictive of survival in patients with pancreatic and periampullary cancer.

U2 - 10.6004/jnccn.2020.7579

DO - 10.6004/jnccn.2020.7579

M3 - Article

SN - 1540-1405

VL - 18

SP - 1354

EP - 1363

JO - Journal of the National Comprehensive Cancer Network

JF - Journal of the National Comprehensive Cancer Network

IS - 10

ER -

Relationship between quality of life and survival in patients with pancreatic and periampullary cancer: A multicenter cohort analysis

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