Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography: Implications for clinical practice

G. Kristo, A. Leemans, B. de Gelder, M. Raemaekers, G.J. Rutten, N.F. Ramsey

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objectives
To assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography (FT), which is a prerequisite for clinical applications of this technique. Here we assess the test–retest reproducibility of the architectural and microstructural features of two clinically relevant tracts reconstructed with DTI-FT.
Methods
The corticospinal tract (CST), arcuate fasciculus (AF) and its long segment (AFl) were reconstructed in 17 healthy subjects imaged twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract values were used to assess the microstructural reproducibility. Spatial correlation and fibre overlap were used to assess the architectural reproducibility.
Results
Spatial correlation was 68 % for the CST and AF, and 69 % for the AFl. Overlap was 69 % for the CST, 61 % for the AF, and 59 % for the AFl. This was comparable to 2-mm tract shift variability. CVs of diffusion-derived tract values were at most 3.4 %.
Conclusions
The results showed low architectural and microstructural variability for the reconstruction of the tracts. The architectural reproducibility results encourage the further investigation of the use of DTI-FT for neurosurgical planning. The high microstructural reproducibility results are promising for using DTI-FT in neurology to assess or predict functional recovery.
Original languageEnglish
Pages (from-to)28-36
JournalEuropean Radiology
Volume23
Issue number1
DOIs
Publication statusPublished - 2013

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Diffusion Tensor Imaging
Neurology

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Kristo, G. ; Leemans, A. ; de Gelder, B. ; Raemaekers, M. ; Rutten, G.J. ; Ramsey, N.F. / Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography : Implications for clinical practice. In: European Radiology. 2013 ; Vol. 23, No. 1. pp. 28-36.
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title = "Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography: Implications for clinical practice",
abstract = "ObjectivesTo assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography (FT), which is a prerequisite for clinical applications of this technique. Here we assess the test–retest reproducibility of the architectural and microstructural features of two clinically relevant tracts reconstructed with DTI-FT.MethodsThe corticospinal tract (CST), arcuate fasciculus (AF) and its long segment (AFl) were reconstructed in 17 healthy subjects imaged twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract values were used to assess the microstructural reproducibility. Spatial correlation and fibre overlap were used to assess the architectural reproducibility.ResultsSpatial correlation was 68 {\%} for the CST and AF, and 69 {\%} for the AFl. Overlap was 69 {\%} for the CST, 61 {\%} for the AF, and 59 {\%} for the AFl. This was comparable to 2-mm tract shift variability. CVs of diffusion-derived tract values were at most 3.4 {\%}.ConclusionsThe results showed low architectural and microstructural variability for the reconstruction of the tracts. The architectural reproducibility results encourage the further investigation of the use of DTI-FT for neurosurgical planning. The high microstructural reproducibility results are promising for using DTI-FT in neurology to assess or predict functional recovery.",
author = "G. Kristo and A. Leemans and {de Gelder}, B. and M. Raemaekers and G.J. Rutten and N.F. Ramsey",
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Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography : Implications for clinical practice. / Kristo, G.; Leemans, A.; de Gelder, B.; Raemaekers, M.; Rutten, G.J.; Ramsey, N.F.

In: European Radiology, Vol. 23, No. 1, 2013, p. 28-36.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography

T2 - Implications for clinical practice

AU - Kristo, G.

AU - Leemans, A.

AU - de Gelder, B.

AU - Raemaekers, M.

AU - Rutten, G.J.

AU - Ramsey, N.F.

PY - 2013

Y1 - 2013

N2 - ObjectivesTo assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography (FT), which is a prerequisite for clinical applications of this technique. Here we assess the test–retest reproducibility of the architectural and microstructural features of two clinically relevant tracts reconstructed with DTI-FT.MethodsThe corticospinal tract (CST), arcuate fasciculus (AF) and its long segment (AFl) were reconstructed in 17 healthy subjects imaged twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract values were used to assess the microstructural reproducibility. Spatial correlation and fibre overlap were used to assess the architectural reproducibility.ResultsSpatial correlation was 68 % for the CST and AF, and 69 % for the AFl. Overlap was 69 % for the CST, 61 % for the AF, and 59 % for the AFl. This was comparable to 2-mm tract shift variability. CVs of diffusion-derived tract values were at most 3.4 %.ConclusionsThe results showed low architectural and microstructural variability for the reconstruction of the tracts. The architectural reproducibility results encourage the further investigation of the use of DTI-FT for neurosurgical planning. The high microstructural reproducibility results are promising for using DTI-FT in neurology to assess or predict functional recovery.

AB - ObjectivesTo assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography (FT), which is a prerequisite for clinical applications of this technique. Here we assess the test–retest reproducibility of the architectural and microstructural features of two clinically relevant tracts reconstructed with DTI-FT.MethodsThe corticospinal tract (CST), arcuate fasciculus (AF) and its long segment (AFl) were reconstructed in 17 healthy subjects imaged twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract values were used to assess the microstructural reproducibility. Spatial correlation and fibre overlap were used to assess the architectural reproducibility.ResultsSpatial correlation was 68 % for the CST and AF, and 69 % for the AFl. Overlap was 69 % for the CST, 61 % for the AF, and 59 % for the AFl. This was comparable to 2-mm tract shift variability. CVs of diffusion-derived tract values were at most 3.4 %.ConclusionsThe results showed low architectural and microstructural variability for the reconstruction of the tracts. The architectural reproducibility results encourage the further investigation of the use of DTI-FT for neurosurgical planning. The high microstructural reproducibility results are promising for using DTI-FT in neurology to assess or predict functional recovery.

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SN - 0938-7994

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