Replication of Type 2 diabetes-associated variants in a Saudi Arabian population

Ruifang Li; Salma M Wakil; Brian F Meyer; Nduna Dzimiri; Dennis O Mook-Kanamori

doi:10.1152/physiolgenomics.00100.2017

Replication of Type 2 diabetes-associated variants in a Saudi Arabian population

Ruifang Li, Salma M Wakil, Brian F Meyer, Nduna Dzimiri, Dennis O Mook-Kanamori

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Over 120 Type 2 diabetes (T2D) loci have been identified from genome-wide association studies (GWAS), mainly from Caucasian populations. Very limited knowledge is available on the Saudi Arabian population. In this study, 122 previously reported T2D-related variants from 84 loci were examined in a Saudi Arabian cohort of 1,578 individuals (659 T2D cases and 919 controls). Eleven single nucleotide polymorphisms (SNPs) corresponding to nine independent loci had a P value <0.05. If a more stringent Bonferroni threshold of P = 4.1 × 10−4 ( = 0.05/122) were applied, none of the SNPs would have reached the significance level. Nine of the SNPs with a P value <0.05 showed similar odds ratios as previously described, but rs11605924 (CRY2) and rs9470794 (ZFAND3) were in the opposite direction. This study demonstrates the importance of large-scale GWAS in the Saudi Arabian population to identify ethnicity-specific disease-associated variants.

Original language	English
Pages (from-to)	296-297
Journal	Physiological genomics
Volume	50
Issue number	4
DOIs	https://doi.org/10.1152/physiolgenomics.00100.2017
Publication status	Published - 2018
Externally published	Yes

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title = "Replication of Type 2 diabetes-associated variants in a Saudi Arabian population",

abstract = "Over 120 Type 2 diabetes (T2D) loci have been identified from genome-wide association studies (GWAS), mainly from Caucasian populations. Very limited knowledge is available on the Saudi Arabian population. In this study, 122 previously reported T2D-related variants from 84 loci were examined in a Saudi Arabian cohort of 1,578 individuals (659 T2D cases and 919 controls). Eleven single nucleotide polymorphisms (SNPs) corresponding to nine independent loci had a P value <0.05. If a more stringent Bonferroni threshold of P = 4.1 × 10−4 ( = 0.05/122) were applied, none of the SNPs would have reached the significance level. Nine of the SNPs with a P value <0.05 showed similar odds ratios as previously described, but rs11605924 (CRY2) and rs9470794 (ZFAND3) were in the opposite direction. This study demonstrates the importance of large-scale GWAS in the Saudi Arabian population to identify ethnicity-specific disease-associated variants.",

author = "Ruifang Li and Wakil, {Salma M} and Meyer, {Brian F} and Nduna Dzimiri and Mook-Kanamori, {Dennis O}",

year = "2018",

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language = "English",

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T1 - Replication of Type 2 diabetes-associated variants in a Saudi Arabian population

AU - Li, Ruifang

AU - Wakil, Salma M

AU - Meyer, Brian F

AU - Dzimiri, Nduna

AU - Mook-Kanamori, Dennis O

PY - 2018

Y1 - 2018

N2 - Over 120 Type 2 diabetes (T2D) loci have been identified from genome-wide association studies (GWAS), mainly from Caucasian populations. Very limited knowledge is available on the Saudi Arabian population. In this study, 122 previously reported T2D-related variants from 84 loci were examined in a Saudi Arabian cohort of 1,578 individuals (659 T2D cases and 919 controls). Eleven single nucleotide polymorphisms (SNPs) corresponding to nine independent loci had a P value <0.05. If a more stringent Bonferroni threshold of P = 4.1 × 10−4 ( = 0.05/122) were applied, none of the SNPs would have reached the significance level. Nine of the SNPs with a P value <0.05 showed similar odds ratios as previously described, but rs11605924 (CRY2) and rs9470794 (ZFAND3) were in the opposite direction. This study demonstrates the importance of large-scale GWAS in the Saudi Arabian population to identify ethnicity-specific disease-associated variants.

AB - Over 120 Type 2 diabetes (T2D) loci have been identified from genome-wide association studies (GWAS), mainly from Caucasian populations. Very limited knowledge is available on the Saudi Arabian population. In this study, 122 previously reported T2D-related variants from 84 loci were examined in a Saudi Arabian cohort of 1,578 individuals (659 T2D cases and 919 controls). Eleven single nucleotide polymorphisms (SNPs) corresponding to nine independent loci had a P value <0.05. If a more stringent Bonferroni threshold of P = 4.1 × 10−4 ( = 0.05/122) were applied, none of the SNPs would have reached the significance level. Nine of the SNPs with a P value <0.05 showed similar odds ratios as previously described, but rs11605924 (CRY2) and rs9470794 (ZFAND3) were in the opposite direction. This study demonstrates the importance of large-scale GWAS in the Saudi Arabian population to identify ethnicity-specific disease-associated variants.

U2 - 10.1152/physiolgenomics.00100.2017

DO - 10.1152/physiolgenomics.00100.2017

M3 - Article

VL - 50

SP - 296

EP - 297

JO - Physiological genomics

JF - Physiological genomics

IS - 4

ER -

Replication of Type 2 diabetes-associated variants in a Saudi Arabian population

Abstract

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