Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer

C.J. van den Hurk, L.V. van de Poll-Franse, W.P.M. Breed, J.W.W. Coebergh, J. Nortier

Research output: Contribution to journalArticleScientificpeer-review

Abstract

With modern scalp cooling equipment cytotoxic damage of hair root cells can be prevented in half of the patients with cancer at high risk of alopecia. However, traditionally doubt has existed whether scalp cooling might facilitate hiding and disseminating scalp skin metastases and thus decrease survival. We discuss this risk using frequency data on metastases in breast cancer from observational and autopsy studies and the Munich cancer registry. They showed the incidence of scalp skin metastases to be very low and not differ between scalp-cooled (0.04–1%) and non scalp-cooled (0.03–3%) patients with breast cancer and in need of chemotherapy. We found it rather unlikely that the incidence of scalp skin metastases might increase at all after scalp cooling, whereas a very small proportion of patients receiving chemotherapy are at risk to develop metastases at this site. Scalp cooling can thus safely be offered to patients treated with alopecia-inducing chemotherapy.
Keywords: Scalp cooling, Safety, Scalp skin metastases
Original languageEnglish
Pages (from-to)1001-1004
JournalThe Breast
Volume22
Issue number5
DOIs
Publication statusPublished - 2013

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van den Hurk, C.J. ; van de Poll-Franse, L.V. ; Breed, W.P.M. ; Coebergh, J.W.W. ; Nortier, J. / Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer. In: The Breast. 2013 ; Vol. 22, No. 5. pp. 1001-1004.
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title = "Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer",
abstract = "With modern scalp cooling equipment cytotoxic damage of hair root cells can be prevented in half of the patients with cancer at high risk of alopecia. However, traditionally doubt has existed whether scalp cooling might facilitate hiding and disseminating scalp skin metastases and thus decrease survival. We discuss this risk using frequency data on metastases in breast cancer from observational and autopsy studies and the Munich cancer registry. They showed the incidence of scalp skin metastases to be very low and not differ between scalp-cooled (0.04–1{\%}) and non scalp-cooled (0.03–3{\%}) patients with breast cancer and in need of chemotherapy. We found it rather unlikely that the incidence of scalp skin metastases might increase at all after scalp cooling, whereas a very small proportion of patients receiving chemotherapy are at risk to develop metastases at this site. Scalp cooling can thus safely be offered to patients treated with alopecia-inducing chemotherapy.Keywords: Scalp cooling, Safety, Scalp skin metastases",
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doi = "10.1016/j.breast.2013.07.039",
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Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer. / van den Hurk, C.J.; van de Poll-Franse, L.V.; Breed, W.P.M.; Coebergh, J.W.W.; Nortier, J.

In: The Breast, Vol. 22, No. 5, 2013, p. 1001-1004.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer

AU - van den Hurk, C.J.

AU - van de Poll-Franse, L.V.

AU - Breed, W.P.M.

AU - Coebergh, J.W.W.

AU - Nortier, J.

PY - 2013

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AB - With modern scalp cooling equipment cytotoxic damage of hair root cells can be prevented in half of the patients with cancer at high risk of alopecia. However, traditionally doubt has existed whether scalp cooling might facilitate hiding and disseminating scalp skin metastases and thus decrease survival. We discuss this risk using frequency data on metastases in breast cancer from observational and autopsy studies and the Munich cancer registry. They showed the incidence of scalp skin metastases to be very low and not differ between scalp-cooled (0.04–1%) and non scalp-cooled (0.03–3%) patients with breast cancer and in need of chemotherapy. We found it rather unlikely that the incidence of scalp skin metastases might increase at all after scalp cooling, whereas a very small proportion of patients receiving chemotherapy are at risk to develop metastases at this site. Scalp cooling can thus safely be offered to patients treated with alopecia-inducing chemotherapy.Keywords: Scalp cooling, Safety, Scalp skin metastases

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