Screening op aneurysma aortae abdominalis: Effectiviteit en kosteneffectiviteit

Translated title of the contribution: Screening for abdominal aortic aneurysm; effectivity and cost-effectiveness

Paul F van Gils, G Ardine de Wit, A.J. Schuit, Matthijs van den Berg

Research output: Contribution to journalReview articleScientificpeer-review

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Abstract

Objective:

To review the current literature concerning the effectivity and cost-effectiveness of screening for abdominal aortic aneurysm (AAA).

Design:

Systematic review.

Method:

A review of literature of evaluations of effectivity via meta-analyses and economic evaluations.

Results:

The short-term meta-analyses showed that screening for AAA leads to a significant reduction of AAA-related mortality. The average absolute risk reduction (ARR) was 0.12%. The long-term meta-analysis also showed a significant reduction of overall mortality. The ARR was in this case almost 1%. The five economic evaluations all resulted in cost-effectiveness ratios below euro 20,000 per quality-adjusted life year (QALY), a used threshold level in the Netherlands.

Conclusion:

Based on the available literature, screening for AAA has appeared to be both effective and cost-effective. However, the economic evaluations did not always take into account the peri- and post-operative mortality and morbidity. Economic evaluations are only useful if all possible outcomes are included in the model. Therefore a good model analysis should be made for the Dutch situation, after which a decision may be taken on a possible pilot study and the optimal design thereof.

Original languageDutch
Article numberB383
JournalNederlandsch Tijdschrift voor Geneeskunde
Volume153
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Abdominal Aortic Aneurysm
Cost-Benefit Analysis
Quality-Adjusted Life Years
Netherlands

Keywords

  • Aortic Aneurysm, Abdominal
  • Aortic Rupture
  • Cost-Benefit Analysis
  • Humans
  • Life Expectancy
  • Mass Screening
  • Risk Assessment
  • Risk Factors
  • English Abstract
  • Journal Article
  • Meta-Analysis
  • Review

Cite this

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title = "Screening op aneurysma aortae abdominalis: Effectiviteit en kosteneffectiviteit",
abstract = "Objective: To review the current literature concerning the effectivity and cost-effectiveness of screening for abdominal aortic aneurysm (AAA).Design: Systematic review.Method: A review of literature of evaluations of effectivity via meta-analyses and economic evaluations.Results: The short-term meta-analyses showed that screening for AAA leads to a significant reduction of AAA-related mortality. The average absolute risk reduction (ARR) was 0.12{\%}. The long-term meta-analysis also showed a significant reduction of overall mortality. The ARR was in this case almost 1{\%}. The five economic evaluations all resulted in cost-effectiveness ratios below euro 20,000 per quality-adjusted life year (QALY), a used threshold level in the Netherlands.Conclusion: Based on the available literature, screening for AAA has appeared to be both effective and cost-effective. However, the economic evaluations did not always take into account the peri- and post-operative mortality and morbidity. Economic evaluations are only useful if all possible outcomes are included in the model. Therefore a good model analysis should be made for the Dutch situation, after which a decision may be taken on a possible pilot study and the optimal design thereof.",
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year = "2009",
language = "Dutch",
volume = "153",
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issn = "0028-2162",
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}

Screening op aneurysma aortae abdominalis : Effectiviteit en kosteneffectiviteit. / van Gils, Paul F; de Wit, G Ardine; Schuit, A.J.; van den Berg, Matthijs.

In: Nederlandsch Tijdschrift voor Geneeskunde, Vol. 153, B383, 2009.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Screening op aneurysma aortae abdominalis

T2 - Effectiviteit en kosteneffectiviteit

AU - van Gils, Paul F

AU - de Wit, G Ardine

AU - Schuit, A.J.

AU - van den Berg, Matthijs

PY - 2009

Y1 - 2009

N2 - Objective: To review the current literature concerning the effectivity and cost-effectiveness of screening for abdominal aortic aneurysm (AAA).Design: Systematic review.Method: A review of literature of evaluations of effectivity via meta-analyses and economic evaluations.Results: The short-term meta-analyses showed that screening for AAA leads to a significant reduction of AAA-related mortality. The average absolute risk reduction (ARR) was 0.12%. The long-term meta-analysis also showed a significant reduction of overall mortality. The ARR was in this case almost 1%. The five economic evaluations all resulted in cost-effectiveness ratios below euro 20,000 per quality-adjusted life year (QALY), a used threshold level in the Netherlands.Conclusion: Based on the available literature, screening for AAA has appeared to be both effective and cost-effective. However, the economic evaluations did not always take into account the peri- and post-operative mortality and morbidity. Economic evaluations are only useful if all possible outcomes are included in the model. Therefore a good model analysis should be made for the Dutch situation, after which a decision may be taken on a possible pilot study and the optimal design thereof.

AB - Objective: To review the current literature concerning the effectivity and cost-effectiveness of screening for abdominal aortic aneurysm (AAA).Design: Systematic review.Method: A review of literature of evaluations of effectivity via meta-analyses and economic evaluations.Results: The short-term meta-analyses showed that screening for AAA leads to a significant reduction of AAA-related mortality. The average absolute risk reduction (ARR) was 0.12%. The long-term meta-analysis also showed a significant reduction of overall mortality. The ARR was in this case almost 1%. The five economic evaluations all resulted in cost-effectiveness ratios below euro 20,000 per quality-adjusted life year (QALY), a used threshold level in the Netherlands.Conclusion: Based on the available literature, screening for AAA has appeared to be both effective and cost-effective. However, the economic evaluations did not always take into account the peri- and post-operative mortality and morbidity. Economic evaluations are only useful if all possible outcomes are included in the model. Therefore a good model analysis should be made for the Dutch situation, after which a decision may be taken on a possible pilot study and the optimal design thereof.

KW - Aortic Aneurysm, Abdominal

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KW - Cost-Benefit Analysis

KW - Humans

KW - Life Expectancy

KW - Mass Screening

KW - Risk Assessment

KW - Risk Factors

KW - English Abstract

KW - Journal Article

KW - Meta-Analysis

KW - Review

M3 - Review article

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JO - Nederlandsch Tijdschrift voor Geneeskunde

JF - Nederlandsch Tijdschrift voor Geneeskunde

SN - 0028-2162

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