Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease

Tina Birgitte Hansen, Lau Caspar Thygesen, Ann Dorthe Zwisler, Lotte Helmark, Madelein Hoogwegt, Henneke Versteeg, Stefan Höfer, Neil Oldridge

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background 
Patient health-related quality of life (HRQL) is an important health outcome with lower HRQL associated with adverse events in patients with ischaemic heart disease (IHD).Design Baseline health-related quality of life was investigated as a predictor of 5-year all-cause mortality and cardiac readmissions in Danish patients with IHD.
Methods 
The international HeartQoL Project survey was designed to develop a core HRQL questionnaire for patients with IHD. Baseline scores on each of the 14 items ultimately included in the HeartQoL questionnaire were linked to Danish national health registries and hazard ratios for mortality and readmissions were estimated using Cox regression models.Results Among 938 eligible Danish patients with IHD, 662 (70.6%) participated in the international HeartQoL Project. During the 5-year follow-up, 83 patients died and 196 patients were readmitted. Adjusted analyses showed a significant linear association between all-cause mortality and both lower global HRQL (HR = 1.67, 95% CI: 1.26–2.23; p < 0.001) and physical scores (HR = 1.71, 1.33–2.21; p < 0.001) and between readmission and both lower global (HR = 1.73, 1.41–2.12; p < 0.001) and physical scores (HR = 1.63, 1.35–1.96; p < 0.001). A significant, but non-linear, effect was found for emotional HRQL score on outcomes.
Conclusion 
This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission.
Original languageEnglish
Pages (from-to)882-889
JournalEuropean Journal of Preventive Cardiology
Volume22
Issue number7
DOIs
Publication statusPublished - 2015

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Patient Readmission
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Hansen, Tina Birgitte ; Thygesen, Lau Caspar ; Zwisler, Ann Dorthe ; Helmark, Lotte ; Hoogwegt, Madelein ; Versteeg, Henneke ; Höfer, Stefan ; Oldridge, Neil. / Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease. In: European Journal of Preventive Cardiology. 2015 ; Vol. 22, No. 7. pp. 882-889.
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title = "Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease",
abstract = "Background Patient health-related quality of life (HRQL) is an important health outcome with lower HRQL associated with adverse events in patients with ischaemic heart disease (IHD).Design Baseline health-related quality of life was investigated as a predictor of 5-year all-cause mortality and cardiac readmissions in Danish patients with IHD.Methods The international HeartQoL Project survey was designed to develop a core HRQL questionnaire for patients with IHD. Baseline scores on each of the 14 items ultimately included in the HeartQoL questionnaire were linked to Danish national health registries and hazard ratios for mortality and readmissions were estimated using Cox regression models.Results Among 938 eligible Danish patients with IHD, 662 (70.6{\%}) participated in the international HeartQoL Project. During the 5-year follow-up, 83 patients died and 196 patients were readmitted. Adjusted analyses showed a significant linear association between all-cause mortality and both lower global HRQL (HR = 1.67, 95{\%} CI: 1.26–2.23; p < 0.001) and physical scores (HR = 1.71, 1.33–2.21; p < 0.001) and between readmission and both lower global (HR = 1.73, 1.41–2.12; p < 0.001) and physical scores (HR = 1.63, 1.35–1.96; p < 0.001). A significant, but non-linear, effect was found for emotional HRQL score on outcomes.Conclusion This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission.",
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Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease. / Hansen, Tina Birgitte; Thygesen, Lau Caspar; Zwisler, Ann Dorthe; Helmark, Lotte; Hoogwegt, Madelein; Versteeg, Henneke; Höfer, Stefan; Oldridge, Neil.

In: European Journal of Preventive Cardiology, Vol. 22, No. 7, 2015, p. 882-889.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease

AU - Hansen, Tina Birgitte

AU - Thygesen, Lau Caspar

AU - Zwisler, Ann Dorthe

AU - Helmark, Lotte

AU - Hoogwegt, Madelein

AU - Versteeg, Henneke

AU - Höfer, Stefan

AU - Oldridge, Neil

PY - 2015

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N2 - Background Patient health-related quality of life (HRQL) is an important health outcome with lower HRQL associated with adverse events in patients with ischaemic heart disease (IHD).Design Baseline health-related quality of life was investigated as a predictor of 5-year all-cause mortality and cardiac readmissions in Danish patients with IHD.Methods The international HeartQoL Project survey was designed to develop a core HRQL questionnaire for patients with IHD. Baseline scores on each of the 14 items ultimately included in the HeartQoL questionnaire were linked to Danish national health registries and hazard ratios for mortality and readmissions were estimated using Cox regression models.Results Among 938 eligible Danish patients with IHD, 662 (70.6%) participated in the international HeartQoL Project. During the 5-year follow-up, 83 patients died and 196 patients were readmitted. Adjusted analyses showed a significant linear association between all-cause mortality and both lower global HRQL (HR = 1.67, 95% CI: 1.26–2.23; p < 0.001) and physical scores (HR = 1.71, 1.33–2.21; p < 0.001) and between readmission and both lower global (HR = 1.73, 1.41–2.12; p < 0.001) and physical scores (HR = 1.63, 1.35–1.96; p < 0.001). A significant, but non-linear, effect was found for emotional HRQL score on outcomes.Conclusion This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission.

AB - Background Patient health-related quality of life (HRQL) is an important health outcome with lower HRQL associated with adverse events in patients with ischaemic heart disease (IHD).Design Baseline health-related quality of life was investigated as a predictor of 5-year all-cause mortality and cardiac readmissions in Danish patients with IHD.Methods The international HeartQoL Project survey was designed to develop a core HRQL questionnaire for patients with IHD. Baseline scores on each of the 14 items ultimately included in the HeartQoL questionnaire were linked to Danish national health registries and hazard ratios for mortality and readmissions were estimated using Cox regression models.Results Among 938 eligible Danish patients with IHD, 662 (70.6%) participated in the international HeartQoL Project. During the 5-year follow-up, 83 patients died and 196 patients were readmitted. Adjusted analyses showed a significant linear association between all-cause mortality and both lower global HRQL (HR = 1.67, 95% CI: 1.26–2.23; p < 0.001) and physical scores (HR = 1.71, 1.33–2.21; p < 0.001) and between readmission and both lower global (HR = 1.73, 1.41–2.12; p < 0.001) and physical scores (HR = 1.63, 1.35–1.96; p < 0.001). A significant, but non-linear, effect was found for emotional HRQL score on outcomes.Conclusion This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission.

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DO - 10.1177/2047487314535682

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SN - 2047-4873

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