Serum cholesterol decline and depression in the postpartum period

R M van Dam, A.J. Schuit, E G Schouten, H L Vader, V.J. Pop

    Research output: Contribution to journalArticleScientificpeer-review

    23 Citations (Scopus)


    We examined the relation between total serum cholesterol decline and depression in the postpartum period in a prospective study of 266 Dutch women, who were followed until 34 weeks after delivery. The decline in serum cholesterol between week 32 of pregnancy and week 10 postpartum was similar for women who became depressed (n = 63) in the subsequent period and women who did not (difference, 0.10 mmol/l; 95% confidence interval [CI] -0.16 to 0.37). Adjusting for age, multiparity, education level, smoking status, concurrent illness, and social support, the odds ratio of depression was 1.4 (95% CI, 0.64 to 2.9) for women in the highest tertile of serum cholesterol decline and 0.61 (95% CI, 0.28 to 1.3) for women in the intermediate tertile, as compared with women in the lowest tertile. Our results do not support the hypothesis that rapid serum cholesterol decline increases risk of depression in the postpartum period.

    Original languageEnglish
    Pages (from-to)385-390
    JournalJournal of Psychosomatic Research
    Issue number4
    Publication statusPublished - Apr 1999


    • Adult
    • Breast Feeding
    • Cholesterol
    • Depression, Postpartum
    • Female
    • Humans
    • Longitudinal Studies
    • Odds Ratio
    • Postpartum Period
    • Pregnancy
    • Prospective Studies
    • Risk Assessment
    • Social Support
    • Clinical Trial
    • Comparative Study
    • Journal Article
    • Research Support, Non-U.S. Gov't


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