Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)

Konstantinos N. Fountoulakis; Grigorios N. Karakatsoulis; Seri Abraham; Kristina Adorjan; Helal Uddin Ahmed; Renato D. Alarcon; Kiyomi Arai; Sani Salihu Auwal; Michael Berk; Sarah Bjedov; Julio Bobes; Teresa Bobes-Bascaran; Julie Bourgin-Duchesnay; Cristina Ana Bredicean; Laurynas Bukelskis; Akaki Burkadze; Indira Indiana Cabrera Abud; Ruby Castilla-Puentes; Marcelo Cetkovich; Hector Colon-Rivera; Ricardo Corral; Carla Cortez-Vergara; Piirika Crepin; Domenico De Berardis; Sergio Zamora Delgado; David De Lucena; Avinash De Sousa; Ramona Di Stefano; Seetal Dodd; Livia Priyanka Elek; Anna Elissa; Berta Erdelyi-Hamza; Gamze Erzin; Martin J. Etchevers; Peter Falkai; Adriana Farcas; Ilya Fedotov; Viktoriia Filatova; Nikolaos K. Fountoulakis; Iryna Frankova; Francesco Franza; Pedro Frias; Tatiana Galako; Cristian J. Garay; Leticia Garcia-Alvarez; Maria Paz Garcia-Portilla; Xenia Gonda; Tomasz M. Gondek; Daniela Morera Gonzalez; Hilary Gould; Paolo Grandinetti; Arturo Grau; Violeta Groudeva; Michal Hagin; Takayuki Harada; Tasdik M. Hasan; Nurul Azreen Hashim; Jan Hilbig; Sahadat Hossain; Rossitza Iakimova; Mona Ibrahim; Felicia Iftene; Yulia Ignatenko; Matias Irarrazaval; Zaliha Ismail; Jamila Ismayilova; Asaf Jakobs; Miro Jakovljevic; Nenad Jaksic; Afzal Javed; Helin Yilmaz Kafali; Sagar Karia; Olga Kazakova; Doaa Khalifa; Olena Khaustova; Steve Koh; Svetlana Kopishinskaia; Korneliia Kosenko; Sotirios A. Koupidis; Illes Kovacs; Barbara Kulig; Alisha Lalljee; Justine Liewig; Abdul Majid; Evgeniia Malashonkova; Khamelia Malik; Najma Iqbal Malik; Gulay Mammadzada; Bilvesh Mandalia; Donatella Marazziti; Darko Marcinko; Stephanie Martinez; Eimantas Matiekus; Gabriela Mejia; Roha Saeed Memon; Xarah Elenne Meza Martinez; Dalia Mickeviciute; Roumen Milev; Muftau Mohammed; Alejandro Molina-Lopez; Petr Morozov; Nuru Suleiman Muhammad; Filip Mustac; Mika S. Naor; Amira Nassieb; Alvydas Navickas; Tarek Okasha; Milena Pandova; Anca-Livia Panfil; Liliya Panteleeva; Ion Papava; Mikaella E. Patsali; Alexey Pavlichenko; Bojana Pejuskovic; Mariana Pinto Da Costa; Mikhail Popkov; Dina Popovic; Nor Jannah Nasution Raduan; Francisca Vargas Ramirez; Elmars Rancans; Salmi Razali; Federico Rebok; Anna Rewekant; Elena Ninoska Reyes Flores; Maria Teresa Rivera-Encinas; Pilar Saiz; Manuel Sanchez de Carmona; David Saucedo Martinez; Jo Anne Saw; Gorkem Saygili; Patricia Schneidereit; Bhumika Shah; Tomohiro Shirasaka; Ketevan Silagadze; Satti Sitanggang; Oleg Skugarevsky; Anna Spikina; Sridevi Sira Mahalingappa; Maria Stoyanova; Anna Szczegielniak; Simona Claudia Tamasan; Giuseppe Tavormina; Maurilio Giuseppe Maria Tavormina; Pavlos N. Theodorakis; Mauricio Tohen; Eva Maria Tsapakis; Dina Tukhvatullina; Irfan Ullah; Ratnaraj Vaidya; Johann M. Vega-Dienstmaier; Jelena Vrublevska; Olivera Vukovic; Olga Vysotska; Natalia Widiasih; Anna Yashikhina; Panagiotis E. Prezerakos; Daria Smirnova

doi:10.1017/S1092852924000026

Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)

Konstantinos N. Fountoulakis, Grigorios N. Karakatsoulis, Seri Abraham, Kristina Adorjan, Helal Uddin Ahmed, Renato D. Alarcon, Kiyomi Arai, Sani Salihu Auwal, Michael Berk, Sarah Bjedov, Julio Bobes, Teresa Bobes-Bascaran, Julie Bourgin-Duchesnay, Cristina Ana Bredicean, Laurynas Bukelskis, Akaki Burkadze, Indira Indiana Cabrera Abud, Ruby Castilla-Puentes, Marcelo Cetkovich, Hector Colon-RiveraRicardo Corral, Carla Cortez-Vergara, Piirika Crepin, Domenico De Berardis, Sergio Zamora Delgado, David De Lucena, Avinash De Sousa, Ramona Di Stefano, Seetal Dodd, Livia Priyanka Elek, Anna Elissa, Berta Erdelyi-Hamza, Gamze Erzin, Martin J. Etchevers, Peter Falkai, Adriana Farcas, Ilya Fedotov, Viktoriia Filatova, Nikolaos K. Fountoulakis, Iryna Frankova, Francesco Franza, Pedro Frias, Tatiana Galako, Cristian J. Garay, Leticia Garcia-Alvarez, Maria Paz Garcia-Portilla, Xenia Gonda, Tomasz M. Gondek, Daniela Morera Gonzalez, Hilary Gould, Paolo Grandinetti, Arturo Grau, Violeta Groudeva, Michal Hagin, Takayuki Harada, Tasdik M. Hasan, Nurul Azreen Hashim, Jan Hilbig, Sahadat Hossain, Rossitza Iakimova, Mona Ibrahim, Felicia Iftene, Yulia Ignatenko, Matias Irarrazaval, Zaliha Ismail, Jamila Ismayilova, Asaf Jakobs, Miro Jakovljevic, Nenad Jaksic, Afzal Javed, Helin Yilmaz Kafali, Sagar Karia, Olga Kazakova, Doaa Khalifa, Olena Khaustova, Steve Koh, Svetlana Kopishinskaia, Korneliia Kosenko, Sotirios A. Koupidis, Illes Kovacs, Barbara Kulig, Alisha Lalljee, Justine Liewig, Abdul Majid, Evgeniia Malashonkova, Khamelia Malik, Najma Iqbal Malik, Gulay Mammadzada, Bilvesh Mandalia, Donatella Marazziti, Darko Marcinko, Stephanie Martinez, Eimantas Matiekus, Gabriela Mejia, Roha Saeed Memon, Xarah Elenne Meza Martinez, Dalia Mickeviciute, Roumen Milev, Muftau Mohammed, Alejandro Molina-Lopez, Petr Morozov, Nuru Suleiman Muhammad, Filip Mustac, Mika S. Naor, Amira Nassieb, Alvydas Navickas, Tarek Okasha, Milena Pandova, Anca-Livia Panfil, Liliya Panteleeva, Ion Papava, Mikaella E. Patsali, Alexey Pavlichenko, Bojana Pejuskovic, Mariana Pinto Da Costa, Mikhail Popkov, Dina Popovic, Nor Jannah Nasution Raduan, Francisca Vargas Ramirez, Elmars Rancans, Salmi Razali, Federico Rebok, Anna Rewekant, Elena Ninoska Reyes Flores, Maria Teresa Rivera-Encinas, Pilar Saiz, Manuel Sanchez de Carmona, David Saucedo Martinez, Jo Anne Saw, Gorkem Saygili, Patricia Schneidereit, Bhumika Shah, Tomohiro Shirasaka, Ketevan Silagadze, Satti Sitanggang, Oleg Skugarevsky, Anna Spikina, Sridevi Sira Mahalingappa, Maria Stoyanova, Anna Szczegielniak, Simona Claudia Tamasan, Giuseppe Tavormina, Maurilio Giuseppe Maria Tavormina, Pavlos N. Theodorakis, Mauricio Tohen, Eva Maria Tsapakis, Dina Tukhvatullina, Irfan Ullah, Ratnaraj Vaidya, Johann M. Vega-Dienstmaier, Jelena Vrublevska, Olivera Vukovic, Olga Vysotska, Natalia Widiasih, Anna Yashikhina, Panagiotis E. Prezerakos, Daria Smirnova

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.Methods The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions.Results About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome.Conclusions The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.

Original language	English
Pages (from-to)	126-149
Number of pages	24
Journal	CNS Spectrums
Volume	29
Issue number	2
Early online date	Jan 2024
DOIs	https://doi.org/10.1017/S1092852924000026
Publication status	Published - Apr 2024
Externally published	Yes

Keywords

Epidemiology
Disability
Multicomorbidity
Premature death
Somatic-mental comorbidity

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10.1017/S1092852924000026

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Fountoulakis, K. N., Karakatsoulis, G. N., Abraham, S., Adorjan, K., Ahmed, H. U., Alarcon, R. D., Arai, K., Auwal, S. S., Berk, M., Bjedov, S., Bobes, J., Bobes-Bascaran, T., Bourgin-Duchesnay, J., Bredicean, C. A., Bukelskis, L., Burkadze, A., Cabrera Abud, I. I., Castilla-Puentes, R., Cetkovich, M., ... Smirnova, D. (2024). Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study). CNS Spectrums, 29(2), 126-149. https://doi.org/10.1017/S1092852924000026

@article{a800b030bd1c467583b53003f050c751,

title = "Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)",

abstract = "Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.Methods The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions.Results About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome.Conclusions The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.",

keywords = "Epidemiology, Disability, Multicomorbidity, Premature death, Somatic-mental comorbidity",

author = "Fountoulakis, {Konstantinos N.} and Karakatsoulis, {Grigorios N.} and Seri Abraham and Kristina Adorjan and Ahmed, {Helal Uddin} and Alarcon, {Renato D.} and Kiyomi Arai and Auwal, {Sani Salihu} and Michael Berk and Sarah Bjedov and Julio Bobes and Teresa Bobes-Bascaran and Julie Bourgin-Duchesnay and Bredicean, {Cristina Ana} and Laurynas Bukelskis and Akaki Burkadze and {Cabrera Abud}, {Indira Indiana} and Ruby Castilla-Puentes and Marcelo Cetkovich and Hector Colon-Rivera and Ricardo Corral and Carla Cortez-Vergara and Piirika Crepin and {De Berardis}, Domenico and {Zamora Delgado}, Sergio and {De Lucena}, David and {De Sousa}, Avinash and {Di Stefano}, Ramona and Seetal Dodd and Elek, {Livia Priyanka} and Anna Elissa and Berta Erdelyi-Hamza and Gamze Erzin and Etchevers, {Martin J.} and Peter Falkai and Adriana Farcas and Ilya Fedotov and Viktoriia Filatova and Fountoulakis, {Nikolaos K.} and Iryna Frankova and Francesco Franza and Pedro Frias and Tatiana Galako and Garay, {Cristian J.} and Leticia Garcia-Alvarez and {Paz Garcia-Portilla}, Maria and Xenia Gonda and Gondek, {Tomasz M.} and {Morera Gonzalez}, Daniela and Hilary Gould and Paolo Grandinetti and Arturo Grau and Violeta Groudeva and Michal Hagin and Takayuki Harada and Hasan, {Tasdik M.} and Hashim, {Nurul Azreen} and Jan Hilbig and Sahadat Hossain and Rossitza Iakimova and Mona Ibrahim and Felicia Iftene and Yulia Ignatenko and Matias Irarrazaval and Zaliha Ismail and Jamila Ismayilova and Asaf Jakobs and Miro Jakovljevic and Nenad Jaksic and Afzal Javed and Kafali, {Helin Yilmaz} and Sagar Karia and Olga Kazakova and Doaa Khalifa and Olena Khaustova and Steve Koh and Svetlana Kopishinskaia and Korneliia Kosenko and Koupidis, {Sotirios A.} and Illes Kovacs and Barbara Kulig and Alisha Lalljee and Justine Liewig and Abdul Majid and Evgeniia Malashonkova and Khamelia Malik and Malik, {Najma Iqbal} and Gulay Mammadzada and Bilvesh Mandalia and Donatella Marazziti and Darko Marcinko and Stephanie Martinez and Eimantas Matiekus and Gabriela Mejia and Memon, {Roha Saeed} and {Meza Martinez}, {Xarah Elenne} and Dalia Mickeviciute and Roumen Milev and Muftau Mohammed and Alejandro Molina-Lopez and Petr Morozov and Muhammad, {Nuru Suleiman} and Filip Mustac and Naor, {Mika S.} and Amira Nassieb and Alvydas Navickas and Tarek Okasha and Milena Pandova and Anca-Livia Panfil and Liliya Panteleeva and Ion Papava and Patsali, {Mikaella E.} and Alexey Pavlichenko and Bojana Pejuskovic and {Da Costa}, {Mariana Pinto} and Mikhail Popkov and Dina Popovic and Raduan, {Nor Jannah Nasution} and {Vargas Ramirez}, Francisca and Elmars Rancans and Salmi Razali and Federico Rebok and Anna Rewekant and {Reyes Flores}, {Elena Ninoska} and {Teresa Rivera-Encinas}, Maria and Pilar Saiz and {Sanchez de Carmona}, Manuel and {Saucedo Martinez}, David and Saw, {Jo Anne} and Gorkem Saygili and Patricia Schneidereit and Bhumika Shah and Tomohiro Shirasaka and Ketevan Silagadze and Satti Sitanggang and Oleg Skugarevsky and Anna Spikina and Mahalingappa, {Sridevi Sira} and Maria Stoyanova and Anna Szczegielniak and Tamasan, {Simona Claudia} and Giuseppe Tavormina and Tavormina, {Maurilio Giuseppe Maria} and Theodorakis, {Pavlos N.} and Mauricio Tohen and Tsapakis, {Eva Maria} and Dina Tukhvatullina and Irfan Ullah and Ratnaraj Vaidya and Vega-Dienstmaier, {Johann M.} and Jelena Vrublevska and Olivera Vukovic and Olga Vysotska and Natalia Widiasih and Anna Yashikhina and Prezerakos, {Panagiotis E.} and Daria Smirnova",

year = "2024",

month = apr,

doi = "10.1017/S1092852924000026",

language = "English",

volume = "29",

pages = "126--149",

journal = "CNS Spectrums",

issn = "1092-8529",

publisher = "Cambridge University Press",

number = "2",

}

Fountoulakis, KN, Karakatsoulis, GN, Abraham, S, Adorjan, K, Ahmed, HU, Alarcon, RD, Arai, K, Auwal, SS, Berk, M, Bjedov, S, Bobes, J, Bobes-Bascaran, T, Bourgin-Duchesnay, J, Bredicean, CA, Bukelskis, L, Burkadze, A, Cabrera Abud, II, Castilla-Puentes, R, Cetkovich, M, Colon-Rivera, H, Corral, R, Cortez-Vergara, C, Crepin, P, De Berardis, D, Zamora Delgado, S, De Lucena, D, De Sousa, A, Di Stefano, R, Dodd, S, Elek, LP, Elissa, A, Erdelyi-Hamza, B, Erzin, G, Etchevers, MJ, Falkai, P, Farcas, A, Fedotov, I, Filatova, V, Fountoulakis, NK, Frankova, I, Franza, F, Frias, P, Galako, T, Garay, CJ, Garcia-Alvarez, L, Paz Garcia-Portilla, M, Gonda, X, Gondek, TM, Morera Gonzalez, D, Gould, H, Grandinetti, P, Grau, A, Groudeva, V, Hagin, M, Harada, T, Hasan, TM, Hashim, NA, Hilbig, J, Hossain, S, Iakimova, R, Ibrahim, M, Iftene, F, Ignatenko, Y, Irarrazaval, M, Ismail, Z, Ismayilova, J, Jakobs, A, Jakovljevic, M, Jaksic, N, Javed, A, Kafali, HY, Karia, S, Kazakova, O, Khalifa, D, Khaustova, O, Koh, S, Kopishinskaia, S, Kosenko, K, Koupidis, SA, Kovacs, I, Kulig, B, Lalljee, A, Liewig, J, Majid, A, Malashonkova, E, Malik, K, Malik, NI, Mammadzada, G, Mandalia, B, Marazziti, D, Marcinko, D, Martinez, S, Matiekus, E, Mejia, G, Memon, RS, Meza Martinez, XE, Mickeviciute, D, Milev, R, Mohammed, M, Molina-Lopez, A, Morozov, P, Muhammad, NS, Mustac, F, Naor, MS, Nassieb, A, Navickas, A, Okasha, T, Pandova, M, Panfil, A-L, Panteleeva, L, Papava, I, Patsali, ME, Pavlichenko, A, Pejuskovic, B, Da Costa, MP, Popkov, M, Popovic, D, Raduan, NJN, Vargas Ramirez, F, Rancans, E, Razali, S, Rebok, F, Rewekant, A, Reyes Flores, EN, Teresa Rivera-Encinas, M, Saiz, P, Sanchez de Carmona, M, Saucedo Martinez, D, Saw, JA, Saygili, G, Schneidereit, P, Shah, B, Shirasaka, T, Silagadze, K, Sitanggang, S, Skugarevsky, O, Spikina, A, Mahalingappa, SS, Stoyanova, M, Szczegielniak, A, Tamasan, SC, Tavormina, G, Tavormina, MGM, Theodorakis, PN, Tohen, M, Tsapakis, EM, Tukhvatullina, D, Ullah, I, Vaidya, R, Vega-Dienstmaier, JM, Vrublevska, J, Vukovic, O, Vysotska, O, Widiasih, N, Yashikhina, A, Prezerakos, PE & Smirnova, D 2024, 'Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)', CNS Spectrums, vol. 29, no. 2, pp. 126-149. https://doi.org/10.1017/S1092852924000026

Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study). / Fountoulakis, Konstantinos N.; Karakatsoulis, Grigorios N.; Abraham, Seri et al.
In: CNS Spectrums, Vol. 29, No. 2, 04.2024, p. 126-149.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population

T2 - a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)

AU - Fountoulakis, Konstantinos N.

AU - Karakatsoulis, Grigorios N.

AU - Abraham, Seri

AU - Adorjan, Kristina

AU - Ahmed, Helal Uddin

AU - Alarcon, Renato D.

AU - Arai, Kiyomi

AU - Auwal, Sani Salihu

AU - Berk, Michael

AU - Bjedov, Sarah

AU - Bobes, Julio

AU - Bobes-Bascaran, Teresa

AU - Bourgin-Duchesnay, Julie

AU - Bredicean, Cristina Ana

AU - Bukelskis, Laurynas

AU - Burkadze, Akaki

AU - Cabrera Abud, Indira Indiana

AU - Castilla-Puentes, Ruby

AU - Cetkovich, Marcelo

AU - Colon-Rivera, Hector

AU - Corral, Ricardo

AU - Cortez-Vergara, Carla

AU - Crepin, Piirika

AU - De Berardis, Domenico

AU - Zamora Delgado, Sergio

AU - De Lucena, David

AU - De Sousa, Avinash

AU - Di Stefano, Ramona

AU - Dodd, Seetal

AU - Elek, Livia Priyanka

AU - Elissa, Anna

AU - Erdelyi-Hamza, Berta

AU - Erzin, Gamze

AU - Etchevers, Martin J.

AU - Falkai, Peter

AU - Farcas, Adriana

AU - Fedotov, Ilya

AU - Filatova, Viktoriia

AU - Fountoulakis, Nikolaos K.

AU - Frankova, Iryna

AU - Franza, Francesco

AU - Frias, Pedro

AU - Galako, Tatiana

AU - Garay, Cristian J.

AU - Garcia-Alvarez, Leticia

AU - Paz Garcia-Portilla, Maria

AU - Gonda, Xenia

AU - Gondek, Tomasz M.

AU - Morera Gonzalez, Daniela

AU - Gould, Hilary

AU - Grandinetti, Paolo

AU - Grau, Arturo

AU - Groudeva, Violeta

AU - Hagin, Michal

AU - Harada, Takayuki

AU - Hasan, Tasdik M.

AU - Hashim, Nurul Azreen

AU - Hilbig, Jan

AU - Hossain, Sahadat

AU - Iakimova, Rossitza

AU - Ibrahim, Mona

AU - Iftene, Felicia

AU - Ignatenko, Yulia

AU - Irarrazaval, Matias

AU - Ismail, Zaliha

AU - Ismayilova, Jamila

AU - Jakobs, Asaf

AU - Jakovljevic, Miro

AU - Jaksic, Nenad

AU - Javed, Afzal

AU - Kafali, Helin Yilmaz

AU - Karia, Sagar

AU - Kazakova, Olga

AU - Khalifa, Doaa

AU - Khaustova, Olena

AU - Koh, Steve

AU - Kopishinskaia, Svetlana

AU - Kosenko, Korneliia

AU - Koupidis, Sotirios A.

AU - Kovacs, Illes

AU - Kulig, Barbara

AU - Lalljee, Alisha

AU - Liewig, Justine

AU - Majid, Abdul

AU - Malashonkova, Evgeniia

AU - Malik, Khamelia

AU - Malik, Najma Iqbal

AU - Mammadzada, Gulay

AU - Mandalia, Bilvesh

AU - Marazziti, Donatella

AU - Marcinko, Darko

AU - Martinez, Stephanie

AU - Matiekus, Eimantas

AU - Mejia, Gabriela

AU - Memon, Roha Saeed

AU - Meza Martinez, Xarah Elenne

AU - Mickeviciute, Dalia

AU - Milev, Roumen

AU - Mohammed, Muftau

AU - Molina-Lopez, Alejandro

AU - Morozov, Petr

AU - Muhammad, Nuru Suleiman

AU - Mustac, Filip

AU - Naor, Mika S.

AU - Nassieb, Amira

AU - Navickas, Alvydas

AU - Okasha, Tarek

AU - Pandova, Milena

AU - Panfil, Anca-Livia

AU - Panteleeva, Liliya

AU - Papava, Ion

AU - Patsali, Mikaella E.

AU - Pavlichenko, Alexey

AU - Pejuskovic, Bojana

AU - Da Costa, Mariana Pinto

AU - Popkov, Mikhail

AU - Popovic, Dina

AU - Raduan, Nor Jannah Nasution

AU - Vargas Ramirez, Francisca

AU - Rancans, Elmars

AU - Razali, Salmi

AU - Rebok, Federico

AU - Rewekant, Anna

AU - Reyes Flores, Elena Ninoska

AU - Teresa Rivera-Encinas, Maria

AU - Saiz, Pilar

AU - Sanchez de Carmona, Manuel

AU - Saucedo Martinez, David

AU - Saw, Jo Anne

AU - Saygili, Gorkem

AU - Schneidereit, Patricia

AU - Shah, Bhumika

AU - Shirasaka, Tomohiro

AU - Silagadze, Ketevan

AU - Sitanggang, Satti

AU - Skugarevsky, Oleg

AU - Spikina, Anna

AU - Mahalingappa, Sridevi Sira

AU - Stoyanova, Maria

AU - Szczegielniak, Anna

AU - Tamasan, Simona Claudia

AU - Tavormina, Giuseppe

AU - Tavormina, Maurilio Giuseppe Maria

AU - Theodorakis, Pavlos N.

AU - Tohen, Mauricio

AU - Tsapakis, Eva Maria

AU - Tukhvatullina, Dina

AU - Ullah, Irfan

AU - Vaidya, Ratnaraj

AU - Vega-Dienstmaier, Johann M.

AU - Vrublevska, Jelena

AU - Vukovic, Olivera

AU - Vysotska, Olga

AU - Widiasih, Natalia

AU - Yashikhina, Anna

AU - Prezerakos, Panagiotis E.

AU - Smirnova, Daria

PY - 2024/4

Y1 - 2024/4

N2 - Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.Methods The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions.Results About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome.Conclusions The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.

AB - Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.Methods The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions.Results About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome.Conclusions The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.

KW - Epidemiology

KW - Disability

KW - Multicomorbidity

KW - Premature death

KW - Somatic-mental comorbidity

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=wosstart_imp_pure20230417&SrcAuth=WosAPI&KeyUT=WOS:001164582600001&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1017/S1092852924000026

DO - 10.1017/S1092852924000026

M3 - Article

C2 - 38269574

SN - 1092-8529

VL - 29

SP - 126

EP - 149

JO - CNS Spectrums

JF - CNS Spectrums

IS - 2

ER -

Fountoulakis KN, Karakatsoulis GN, Abraham S, Adorjan K, Ahmed HU, Alarcon RD et al. Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study). CNS Spectrums. 2024 Apr;29(2):126-149. Epub 2024 Jan. doi: 10.1017/S1092852924000026

Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)

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