Stressful life events and incident metabolic syndrome

The Hoorn study

F. Rutters, S. Pilz, A.D. Koopman, S.P. Rauh, F. Pouwer, C.D. Stehouwer, P.J. Elders, G. Nijpels, J.M. Dekker

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Stressful life events are associated with the metabolic syndrome in cross-sectional studies, but prospective studies addressing this issue are rare and limited. We therefore evaluated whether the number of stressful life events is associated with incident metabolic syndrome. We assessed the association between the number of stressful life events experienced in the 5 years up until baseline and incident metabolic syndrome after 6.5 years at follow-up in the Hoorn study, a middle-aged and elderly population-based cohort. Participants with prevalent metabolic syndrome at baseline were excluded. Metabolic syndrome was defined according to the Adult Treatment Panel III, including fasting plasma glucose levels, HDL-C levels, triglyceride levels, waist circumference and hypertension. We included 1099 participants (47% male; age 60 ± 7 years). During 6.5 years of follow-up, 238 participants (22%) developed the metabolic syndrome. Logistic regression adjusted for age, sex, education level and follow-up duration showed a positive association between the number of stressful life events at baseline and incident metabolic syndrome [OR 1.13 (1.01–1.27) per event, p = 0.049]. In addition, a Poisson model showed a significant positive association between the number of stressful life events at baseline and the number of metabolic syndrome factors at follow-up [OR 1.05 (1.01–1.11) per event, p = 0.018]. Finally, we observed a significant association between the number of stressful life events at baseline and waist circumference at follow-up [adjusted for confounders β 0.86 (0.39–1.34) cm per event, p < 0.001]. Overall, we concluded that persons who reported more stressful life events at baseline had a significantly increased risk for developing metabolic syndrome during 6.5 years of follow-up, in a middle-aged and elderly population-based cohort. Keywords: Incident, metabolic syndrome, stressful life events, waist circumference
Original languageEnglish
Pages (from-to)507-513
JournalStress
Volume18
Issue number5
DOIs
Publication statusPublished - 2015

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Fasting
Cross-Sectional Studies
Logistic Models

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Rutters, F., Pilz, S., Koopman, A. D., Rauh, S. P., Pouwer, F., Stehouwer, C. D., ... Dekker, J. M. (2015). Stressful life events and incident metabolic syndrome: The Hoorn study. Stress, 18(5), 507-513. https://doi.org/10.3109/10253890.2015.1064891
Rutters, F. ; Pilz, S. ; Koopman, A.D. ; Rauh, S.P. ; Pouwer, F. ; Stehouwer, C.D. ; Elders, P.J. ; Nijpels, G. ; Dekker, J.M. / Stressful life events and incident metabolic syndrome : The Hoorn study. In: Stress. 2015 ; Vol. 18, No. 5. pp. 507-513.
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title = "Stressful life events and incident metabolic syndrome: The Hoorn study",
abstract = "Stressful life events are associated with the metabolic syndrome in cross-sectional studies, but prospective studies addressing this issue are rare and limited. We therefore evaluated whether the number of stressful life events is associated with incident metabolic syndrome. We assessed the association between the number of stressful life events experienced in the 5 years up until baseline and incident metabolic syndrome after 6.5 years at follow-up in the Hoorn study, a middle-aged and elderly population-based cohort. Participants with prevalent metabolic syndrome at baseline were excluded. Metabolic syndrome was defined according to the Adult Treatment Panel III, including fasting plasma glucose levels, HDL-C levels, triglyceride levels, waist circumference and hypertension. We included 1099 participants (47{\%} male; age 60 ± 7 years). During 6.5 years of follow-up, 238 participants (22{\%}) developed the metabolic syndrome. Logistic regression adjusted for age, sex, education level and follow-up duration showed a positive association between the number of stressful life events at baseline and incident metabolic syndrome [OR 1.13 (1.01–1.27) per event, p = 0.049]. In addition, a Poisson model showed a significant positive association between the number of stressful life events at baseline and the number of metabolic syndrome factors at follow-up [OR 1.05 (1.01–1.11) per event, p = 0.018]. Finally, we observed a significant association between the number of stressful life events at baseline and waist circumference at follow-up [adjusted for confounders β 0.86 (0.39–1.34) cm per event, p < 0.001]. Overall, we concluded that persons who reported more stressful life events at baseline had a significantly increased risk for developing metabolic syndrome during 6.5 years of follow-up, in a middle-aged and elderly population-based cohort. Keywords: Incident, metabolic syndrome, stressful life events, waist circumference",
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Rutters, F, Pilz, S, Koopman, AD, Rauh, SP, Pouwer, F, Stehouwer, CD, Elders, PJ, Nijpels, G & Dekker, JM 2015, 'Stressful life events and incident metabolic syndrome: The Hoorn study', Stress, vol. 18, no. 5, pp. 507-513. https://doi.org/10.3109/10253890.2015.1064891

Stressful life events and incident metabolic syndrome : The Hoorn study. / Rutters, F.; Pilz, S.; Koopman, A.D.; Rauh, S.P.; Pouwer, F.; Stehouwer, C.D.; Elders, P.J.; Nijpels, G.; Dekker, J.M.

In: Stress, Vol. 18, No. 5, 2015, p. 507-513.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Stressful life events and incident metabolic syndrome

T2 - The Hoorn study

AU - Rutters, F.

AU - Pilz, S.

AU - Koopman, A.D.

AU - Rauh, S.P.

AU - Pouwer, F.

AU - Stehouwer, C.D.

AU - Elders, P.J.

AU - Nijpels, G.

AU - Dekker, J.M.

PY - 2015

Y1 - 2015

N2 - Stressful life events are associated with the metabolic syndrome in cross-sectional studies, but prospective studies addressing this issue are rare and limited. We therefore evaluated whether the number of stressful life events is associated with incident metabolic syndrome. We assessed the association between the number of stressful life events experienced in the 5 years up until baseline and incident metabolic syndrome after 6.5 years at follow-up in the Hoorn study, a middle-aged and elderly population-based cohort. Participants with prevalent metabolic syndrome at baseline were excluded. Metabolic syndrome was defined according to the Adult Treatment Panel III, including fasting plasma glucose levels, HDL-C levels, triglyceride levels, waist circumference and hypertension. We included 1099 participants (47% male; age 60 ± 7 years). During 6.5 years of follow-up, 238 participants (22%) developed the metabolic syndrome. Logistic regression adjusted for age, sex, education level and follow-up duration showed a positive association between the number of stressful life events at baseline and incident metabolic syndrome [OR 1.13 (1.01–1.27) per event, p = 0.049]. In addition, a Poisson model showed a significant positive association between the number of stressful life events at baseline and the number of metabolic syndrome factors at follow-up [OR 1.05 (1.01–1.11) per event, p = 0.018]. Finally, we observed a significant association between the number of stressful life events at baseline and waist circumference at follow-up [adjusted for confounders β 0.86 (0.39–1.34) cm per event, p < 0.001]. Overall, we concluded that persons who reported more stressful life events at baseline had a significantly increased risk for developing metabolic syndrome during 6.5 years of follow-up, in a middle-aged and elderly population-based cohort. Keywords: Incident, metabolic syndrome, stressful life events, waist circumference

AB - Stressful life events are associated with the metabolic syndrome in cross-sectional studies, but prospective studies addressing this issue are rare and limited. We therefore evaluated whether the number of stressful life events is associated with incident metabolic syndrome. We assessed the association between the number of stressful life events experienced in the 5 years up until baseline and incident metabolic syndrome after 6.5 years at follow-up in the Hoorn study, a middle-aged and elderly population-based cohort. Participants with prevalent metabolic syndrome at baseline were excluded. Metabolic syndrome was defined according to the Adult Treatment Panel III, including fasting plasma glucose levels, HDL-C levels, triglyceride levels, waist circumference and hypertension. We included 1099 participants (47% male; age 60 ± 7 years). During 6.5 years of follow-up, 238 participants (22%) developed the metabolic syndrome. Logistic regression adjusted for age, sex, education level and follow-up duration showed a positive association between the number of stressful life events at baseline and incident metabolic syndrome [OR 1.13 (1.01–1.27) per event, p = 0.049]. In addition, a Poisson model showed a significant positive association between the number of stressful life events at baseline and the number of metabolic syndrome factors at follow-up [OR 1.05 (1.01–1.11) per event, p = 0.018]. Finally, we observed a significant association between the number of stressful life events at baseline and waist circumference at follow-up [adjusted for confounders β 0.86 (0.39–1.34) cm per event, p < 0.001]. Overall, we concluded that persons who reported more stressful life events at baseline had a significantly increased risk for developing metabolic syndrome during 6.5 years of follow-up, in a middle-aged and elderly population-based cohort. Keywords: Incident, metabolic syndrome, stressful life events, waist circumference

U2 - 10.3109/10253890.2015.1064891

DO - 10.3109/10253890.2015.1064891

M3 - Article

VL - 18

SP - 507

EP - 513

JO - Stress

JF - Stress

SN - 1025-3890

IS - 5

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Rutters F, Pilz S, Koopman AD, Rauh SP, Pouwer F, Stehouwer CD et al. Stressful life events and incident metabolic syndrome: The Hoorn study. Stress. 2015;18(5):507-513. https://doi.org/10.3109/10253890.2015.1064891