Study protocol for a randomized controlled trial evaluating the efficacy of an evidence-based iPad-app for cognitive rehabilitation in patients with primary brain tumors

S.D. van der Linden*, M.M. Sitskoorn, G.J.M. Rutten, K. Gehring

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Background:
Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started.
Objective:
To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease.
Methods:
Prior to surgery, patients with presumed low-grade glioma and meningioma are included. Before surgery and 3 mo after surgery, neuropsychological assessments are conducted. After the second neuropsychological assessment, patients are assigned to the intervention group or waiting-list control group. The intervention consists of psychoeducation,
compensation training, and retraining. Patients are advised to spend 3 h per
week on the program for 10 wk. Immediately after completion of the program and a halfyear thereafter, postintervention assessments take place. Patients in the control group are offered the opportunity to follow the program after all study assessments.
Expected outcomes:
We expect that early cognitive rehabilitation has beneficial effects on cognitive performance and PROMs in brain tumor patients.
Discussion:
The iPad-based program allows brain tumor patients to follow a cognitive rehabilitation program from their homes. Forthcoming results may contribute to further improvement of supportive care for brain tumor patients.
Original languageEnglish
Pages (from-to)273-279
JournalNeurosurgery
Volume85
Issue number2
DOIs
Publication statusPublished - 2019

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Waiting Lists
Feasibility Studies
Meningioma
Glioma

Keywords

  • Cognitive rehabilitation
  • E-Health
  • Intervention studies
  • Study protocol
  • Brain neoplasms
  • EHealth
  • RELIABILITY
  • INTERVENTIONS
  • Glioma
  • COMMUNITY
  • DEFICITS
  • QUESTIONNAIRE
  • Meningioma

Cite this

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title = "Study protocol for a randomized controlled trial evaluating the efficacy of an evidence-based iPad-app for cognitive rehabilitation in patients with primary brain tumors",
abstract = "Background: Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started.Objective: To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease.Methods: Prior to surgery, patients with presumed low-grade glioma and meningioma are included. Before surgery and 3 mo after surgery, neuropsychological assessments are conducted. After the second neuropsychological assessment, patients are assigned to the intervention group or waiting-list control group. The intervention consists of psychoeducation,compensation training, and retraining. Patients are advised to spend 3 h perweek on the program for 10 wk. Immediately after completion of the program and a halfyear thereafter, postintervention assessments take place. Patients in the control group are offered the opportunity to follow the program after all study assessments.Expected outcomes: We expect that early cognitive rehabilitation has beneficial effects on cognitive performance and PROMs in brain tumor patients.Discussion: The iPad-based program allows brain tumor patients to follow a cognitive rehabilitation program from their homes. Forthcoming results may contribute to further improvement of supportive care for brain tumor patients.",
keywords = "Cognitive rehabilitation, E-Health, Intervention studies, Study protocol, Brain neoplasms, EHealth, RELIABILITY, INTERVENTIONS, Glioma, COMMUNITY, DEFICITS, QUESTIONNAIRE, Meningioma",
author = "{van der Linden}, S.D. and M.M. Sitskoorn and G.J.M. Rutten and K. Gehring",
year = "2019",
doi = "10.1093/neuros/nyy254",
language = "English",
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pages = "273--279",
journal = "Neurosurgery",
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publisher = "Lippincott Williams and Wilkins",
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}

TY - JOUR

T1 - Study protocol for a randomized controlled trial evaluating the efficacy of an evidence-based iPad-app for cognitive rehabilitation in patients with primary brain tumors

AU - van der Linden, S.D.

AU - Sitskoorn, M.M.

AU - Rutten, G.J.M.

AU - Gehring, K.

PY - 2019

Y1 - 2019

N2 - Background: Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started.Objective: To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease.Methods: Prior to surgery, patients with presumed low-grade glioma and meningioma are included. Before surgery and 3 mo after surgery, neuropsychological assessments are conducted. After the second neuropsychological assessment, patients are assigned to the intervention group or waiting-list control group. The intervention consists of psychoeducation,compensation training, and retraining. Patients are advised to spend 3 h perweek on the program for 10 wk. Immediately after completion of the program and a halfyear thereafter, postintervention assessments take place. Patients in the control group are offered the opportunity to follow the program after all study assessments.Expected outcomes: We expect that early cognitive rehabilitation has beneficial effects on cognitive performance and PROMs in brain tumor patients.Discussion: The iPad-based program allows brain tumor patients to follow a cognitive rehabilitation program from their homes. Forthcoming results may contribute to further improvement of supportive care for brain tumor patients.

AB - Background: Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started.Objective: To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease.Methods: Prior to surgery, patients with presumed low-grade glioma and meningioma are included. Before surgery and 3 mo after surgery, neuropsychological assessments are conducted. After the second neuropsychological assessment, patients are assigned to the intervention group or waiting-list control group. The intervention consists of psychoeducation,compensation training, and retraining. Patients are advised to spend 3 h perweek on the program for 10 wk. Immediately after completion of the program and a halfyear thereafter, postintervention assessments take place. Patients in the control group are offered the opportunity to follow the program after all study assessments.Expected outcomes: We expect that early cognitive rehabilitation has beneficial effects on cognitive performance and PROMs in brain tumor patients.Discussion: The iPad-based program allows brain tumor patients to follow a cognitive rehabilitation program from their homes. Forthcoming results may contribute to further improvement of supportive care for brain tumor patients.

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KW - Intervention studies

KW - Study protocol

KW - Brain neoplasms

KW - EHealth

KW - RELIABILITY

KW - INTERVENTIONS

KW - Glioma

KW - COMMUNITY

KW - DEFICITS

KW - QUESTIONNAIRE

KW - Meningioma

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SN - 0148-396X

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