Task-evoked reconfiguration of the fronto-parietal network is associated with cognitive performance in brain tumor patients

Wouter De Baene*, Irena Schouwenaars, Martijn Jansma, Geert-Jan Rutten, Margriet Sitskoorn

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

In healthy participants, the strength of task-evoked network reconfigurations is associated with cognitive performance across several cognitive domains. It is, however, unclear whether the capacity for network reconfiguration also plays a role in cognitive deficits in brain tumor patients.
In the current study, we examined whether the level of reconfiguration of the fronto-parietal (‘FPN’) and default mode network (‘DMN’) during task execution is correlated with cognitive performance in patients with different types of brain tumors. For this purpose, we combined data from a resting state and task-fMRI paradigm in patients with a glioma or meningioma. Cognitive performance was measured using the in-scanner working memory task, as well as an out-of-scanner cognitive flexibility task.
Task-evoked changes in functional connectivity strength (defined as the mean of the absolute values of all connections) and in functional connectivity patterns within and between the FPN and DMN did not differ significantly across meningioma and fast (HGG) and slowly growing glioma (LGG) patients. Across these brain tumor patients, a significant and positive correlation was found between the level of task-evoked reconfiguration of the FPN and cognitive performance. This suggests that the capacity for FPN reconfiguration also plays a role in cognitive deficits in brain tumor patients, as was previously found for normal cognitive performance in healthy controls.
Original languageEnglish
Pages (from-to)2351-2366
JournalBrain Imaging and Behavior
Volume14
Issue number6
DOIs
Publication statusPublished - 2020

Keywords

  • Brain tumor patients
  • Cognitive flexibility
  • DEFAULT-MODE NETWORK
  • DEFICITS
  • DYNAMICS
  • FMRI
  • FUNCTIONAL CONNECTIVITY
  • Fronto-parietal network
  • INTERVENTIONS
  • LOW-GRADE GLIOMAS
  • MENINGIOMA PATIENTS
  • SURGERY
  • Task-evoked network reconfiguration
  • WORKING-MEMORY
  • Working memory

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