Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease

Gillian Coughlan; Vaisakh Puthusseryppady; Ellen Lowry; Rachel Gillings; Hugo Spiers; Anne-Marie Minihane; Michael Hornberger

doi:10.1371/journal.pone.0239077

Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease

Gillian Coughlan, Vaisakh Puthusseryppady, Ellen Lowry, Rachel Gillings, Hugo Spiers, Anne-Marie Minihane, Michael Hornberger

Cognitive Neuropsychology

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test-retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

Original language	English
Pages (from-to)	e0239077
Journal	PLOS ONE
Volume	15
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0239077
Publication status	Published - 2020

Keywords

Aged
Alzheimer Disease/diagnosis
Cognition
Female
Genetic Predisposition to Disease
Humans
Male
Memory, Episodic
Middle Aged
Neuropsychological Tests
Risk Factors
Sex Factors
Spatial Navigation

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title = "Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease",

abstract = "The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test-retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.",

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AU - Coughlan, Gillian

AU - Puthusseryppady, Vaisakh

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AU - Spiers, Hugo

AU - Minihane, Anne-Marie

AU - Hornberger, Michael

PY - 2020

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N2 - The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test-retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

AB - The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test-retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

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KW - Male

KW - Memory, Episodic

KW - Middle Aged

KW - Neuropsychological Tests

KW - Risk Factors

KW - Sex Factors

KW - Spatial Navigation

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SP - e0239077

JO - PLOS ONE

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ER -

Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease

Abstract

Keywords

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