The association of depressive symptoms, personality traits, and sociodemographic factors with health-related quality of life and quality of life in patients with advanced-stage lung cancer: An observational multi-center cohort study

M. de Mol, S. Visser, J. Aerts, P. Lodder, N.C. Van Walree, H. Belderbos, B.L. den Oudsten*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Background
Identification of patient-related factors associated with Health-Related Quality of Life (HRQoL) and Quality of Life (QoL) at the start of treatment may identify patients who are prone to a decrease in HRQoL and/or QoL resulting from chemotherapy. Identification of these factors may offer opportunities to enhance patient care during treatment by adapting communication strategies and directing medical and psychological interventions. The aim was to examine the association of sociodemographic factors, personality traits, and depressive symptoms with HRQoL and QoL in patients with advanced-stage lung cancer at the start of chemotherapy. 
Methods
Patients (n=151) completed the State-Trait Anxiety Inventory (trait anxiety subscale), the NeuroticismExtraversion-Openness-Five Factor Inventory (NEO-FFI), the Center for Epidemiologic Studies Depression (CES-D), the World Health Organization Quality of Life-BREF (WHOQOL-BREF), and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Simple linear regression analyses were performed to select HRQoL and QoL associated factors (a P≤0.10 was used to prevent non-identification of important factors) followed by multiple linear regression analyses (P≤0.05). 
Results
In the multiple regression analyses, CES-D score (β=−0.63 to −0.53; P-values <0.001) was most often associated with the WHOQOL-BREF domains and general facet, whereas CES-D score (β=−0.67 to −0.40; P-values <0.001) and Eastern Cooperative Oncology Group (ECOG) performance status (β=−0.30 to −0.30; P-values <0.001) were most often associated with the scales of the EORTC QLQ-C30. Personality traits were not related with HRQoL or QoL except for trait anxiety (Role functioning: β=0.30; P=0.02, Environment: β=−0.39; P=0.007) and conscientiousness (Physical health: β=0.20; P-value <0.04). 
Conclusions
Higher scores on depressive symptoms and ECOG performance status were related to lower HRQoL and QoL in patients with advanced-stage non-small cell lung cancer. Supportive care interventions aimed at improvement of depressive symptoms and performance score may facilitate an increase of HRQoL and/or QoL during treatment.
Original languageEnglish
Article number431
Number of pages14
JournalBMC Cancer
Volume20
Issue number431
DOIs
Publication statusPublished - 2020

Keywords

  • ANXIETY
  • BREAST-CANCER
  • CARE
  • Cancer
  • Depression
  • EUROPEAN-ORGANIZATION
  • IMPACT
  • Lung neoplasms
  • Oncology
  • Personality traits
  • QLQ-C30
  • Quality of life
  • SCALE
  • SELF

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