The burden of acute lymphoid leukemia among adolescents and young adults in the Western Pacific Region: Evidence from Global Burden Disease 2019

F. Yang, B. Zhang, P. Lodder, J. Guo*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Purpose
Acute lymphoblastic leukemia (ALL) is a type of blood cancer that affects white blood cells. Here, we use data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, to estimate the burden and incidence rate changes in adolescents and young adults (AYA) ALL in the Western Pacific Region and to reveal potential risk factors of incidence- and mortality rates.

Methods
The GBD 2019 study data was stratified by sex, age, country, and territory. We calculated the Estimated annual percentage changes (estimated APC) in mortality and incidence rates for each of the 25 countries and territories of the western Pacific region from 1990 to 2019.

Results
This study found global AYA ALL incidence rates had increased while the mortality rates had decreased between 1990 and 2019. Moreover, healthcare access and quality (HAQ), and government per capita health spending were identified as country-level risk factors of AYA ALL incidence rates, while HAQ, male education, and sex were identified as mortality rate predictors in 25 Western Pacific Region countries.

Conclusion
To address and reduce the burden of incidence and mortality among AYA, various regions around the world, particularly developing countries, could revise their AYA prevention and treatment strategies.
Original languageEnglish
Pages (from-to)839-848
Number of pages10
JournalCancer Causes & Control
Volume35
Issue number5
DOIs
Publication statusPublished - 2024

Keywords

  • Acute lymphoid leukemia
  • Adolescents and young adults
  • Incidence rate
  • Mortality rate
  • Western Pacific region

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