The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients

C.S. Bonhof*, L.V. van de Poll-Franse, D.K. Wasowicz, L.V. Beerepoot, G. Vreugdenhil, F. Mols

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Purpose: 

To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. 

Methods: 

All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results: Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. 

Conclusions:

Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. 

Implications for cancer survivors: 

Patients need to be informed of both CIPN and the impact on HRQoL.

Original languageEnglish
Number of pages11
JournalJournal of Cancer Survivorship
DOIs
Publication statusE-pub ahead of print - 2021

Keywords

  • CHEMOTHERAPY
  • Colorectal cancer
  • Health-related quality of life
  • OXALIPLATIN
  • PROFILES
  • Peripheral neuropathy
  • QUESTIONNAIRE
  • SURVIVORS

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