The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy

Mark de Mol, B.L. den Oudsten, Mieke Aarts, Joachim G J V Aerts

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Abstract

Background:

Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy.

Methods:

Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study.

Results:

In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was.

Conclusions:

In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue.

Original languageEnglish
Pages (from-to)36743-36749
JournalOncotarget
Volume8
DOIs
Publication statusPublished - 2017

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Carboplatin
Comorbidity

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@article{e1b838caaa4c498e83bbbdda6366847e,
title = "The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy",
abstract = "Background: Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy.Methods: Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study.Results: In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was.Conclusions: In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue.",
author = "{de Mol}, Mark and {den Oudsten}, B.L. and Mieke Aarts and Aerts, {Joachim G J V}",
year = "2017",
doi = "10.18632/oncotarget.14151",
language = "English",
volume = "8",
pages = "36743--36749",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",

}

The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy. / de Mol, Mark; den Oudsten, B.L.; Aarts, Mieke; Aerts, Joachim G J V.

In: Oncotarget, Vol. 8, 2017, p. 36743-36749.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy

AU - de Mol, Mark

AU - den Oudsten, B.L.

AU - Aarts, Mieke

AU - Aerts, Joachim G J V

PY - 2017

Y1 - 2017

N2 - Background: Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy.Methods: Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study.Results: In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was.Conclusions: In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue.

AB - Background: Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy.Methods: Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study.Results: In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was.Conclusions: In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue.

U2 - 10.18632/oncotarget.14151

DO - 10.18632/oncotarget.14151

M3 - Article

VL - 8

SP - 36743

EP - 36749

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

ER -