The effect of exercise on cancer-related fatigue in cancer survivors

A systematic review and meta-analysis

E. Kessels, O. Husson, C.M. van der Feltz-Cornelis

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Objective:
The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls.
Methods:
Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care. We evaluated risk of bias of individual trials following Cochrane Quality criteria. We performed a random-effects meta-analysis in the low risk of bias trials with intervention type, exercise intensity, adherence, and cancer type as moderators, and also performed meta-regression analyses and a sensitivity analysis including the high risk of bias trials.
Results:
Out of 274 trials, 11 met the inclusion criteria, of which six had low risk of bias. Exercise improved CRF with large effect size (Cohen’s d 0.605, 95% CI 0.235–0.975) with no significant difference between types of cancer. Aerobic exercise (Δ=1.009, CI 0.222–1.797) showed a significantly greater effect than a combination of aerobic and resistance exercises (Δ=0.341, CI 0.129–0.552). Moderator and meta-regression analyses showed high adherence yielding best improvements.
Conclusion:
Exercise has a large effect on CRF in cancer survivors. Aerobic interventions with high adherence have the best result.
Original languageEnglish
Pages (from-to)479-494
JournalNeuropsychiatric Disease and Treatment
Volume14
DOIs
Publication statusPublished - 2018

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Neoplasms
Exercise
Palliative Care
PubMed
Self Report
Databases

Keywords

  • BEHAVIOR
  • BREAST-CANCER
  • CHEMOTHERAPY
  • INTERVENTION
  • PACE TRIAL
  • PREVALENCE
  • QUALITY-OF-LIFE
  • RANDOMIZED CONTROLLED-TRIAL
  • WALKING PROGRAM
  • WOMEN
  • cancer survivors
  • cancer-related fatigue
  • exercise
  • meta analysis
  • randomized clinical trials
  • systematic review

Cite this

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title = "The effect of exercise on cancer-related fatigue in cancer survivors: A systematic review and meta-analysis",
abstract = "Objective: The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls.Methods: Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care. We evaluated risk of bias of individual trials following Cochrane Quality criteria. We performed a random-effects meta-analysis in the low risk of bias trials with intervention type, exercise intensity, adherence, and cancer type as moderators, and also performed meta-regression analyses and a sensitivity analysis including the high risk of bias trials.Results: Out of 274 trials, 11 met the inclusion criteria, of which six had low risk of bias. Exercise improved CRF with large effect size (Cohen’s d 0.605, 95{\%} CI 0.235–0.975) with no significant difference between types of cancer. Aerobic exercise (Δ=1.009, CI 0.222–1.797) showed a significantly greater effect than a combination of aerobic and resistance exercises (Δ=0.341, CI 0.129–0.552). Moderator and meta-regression analyses showed high adherence yielding best improvements.Conclusion: Exercise has a large effect on CRF in cancer survivors. Aerobic interventions with high adherence have the best result.",
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author = "E. Kessels and O. Husson and {van der Feltz-Cornelis}, C.M.",
year = "2018",
doi = "10.2147/NDT.S150464",
language = "English",
volume = "14",
pages = "479--494",
journal = "Neuropsychiatric Disease and Treatment",
issn = "1176-6328",
publisher = "Dove Medical Press Ltd.",

}

The effect of exercise on cancer-related fatigue in cancer survivors : A systematic review and meta-analysis. / Kessels, E.; Husson, O.; van der Feltz-Cornelis, C.M.

In: Neuropsychiatric Disease and Treatment, Vol. 14, 2018, p. 479-494.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The effect of exercise on cancer-related fatigue in cancer survivors

T2 - A systematic review and meta-analysis

AU - Kessels, E.

AU - Husson, O.

AU - van der Feltz-Cornelis, C.M.

PY - 2018

Y1 - 2018

N2 - Objective: The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls.Methods: Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care. We evaluated risk of bias of individual trials following Cochrane Quality criteria. We performed a random-effects meta-analysis in the low risk of bias trials with intervention type, exercise intensity, adherence, and cancer type as moderators, and also performed meta-regression analyses and a sensitivity analysis including the high risk of bias trials.Results: Out of 274 trials, 11 met the inclusion criteria, of which six had low risk of bias. Exercise improved CRF with large effect size (Cohen’s d 0.605, 95% CI 0.235–0.975) with no significant difference between types of cancer. Aerobic exercise (Δ=1.009, CI 0.222–1.797) showed a significantly greater effect than a combination of aerobic and resistance exercises (Δ=0.341, CI 0.129–0.552). Moderator and meta-regression analyses showed high adherence yielding best improvements.Conclusion: Exercise has a large effect on CRF in cancer survivors. Aerobic interventions with high adherence have the best result.

AB - Objective: The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls.Methods: Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care. We evaluated risk of bias of individual trials following Cochrane Quality criteria. We performed a random-effects meta-analysis in the low risk of bias trials with intervention type, exercise intensity, adherence, and cancer type as moderators, and also performed meta-regression analyses and a sensitivity analysis including the high risk of bias trials.Results: Out of 274 trials, 11 met the inclusion criteria, of which six had low risk of bias. Exercise improved CRF with large effect size (Cohen’s d 0.605, 95% CI 0.235–0.975) with no significant difference between types of cancer. Aerobic exercise (Δ=1.009, CI 0.222–1.797) showed a significantly greater effect than a combination of aerobic and resistance exercises (Δ=0.341, CI 0.129–0.552). Moderator and meta-regression analyses showed high adherence yielding best improvements.Conclusion: Exercise has a large effect on CRF in cancer survivors. Aerobic interventions with high adherence have the best result.

KW - BEHAVIOR

KW - BREAST-CANCER

KW - CHEMOTHERAPY

KW - INTERVENTION

KW - PACE TRIAL

KW - PREVALENCE

KW - QUALITY-OF-LIFE

KW - RANDOMIZED CONTROLLED-TRIAL

KW - WALKING PROGRAM

KW - WOMEN

KW - cancer survivors

KW - cancer-related fatigue

KW - exercise

KW - meta analysis

KW - randomized clinical trials

KW - systematic review

U2 - 10.2147/NDT.S150464

DO - 10.2147/NDT.S150464

M3 - Article

VL - 14

SP - 479

EP - 494

JO - Neuropsychiatric Disease and Treatment

JF - Neuropsychiatric Disease and Treatment

SN - 1176-6328

ER -