The Encoding/Retrieval Flip: Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks

Willem Huijbers*, Aaron P. Schultz, Patrizia Vannini, Donald G. McLaren, Sarah E. Wigman, Andrew M. Ward, Trey Hedden, Reisa A. Sperling

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

fMRI studies have linked the posteromedial cortex to episodic learning (encoding) and remembering (retrieval) processes. The posteromedial cortex is considered part of the default network and tends to deactivate during encoding but activate during retrieval, a pattern known as the encoding/retrieval flip. Yet, the exact relationship between the neural correlates of memory performance (hit/miss) and memory stage (encoding/retrieval) and the extent of overlap with intrinsic cortical networks remains to be elucidated. Using task-based fMRI, we isolated the pattern of activity associated with memory performance, memory stage, and the interaction between both. Using resting-state fMRI, we identified which intrinsic large-scale functional networks overlapped with regions showing task-induced effects. Our results demonstrated an effect of successful memory performance in regions associated with the control network and an effect of unsuccessful memory performance in the ventral attention network. We found an effect of memory retrieval in brain regions that span the default and control networks. Finally, we found an interaction between memory performance and memory stage in brain regions associated with the default network, including the posteromedial cortex, posterior parietal cortex, and parahippocampal cortex. We discuss these findings in relation to the encoding/retrieval flip. In general, the findings demonstrate that task-induced effects cut across intrinsic cortical networks. Furthermore, regions within the default network display functional dissociations, and this may have implications for the neural underpinnings of age-related memory disorders.

Original languageEnglish
Pages (from-to)1163-1179
Number of pages17
JournalJournal of Cognitive Neuroscience
Volume25
Issue number7
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Keywords

  • POSTERIOR CINGULATE CORTEX
  • RESTING HUMAN BRAIN
  • EVENT-RELATED FMRI
  • FUNCTIONAL CONNECTIVITY
  • PARIETAL CORTEX
  • ALZHEIMERS-DISEASE
  • DEFAULT NETWORK
  • EXECUTIVE FUNCTIONS
  • SUBSEQUENT MEMORY
  • COGNITIVE CONTROL

Cite this

Huijbers, W., Schultz, A. P., Vannini, P., McLaren, D. G., Wigman, S. E., Ward, A. M., ... Sperling, R. A. (2013). The Encoding/Retrieval Flip: Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks. Journal of Cognitive Neuroscience, 25(7), 1163-1179. https://doi.org/10.1162/jocn_a_00366
Huijbers, Willem ; Schultz, Aaron P. ; Vannini, Patrizia ; McLaren, Donald G. ; Wigman, Sarah E. ; Ward, Andrew M. ; Hedden, Trey ; Sperling, Reisa A. / The Encoding/Retrieval Flip : Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks. In: Journal of Cognitive Neuroscience. 2013 ; Vol. 25, No. 7. pp. 1163-1179.
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abstract = "fMRI studies have linked the posteromedial cortex to episodic learning (encoding) and remembering (retrieval) processes. The posteromedial cortex is considered part of the default network and tends to deactivate during encoding but activate during retrieval, a pattern known as the encoding/retrieval flip. Yet, the exact relationship between the neural correlates of memory performance (hit/miss) and memory stage (encoding/retrieval) and the extent of overlap with intrinsic cortical networks remains to be elucidated. Using task-based fMRI, we isolated the pattern of activity associated with memory performance, memory stage, and the interaction between both. Using resting-state fMRI, we identified which intrinsic large-scale functional networks overlapped with regions showing task-induced effects. Our results demonstrated an effect of successful memory performance in regions associated with the control network and an effect of unsuccessful memory performance in the ventral attention network. We found an effect of memory retrieval in brain regions that span the default and control networks. Finally, we found an interaction between memory performance and memory stage in brain regions associated with the default network, including the posteromedial cortex, posterior parietal cortex, and parahippocampal cortex. We discuss these findings in relation to the encoding/retrieval flip. In general, the findings demonstrate that task-induced effects cut across intrinsic cortical networks. Furthermore, regions within the default network display functional dissociations, and this may have implications for the neural underpinnings of age-related memory disorders.",
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author = "Willem Huijbers and Schultz, {Aaron P.} and Patrizia Vannini and McLaren, {Donald G.} and Wigman, {Sarah E.} and Ward, {Andrew M.} and Trey Hedden and Sperling, {Reisa A.}",
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Huijbers, W, Schultz, AP, Vannini, P, McLaren, DG, Wigman, SE, Ward, AM, Hedden, T & Sperling, RA 2013, 'The Encoding/Retrieval Flip: Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks', Journal of Cognitive Neuroscience, vol. 25, no. 7, pp. 1163-1179. https://doi.org/10.1162/jocn_a_00366

The Encoding/Retrieval Flip : Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks. / Huijbers, Willem; Schultz, Aaron P.; Vannini, Patrizia; McLaren, Donald G.; Wigman, Sarah E.; Ward, Andrew M.; Hedden, Trey; Sperling, Reisa A.

In: Journal of Cognitive Neuroscience, Vol. 25, No. 7, 07.2013, p. 1163-1179.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - The Encoding/Retrieval Flip

T2 - Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks

AU - Huijbers, Willem

AU - Schultz, Aaron P.

AU - Vannini, Patrizia

AU - McLaren, Donald G.

AU - Wigman, Sarah E.

AU - Ward, Andrew M.

AU - Hedden, Trey

AU - Sperling, Reisa A.

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N2 - fMRI studies have linked the posteromedial cortex to episodic learning (encoding) and remembering (retrieval) processes. The posteromedial cortex is considered part of the default network and tends to deactivate during encoding but activate during retrieval, a pattern known as the encoding/retrieval flip. Yet, the exact relationship between the neural correlates of memory performance (hit/miss) and memory stage (encoding/retrieval) and the extent of overlap with intrinsic cortical networks remains to be elucidated. Using task-based fMRI, we isolated the pattern of activity associated with memory performance, memory stage, and the interaction between both. Using resting-state fMRI, we identified which intrinsic large-scale functional networks overlapped with regions showing task-induced effects. Our results demonstrated an effect of successful memory performance in regions associated with the control network and an effect of unsuccessful memory performance in the ventral attention network. We found an effect of memory retrieval in brain regions that span the default and control networks. Finally, we found an interaction between memory performance and memory stage in brain regions associated with the default network, including the posteromedial cortex, posterior parietal cortex, and parahippocampal cortex. We discuss these findings in relation to the encoding/retrieval flip. In general, the findings demonstrate that task-induced effects cut across intrinsic cortical networks. Furthermore, regions within the default network display functional dissociations, and this may have implications for the neural underpinnings of age-related memory disorders.

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KW - RESTING HUMAN BRAIN

KW - EVENT-RELATED FMRI

KW - FUNCTIONAL CONNECTIVITY

KW - PARIETAL CORTEX

KW - ALZHEIMERS-DISEASE

KW - DEFAULT NETWORK

KW - EXECUTIVE FUNCTIONS

KW - SUBSEQUENT MEMORY

KW - COGNITIVE CONTROL

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DO - 10.1162/jocn_a_00366

M3 - Article

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EP - 1179

JO - Journal of Cognitive Neuroscience

JF - Journal of Cognitive Neuroscience

SN - 0898-929X

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