The genetic basis of quality of life in healthy Swedish woman: A candidate gene approach

D. Schoormans, Jingmei Li, Hatef Darabi, Yvonne Brandberg, Mirjam Sprangers, Mikael Eriksson, Koos Zwinderman, Per Hall

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background
Quality of life (QoL) is an increasingly important parameter in clinical practice as it predicts mortality and poor health outcomes. It is hypothesized that one may have a genetic predisposition for QoL. We therefore related 139 candidate genes, selected through a literature search, to QoL in healthy females.
Methods
In 5,142 healthy females, background characteristics (i.e. demographic, clinical, lifestyle, and psychological factors) were assessed. QoL was measured by the EORTC QLQ-C30, which consists of 15 domains. For all women genotype information was available. For each candidate gene, single nucleotide polymorphisms (SNPs) were identified based on their functional (n = 2,663) and physical annotation (n = 10,649). SNPs were related to each QoL-domain, while controlling for background characteristics and population stratification. Finally, gene-based analyses were performed relating the combined effect of 10,649 SNPs (selected based on physical annotation) for each gene, to QoL using the statistical software package VEGAS.
Results
Overall, we found no relation between genetic variations (SNPs and genes) and 14 out of 15 QoL-domains. The strongest association was found between cognitive functioning and the top SNP rs1468951 (p = 1.21E-05) in the GSTZ1 gene. Furthermore, results of the gene-based test showed that the combined effect of 11 SNPs within the GSTZ1 gene is significantly associated with cognitive functioning (p = 2.60E-05).
Conclusion
If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the
Original languageEnglish
Article numbere0118292
JournalPLoS ONE
Volume10
Issue number2
DOIs
Publication statusPublished - 2015

Cite this

Schoormans, D., Li, J., Darabi, H., Brandberg, Y., Sprangers, M., Eriksson, M., ... Hall, P. (2015). The genetic basis of quality of life in healthy Swedish woman: A candidate gene approach. PLoS ONE, 10(2), [e0118292]. https://doi.org/10.1371/journal.pone.0118292
Schoormans, D. ; Li, Jingmei ; Darabi, Hatef ; Brandberg, Yvonne ; Sprangers, Mirjam ; Eriksson, Mikael ; Zwinderman, Koos ; Hall, Per. / The genetic basis of quality of life in healthy Swedish woman : A candidate gene approach. In: PLoS ONE. 2015 ; Vol. 10, No. 2.
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Schoormans, D, Li, J, Darabi, H, Brandberg, Y, Sprangers, M, Eriksson, M, Zwinderman, K & Hall, P 2015, 'The genetic basis of quality of life in healthy Swedish woman: A candidate gene approach' PLoS ONE, vol. 10, no. 2, e0118292. https://doi.org/10.1371/journal.pone.0118292

The genetic basis of quality of life in healthy Swedish woman : A candidate gene approach. / Schoormans, D.; Li, Jingmei; Darabi, Hatef; Brandberg, Yvonne; Sprangers, Mirjam; Eriksson, Mikael; Zwinderman, Koos; Hall, Per.

In: PLoS ONE, Vol. 10, No. 2, e0118292, 2015.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - The genetic basis of quality of life in healthy Swedish woman

T2 - A candidate gene approach

AU - Schoormans, D.

AU - Li, Jingmei

AU - Darabi, Hatef

AU - Brandberg, Yvonne

AU - Sprangers, Mirjam

AU - Eriksson, Mikael

AU - Zwinderman, Koos

AU - Hall, Per

PY - 2015

Y1 - 2015

N2 - BackgroundQuality of life (QoL) is an increasingly important parameter in clinical practice as it predicts mortality and poor health outcomes. It is hypothesized that one may have a genetic predisposition for QoL. We therefore related 139 candidate genes, selected through a literature search, to QoL in healthy females.MethodsIn 5,142 healthy females, background characteristics (i.e. demographic, clinical, lifestyle, and psychological factors) were assessed. QoL was measured by the EORTC QLQ-C30, which consists of 15 domains. For all women genotype information was available. For each candidate gene, single nucleotide polymorphisms (SNPs) were identified based on their functional (n = 2,663) and physical annotation (n = 10,649). SNPs were related to each QoL-domain, while controlling for background characteristics and population stratification. Finally, gene-based analyses were performed relating the combined effect of 10,649 SNPs (selected based on physical annotation) for each gene, to QoL using the statistical software package VEGAS.ResultsOverall, we found no relation between genetic variations (SNPs and genes) and 14 out of 15 QoL-domains. The strongest association was found between cognitive functioning and the top SNP rs1468951 (p = 1.21E-05) in the GSTZ1 gene. Furthermore, results of the gene-based test showed that the combined effect of 11 SNPs within the GSTZ1 gene is significantly associated with cognitive functioning (p = 2.60E-05).ConclusionIf validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the

AB - BackgroundQuality of life (QoL) is an increasingly important parameter in clinical practice as it predicts mortality and poor health outcomes. It is hypothesized that one may have a genetic predisposition for QoL. We therefore related 139 candidate genes, selected through a literature search, to QoL in healthy females.MethodsIn 5,142 healthy females, background characteristics (i.e. demographic, clinical, lifestyle, and psychological factors) were assessed. QoL was measured by the EORTC QLQ-C30, which consists of 15 domains. For all women genotype information was available. For each candidate gene, single nucleotide polymorphisms (SNPs) were identified based on their functional (n = 2,663) and physical annotation (n = 10,649). SNPs were related to each QoL-domain, while controlling for background characteristics and population stratification. Finally, gene-based analyses were performed relating the combined effect of 10,649 SNPs (selected based on physical annotation) for each gene, to QoL using the statistical software package VEGAS.ResultsOverall, we found no relation between genetic variations (SNPs and genes) and 14 out of 15 QoL-domains. The strongest association was found between cognitive functioning and the top SNP rs1468951 (p = 1.21E-05) in the GSTZ1 gene. Furthermore, results of the gene-based test showed that the combined effect of 11 SNPs within the GSTZ1 gene is significantly associated with cognitive functioning (p = 2.60E-05).ConclusionIf validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the

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