Abstract
Purpose
To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs of colorectal cancer (CRC) patients undergoing conventional surgery.
Methods
Data were extracted from the CAIRO6 trial (CRS-HIPEC group) and the PROCORE
study (conventional surgery group). Nine predefined PROs (derived from the EORTC QLQ-C30 questionnaire) were compared at baseline, in the early postoperative period and one year postoperatively, with correction for treatment with systemic therapy using linear mixed modeling.
Results
In total, 331 patients were included: 71 in the CRS-HIPEC group and 260 in the conventional surgery group. All predefined PROs (fatigue, diarrhea, C30 summary score, Global Health Status, physical, role, emotional, cognitive, and social functioning) did not differ significantly between the groups at all three timepoints, and differential effects over time for all PROs did not differ
significantly between the groups. Significant worsening of fatigue, C30 summary score, physical and role functioning (both groups), and cognitive and social functioning (conventional surgery group only) was present in the early postoperative period. All scores returned to baseline at one year postoperatively, except for physical and cognitive functioning in the conventional surgery
group. Emotional functioning improved postoperatively in both groups compared to baseline.
Conclusion
Despite a more extensive procedure with greater risk of morbidity, CRS-HIPEC in patients with colorectal peritoneal metastases did not have a greater negative impact on PROs than conventional surgery in patients with CRC. Further, systemic therapy did not affect these PROs. These findings may facilitate future patient counseling and shared decision making in clinical practice.
To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs of colorectal cancer (CRC) patients undergoing conventional surgery.
Methods
Data were extracted from the CAIRO6 trial (CRS-HIPEC group) and the PROCORE
study (conventional surgery group). Nine predefined PROs (derived from the EORTC QLQ-C30 questionnaire) were compared at baseline, in the early postoperative period and one year postoperatively, with correction for treatment with systemic therapy using linear mixed modeling.
Results
In total, 331 patients were included: 71 in the CRS-HIPEC group and 260 in the conventional surgery group. All predefined PROs (fatigue, diarrhea, C30 summary score, Global Health Status, physical, role, emotional, cognitive, and social functioning) did not differ significantly between the groups at all three timepoints, and differential effects over time for all PROs did not differ
significantly between the groups. Significant worsening of fatigue, C30 summary score, physical and role functioning (both groups), and cognitive and social functioning (conventional surgery group only) was present in the early postoperative period. All scores returned to baseline at one year postoperatively, except for physical and cognitive functioning in the conventional surgery
group. Emotional functioning improved postoperatively in both groups compared to baseline.
Conclusion
Despite a more extensive procedure with greater risk of morbidity, CRS-HIPEC in patients with colorectal peritoneal metastases did not have a greater negative impact on PROs than conventional surgery in patients with CRC. Further, systemic therapy did not affect these PROs. These findings may facilitate future patient counseling and shared decision making in clinical practice.
| Original language | English |
|---|---|
| Article number | 788 |
| Number of pages | 14 |
| Journal | Cancers |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2023 |
Keywords
- COLORECTAL-CANCER
- CRS-HIPEC
- METASTASES
- MORBIDITY
- PERITONEAL CARCINOMATOSIS
- PROGNOSTIC-FACTORS
- QLQ-C30
- QUALITY-OF-LIFE
- RANDOMIZED-TRIAL
- SYSTEMIC CHEMOTHERAPY
- THERAPY
- colorectal neoplasms
- cytoreduction
- patient-reported outcome measures
- peritoneal neoplasms
- quality of life
- surgical procedures
