The impact of having both cancer and diabetes on patient-reported outcomes: A systematic review and directions for future research

P.A.J. Vissers, L. Falzon, L.V. van de Poll-Franse, F. Pouwer, M.S.Y. Thong

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Abstract

Purpose
This systematic review aims to summarize the current literature regarding potential effects of having both cancer and diabetes on patient-reported outcomes (PROs) and to provide directions for future research.
Methods
MEDLINE, The Cochrane Library, CINAHL, and PsycINFO were searched from inception to January 2015. All English peer-reviewed studies that included patients with both cancer and diabetes and assessed PROs were included. All included studies were independently assessed on methodological quality by two investigators.
Results
Of the 3553 identified studies, 10 studies were included and all were considered of high (40 %) or adequate (60 %) methodological quality. Eight of the 10 studies focused on health-related quality of life (HRQoL), functioning, or symptoms and 2 studies assessed diabetes self-management. Overall, HRQoL and functioning was lower, and symptoms were higher among patients with both cancer and diabetes as compared to having cancer or diabetes alone. Furthermore, one study reported that diabetes self-management was impaired after chemotherapy.
Conclusions
Having both cancer and diabetes resulted in worse PROs compared to having either one of the diseases, however, the considerable heterogeneity of the included studies hampered strong conclusions. Future studies are needed as this research area is largely neglected. As the majority of the included studies focused on HRQoL, future research should address the impact of both diseases on other PROs such as depression, patient empowerment and self-management.
Implications for Cancer Survivor
Having both cancer and diabetes might result in worse PROs, however, more research is needed as current evidence is scarce.
Keywords
Cancer, Diabetes, Patient-reported outcomes, Systematic review, Health-related quality of life
Original languageEnglish
Pages (from-to)406-415
JournalJournal of Cancer Survivorship
Volume10
Issue number2
DOIs
Publication statusPublished - 2016

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title = "The impact of having both cancer and diabetes on patient-reported outcomes: A systematic review and directions for future research",
abstract = "PurposeThis systematic review aims to summarize the current literature regarding potential effects of having both cancer and diabetes on patient-reported outcomes (PROs) and to provide directions for future research.MethodsMEDLINE, The Cochrane Library, CINAHL, and PsycINFO were searched from inception to January 2015. All English peer-reviewed studies that included patients with both cancer and diabetes and assessed PROs were included. All included studies were independently assessed on methodological quality by two investigators.ResultsOf the 3553 identified studies, 10 studies were included and all were considered of high (40 {\%}) or adequate (60 {\%}) methodological quality. Eight of the 10 studies focused on health-related quality of life (HRQoL), functioning, or symptoms and 2 studies assessed diabetes self-management. Overall, HRQoL and functioning was lower, and symptoms were higher among patients with both cancer and diabetes as compared to having cancer or diabetes alone. Furthermore, one study reported that diabetes self-management was impaired after chemotherapy.ConclusionsHaving both cancer and diabetes resulted in worse PROs compared to having either one of the diseases, however, the considerable heterogeneity of the included studies hampered strong conclusions. Future studies are needed as this research area is largely neglected. As the majority of the included studies focused on HRQoL, future research should address the impact of both diseases on other PROs such as depression, patient empowerment and self-management.Implications for Cancer SurvivorHaving both cancer and diabetes might result in worse PROs, however, more research is needed as current evidence is scarce.KeywordsCancer, Diabetes, Patient-reported outcomes, Systematic review, Health-related quality of life",
author = "P.A.J. Vissers and L. Falzon and {van de Poll-Franse}, L.V. and F. Pouwer and M.S.Y. Thong",
year = "2016",
doi = "10.1007/s11764-015-0486-3",
language = "English",
volume = "10",
pages = "406--415",
journal = "Journal of Cancer Survivorship",
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The impact of having both cancer and diabetes on patient-reported outcomes : A systematic review and directions for future research. / Vissers, P.A.J.; Falzon, L.; van de Poll-Franse, L.V.; Pouwer, F.; Thong, M.S.Y.

In: Journal of Cancer Survivorship, Vol. 10, No. 2, 2016, p. 406-415.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The impact of having both cancer and diabetes on patient-reported outcomes

T2 - A systematic review and directions for future research

AU - Vissers, P.A.J.

AU - Falzon, L.

AU - van de Poll-Franse, L.V.

AU - Pouwer, F.

AU - Thong, M.S.Y.

PY - 2016

Y1 - 2016

N2 - PurposeThis systematic review aims to summarize the current literature regarding potential effects of having both cancer and diabetes on patient-reported outcomes (PROs) and to provide directions for future research.MethodsMEDLINE, The Cochrane Library, CINAHL, and PsycINFO were searched from inception to January 2015. All English peer-reviewed studies that included patients with both cancer and diabetes and assessed PROs were included. All included studies were independently assessed on methodological quality by two investigators.ResultsOf the 3553 identified studies, 10 studies were included and all were considered of high (40 %) or adequate (60 %) methodological quality. Eight of the 10 studies focused on health-related quality of life (HRQoL), functioning, or symptoms and 2 studies assessed diabetes self-management. Overall, HRQoL and functioning was lower, and symptoms were higher among patients with both cancer and diabetes as compared to having cancer or diabetes alone. Furthermore, one study reported that diabetes self-management was impaired after chemotherapy.ConclusionsHaving both cancer and diabetes resulted in worse PROs compared to having either one of the diseases, however, the considerable heterogeneity of the included studies hampered strong conclusions. Future studies are needed as this research area is largely neglected. As the majority of the included studies focused on HRQoL, future research should address the impact of both diseases on other PROs such as depression, patient empowerment and self-management.Implications for Cancer SurvivorHaving both cancer and diabetes might result in worse PROs, however, more research is needed as current evidence is scarce.KeywordsCancer, Diabetes, Patient-reported outcomes, Systematic review, Health-related quality of life

AB - PurposeThis systematic review aims to summarize the current literature regarding potential effects of having both cancer and diabetes on patient-reported outcomes (PROs) and to provide directions for future research.MethodsMEDLINE, The Cochrane Library, CINAHL, and PsycINFO were searched from inception to January 2015. All English peer-reviewed studies that included patients with both cancer and diabetes and assessed PROs were included. All included studies were independently assessed on methodological quality by two investigators.ResultsOf the 3553 identified studies, 10 studies were included and all were considered of high (40 %) or adequate (60 %) methodological quality. Eight of the 10 studies focused on health-related quality of life (HRQoL), functioning, or symptoms and 2 studies assessed diabetes self-management. Overall, HRQoL and functioning was lower, and symptoms were higher among patients with both cancer and diabetes as compared to having cancer or diabetes alone. Furthermore, one study reported that diabetes self-management was impaired after chemotherapy.ConclusionsHaving both cancer and diabetes resulted in worse PROs compared to having either one of the diseases, however, the considerable heterogeneity of the included studies hampered strong conclusions. Future studies are needed as this research area is largely neglected. As the majority of the included studies focused on HRQoL, future research should address the impact of both diseases on other PROs such as depression, patient empowerment and self-management.Implications for Cancer SurvivorHaving both cancer and diabetes might result in worse PROs, however, more research is needed as current evidence is scarce.KeywordsCancer, Diabetes, Patient-reported outcomes, Systematic review, Health-related quality of life

U2 - 10.1007/s11764-015-0486-3

DO - 10.1007/s11764-015-0486-3

M3 - Article

VL - 10

SP - 406

EP - 415

JO - Journal of Cancer Survivorship

JF - Journal of Cancer Survivorship

SN - 1932-2259

IS - 2

ER -