The impact of prostate cancer diagnosis and treatment decision-making on health-related quality of life before treatment onset

M. Cuypers, R. Lamers, E.B. Cornel, L.V. van de Poll-Franse, M. de Vries, P.J.M. Kil

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)
23 Downloads (Pure)

Abstract

Objective:
The objective of this study is to test if patients' health-related quality of life (HRQoL) declines after prostate biopsy to detect Pca, and after subsequent treatment decision-making in case Pca is confirmed, and to test whether personality state and traits are associated with these potential changes in HRQoL.
Methods:
Patients who were scheduled for prostate biopsy to detect Pca (N = 377) filled out a baseline questionnaire about HRQoL (EORTC QLQ-C30 and PR25), "big five" personality traits (BFI-10), optimism (LOT-r), and self-efficacy (Decision Self-efficacy Scale) (t0). Patients with confirmed Pca (N = 126) filled out a follow-up questionnaire on HRQoL within 2 weeks after treatment was chosen but had not yet started (t1).
Results:
HRQoL declined between t0 and t1, reflected in impaired role and cognitive functioning, and elevated fatigue, constipation, and prostate-specific symptoms. Sexual activity and functioning improved. Baseline HRQoL scores were unrelated to the selection of a particular treatment, but for patients who chose a curative treatment, post-decision HRQoL showed a greater decline compared to patients who chose active surveillance. Optimism was associated with HRQoL at baseline; decisional self-efficacy was positively associated with HRQoL at follow-up. No associations between HRQoL and the "big five" personality traits were found.
Conclusion:
Patients who have undergone prostate biopsy and treatment decision-making for Pca experience a decline in HRQoL. Choosing treatment with a curative intent was associated with greater decline in HRQoL. Interventions aimed at optimism and decision self-efficacy could be helpful to reduce HRQoL impairment around the time of prostate biopsy and treatment decision-making
Original languageEnglish
Pages (from-to)1297-1304
JournalSupportive Care in Cancer
Volume26
Issue number4
DOIs
Publication statusPublished - 2018

Keywords

  • ACTIVE SURVEILLANCE
  • Cancer
  • DISTRESS
  • Decision-making
  • Decisional self-efficacy
  • Diagnosis
  • HRQoL
  • MEN
  • OLDER AMERICANS
  • Oncology
  • Optimism
  • PERSONALITY
  • Prostate cancer
  • SURVIVORS
  • THREAT
  • URINARY

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