The individual and combined effect of colorectal cancer and diabetes on health-related quality of life and sexual functioning

Results from the PROFILES registry

P.A.J. Vissers, M.S.Y. Thong, F. Pouwer, B.L. den Oudsten, Grard A. P. Nieuwenhuijzen, L.V. van de Poll-Franse

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Purpose
This study examined the individual and combined effect of having colorectal cancer (CRC) and diabetes mellitus (DM) on health-related quality of life (HRQoL) and sexual functioning.
Methods
Data from questionnaires collected in 2010 among CRC patients and a sample of the general Dutch population were used. All persons older than 60 years were included in this study. DM prevalence among the CRC sample as well as the sample of the general population was self-reported. HRQoL was measured using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30), and sexual functioning was assessed with four scales from the EORTC-QLQ-CR38.
Results
In total 624 persons without CRC and DM, 78 persons with DM only, 1,731 with CRC only, and 328 with both CRC and DM were included. Having both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. CRC, irrespective of having DM, was associated with lower scores on most EORTC-QLQ-C30 subscales, except global health, pain, and appetite loss. CRC was also independently associated with more erection problems among males. DM, irrespective of having CRC, was associated with lower physical functioning and more symptoms of dyspnea.
Conclusions
Having both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. As CRC was found to be consistently associated with lower functioning and more symptoms, CRC and its treatment seem to contribute stronger to lower HRQoL and sexual functioning compared with DM.
Original languageEnglish
Pages (from-to)3071-3079
JournalSupportive Care in Cancer
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 2014

Keywords

  • Cancer
  • Diabetes
  • Health-related quality of life
  • Sexual functioning

Cite this

@article{8cfc7b8ae5664e249ccd0d3aefa47ae4,
title = "The individual and combined effect of colorectal cancer and diabetes on health-related quality of life and sexual functioning: Results from the PROFILES registry",
abstract = "PurposeThis study examined the individual and combined effect of having colorectal cancer (CRC) and diabetes mellitus (DM) on health-related quality of life (HRQoL) and sexual functioning.MethodsData from questionnaires collected in 2010 among CRC patients and a sample of the general Dutch population were used. All persons older than 60 years were included in this study. DM prevalence among the CRC sample as well as the sample of the general population was self-reported. HRQoL was measured using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30), and sexual functioning was assessed with four scales from the EORTC-QLQ-CR38.ResultsIn total 624 persons without CRC and DM, 78 persons with DM only, 1,731 with CRC only, and 328 with both CRC and DM were included. Having both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. CRC, irrespective of having DM, was associated with lower scores on most EORTC-QLQ-C30 subscales, except global health, pain, and appetite loss. CRC was also independently associated with more erection problems among males. DM, irrespective of having CRC, was associated with lower physical functioning and more symptoms of dyspnea.ConclusionsHaving both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. As CRC was found to be consistently associated with lower functioning and more symptoms, CRC and its treatment seem to contribute stronger to lower HRQoL and sexual functioning compared with DM.",
keywords = "Cancer, Diabetes, Health-related quality of life, Sexual functioning",
author = "P.A.J. Vissers and M.S.Y. Thong and F. Pouwer and {den Oudsten}, B.L. and Nieuwenhuijzen, {Grard A. P.} and {van de Poll-Franse}, L.V.",
year = "2014",
month = "11",
doi = "10.1007/s00520-014-2292-2",
language = "English",
volume = "22",
pages = "3071--3079",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "11",

}

The individual and combined effect of colorectal cancer and diabetes on health-related quality of life and sexual functioning : Results from the PROFILES registry. / Vissers, P.A.J.; Thong, M.S.Y.; Pouwer, F.; den Oudsten, B.L.; Nieuwenhuijzen, Grard A. P.; van de Poll-Franse, L.V.

In: Supportive Care in Cancer, Vol. 22, No. 11, 11.2014, p. 3071-3079.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The individual and combined effect of colorectal cancer and diabetes on health-related quality of life and sexual functioning

T2 - Results from the PROFILES registry

AU - Vissers, P.A.J.

AU - Thong, M.S.Y.

AU - Pouwer, F.

AU - den Oudsten, B.L.

AU - Nieuwenhuijzen, Grard A. P.

AU - van de Poll-Franse, L.V.

PY - 2014/11

Y1 - 2014/11

N2 - PurposeThis study examined the individual and combined effect of having colorectal cancer (CRC) and diabetes mellitus (DM) on health-related quality of life (HRQoL) and sexual functioning.MethodsData from questionnaires collected in 2010 among CRC patients and a sample of the general Dutch population were used. All persons older than 60 years were included in this study. DM prevalence among the CRC sample as well as the sample of the general population was self-reported. HRQoL was measured using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30), and sexual functioning was assessed with four scales from the EORTC-QLQ-CR38.ResultsIn total 624 persons without CRC and DM, 78 persons with DM only, 1,731 with CRC only, and 328 with both CRC and DM were included. Having both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. CRC, irrespective of having DM, was associated with lower scores on most EORTC-QLQ-C30 subscales, except global health, pain, and appetite loss. CRC was also independently associated with more erection problems among males. DM, irrespective of having CRC, was associated with lower physical functioning and more symptoms of dyspnea.ConclusionsHaving both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. As CRC was found to be consistently associated with lower functioning and more symptoms, CRC and its treatment seem to contribute stronger to lower HRQoL and sexual functioning compared with DM.

AB - PurposeThis study examined the individual and combined effect of having colorectal cancer (CRC) and diabetes mellitus (DM) on health-related quality of life (HRQoL) and sexual functioning.MethodsData from questionnaires collected in 2010 among CRC patients and a sample of the general Dutch population were used. All persons older than 60 years were included in this study. DM prevalence among the CRC sample as well as the sample of the general population was self-reported. HRQoL was measured using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30), and sexual functioning was assessed with four scales from the EORTC-QLQ-CR38.ResultsIn total 624 persons without CRC and DM, 78 persons with DM only, 1,731 with CRC only, and 328 with both CRC and DM were included. Having both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. CRC, irrespective of having DM, was associated with lower scores on most EORTC-QLQ-C30 subscales, except global health, pain, and appetite loss. CRC was also independently associated with more erection problems among males. DM, irrespective of having CRC, was associated with lower physical functioning and more symptoms of dyspnea.ConclusionsHaving both CRC and DM did not result in lower HRQoL and sexual functioning than the sum of the individual effects of both diseases. As CRC was found to be consistently associated with lower functioning and more symptoms, CRC and its treatment seem to contribute stronger to lower HRQoL and sexual functioning compared with DM.

KW - Cancer

KW - Diabetes

KW - Health-related quality of life

KW - Sexual functioning

U2 - 10.1007/s00520-014-2292-2

DO - 10.1007/s00520-014-2292-2

M3 - Article

VL - 22

SP - 3071

EP - 3079

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 11

ER -