The secret ingredient for social success of young males

A functional polymorphism in in the 5HT2A serotonin receptor gene

J.K. Dijkstra, S.M. Lindenberg, L. Zijlstra, E. Bouma, R. Veenstra

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

In adolescence, being socially successful depends to a large extent on being popular with peers. Even though some youths have what it takes to be popular, they are not, whereas others seem to have a secret ingredient that just makes the difference. In this study the G-allele of a functional polymorphism in the promotor region of the 5HT2A serotonin receptor gene (-G1438A) was identified as a secret ingredient for popularity among peers. These findings build on and extend previous work by Burt (2008, 2009). Tackling limitations from previous research, the role of the 5HT2A serotonin receptor gene was examined in adolescent males (N = 285; average age 13) using a unique sample of the TRAILS study. Carrying the G-allele enhanced the relation between aggression and popularity, particularly for those boys who have many female friends. This seems to be an “enhancer” effect of the G-allele whereby popularity relevant characteristics are made more noticeable. There is no “popularity gene”, as the G-allele by itself had no effect on popularity.
Original languageEnglish
Article numbere54821
JournalPLoS ONE
Volume8
Issue number2
DOIs
Publication statusPublished - 2013

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Serotonin Receptors
Polymorphism
Genes
Alleles
Genetic Promoter Regions

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title = "The secret ingredient for social success of young males: A functional polymorphism in in the 5HT2A serotonin receptor gene",
abstract = "In adolescence, being socially successful depends to a large extent on being popular with peers. Even though some youths have what it takes to be popular, they are not, whereas others seem to have a secret ingredient that just makes the difference. In this study the G-allele of a functional polymorphism in the promotor region of the 5HT2A serotonin receptor gene (-G1438A) was identified as a secret ingredient for popularity among peers. These findings build on and extend previous work by Burt (2008, 2009). Tackling limitations from previous research, the role of the 5HT2A serotonin receptor gene was examined in adolescent males (N = 285; average age 13) using a unique sample of the TRAILS study. Carrying the G-allele enhanced the relation between aggression and popularity, particularly for those boys who have many female friends. This seems to be an “enhancer” effect of the G-allele whereby popularity relevant characteristics are made more noticeable. There is no “popularity gene”, as the G-allele by itself had no effect on popularity.",
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The secret ingredient for social success of young males : A functional polymorphism in in the 5HT2A serotonin receptor gene. / Dijkstra, J.K.; Lindenberg, S.M.; Zijlstra, L.; Bouma, E.; Veenstra, R.

In: PLoS ONE, Vol. 8, No. 2, e54821, 2013.

Research output: Contribution to journalArticleScientificpeer-review

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