The temporal pattern of a lesion modulates the functional network topology of remote brain regions

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Abstract

Focal brain lesions can alter the morphology and function of remote brain areas. When the damage is inflicted more slowly, the functional compensation by and structural reshaping of these remote areas seems to be more effective. It remains unclear, however, whether the momentum of lesion development also modulates the functional network topology of the remote brain areas. In this study, we compared resting-state functional connectivity data of patients with a slowly-growing low-grade glioma (LGG) with that of patients with a faster-growing high-grade glioma (HGG). Using graph theory, we examined whether the tumour growth velocity modulated the functional network topology of remote areas, more specifically of the hemisphere contralateral to the lesion. We observed that the contralesional network topology characteristics differed between patient groups. Based only on the connectivity of the hemisphere contralateral to the lesion, patients could be classified in the correct tumour-grade group with 70% accuracy. Additionally, LGG patients showed smaller contralesional Intra-modular connectivity, smaller contralesional ratio between Intra- and Inter-modular connectivity and larger contralesional Inter-modular connectivity than HGG patients. These results suggest that, in the hemisphere contralateral to the lesion, there is a lower capacity for local, specialized information processing coupled to a higher capacity for distributed information processing in LGG patients. These results underline the utility of a network perspective in evaluating effects of focal brain injury.
Original languageEnglish
Article number3530723
JournalNeural Plasticity
Volume2017
DOIs
Publication statusPublished - 2017

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@article{cc4a8d12e6c0429392981e9eb5f13d82,
title = "The temporal pattern of a lesion modulates the functional network topology of remote brain regions",
abstract = "Focal brain lesions can alter the morphology and function of remote brain areas. When the damage is inflicted more slowly, the functional compensation by and structural reshaping of these remote areas seems to be more effective. It remains unclear, however, whether the momentum of lesion development also modulates the functional network topology of the remote brain areas. In this study, we compared resting-state functional connectivity data of patients with a slowly-growing low-grade glioma (LGG) with that of patients with a faster-growing high-grade glioma (HGG). Using graph theory, we examined whether the tumour growth velocity modulated the functional network topology of remote areas, more specifically of the hemisphere contralateral to the lesion. We observed that the contralesional network topology characteristics differed between patient groups. Based only on the connectivity of the hemisphere contralateral to the lesion, patients could be classified in the correct tumour-grade group with 70{\%} accuracy. Additionally, LGG patients showed smaller contralesional Intra-modular connectivity, smaller contralesional ratio between Intra- and Inter-modular connectivity and larger contralesional Inter-modular connectivity than HGG patients. These results suggest that, in the hemisphere contralateral to the lesion, there is a lower capacity for local, specialized information processing coupled to a higher capacity for distributed information processing in LGG patients. These results underline the utility of a network perspective in evaluating effects of focal brain injury.",
author = "{De Baene}, W. and G.J.M. Rutten and M.M. Sitskoorn",
year = "2017",
doi = "10.1155/2017/3530723",
language = "English",
volume = "2017",
journal = "Neural Plasticity",
issn = "0792-8483",
publisher = "Walter de Gruyter GmbH",

}

The temporal pattern of a lesion modulates the functional network topology of remote brain regions. / De Baene, W.; Rutten, G.J.M.; Sitskoorn, M.M.

In: Neural Plasticity, Vol. 2017, 3530723, 2017.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - The temporal pattern of a lesion modulates the functional network topology of remote brain regions

AU - De Baene, W.

AU - Rutten, G.J.M.

AU - Sitskoorn, M.M.

PY - 2017

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N2 - Focal brain lesions can alter the morphology and function of remote brain areas. When the damage is inflicted more slowly, the functional compensation by and structural reshaping of these remote areas seems to be more effective. It remains unclear, however, whether the momentum of lesion development also modulates the functional network topology of the remote brain areas. In this study, we compared resting-state functional connectivity data of patients with a slowly-growing low-grade glioma (LGG) with that of patients with a faster-growing high-grade glioma (HGG). Using graph theory, we examined whether the tumour growth velocity modulated the functional network topology of remote areas, more specifically of the hemisphere contralateral to the lesion. We observed that the contralesional network topology characteristics differed between patient groups. Based only on the connectivity of the hemisphere contralateral to the lesion, patients could be classified in the correct tumour-grade group with 70% accuracy. Additionally, LGG patients showed smaller contralesional Intra-modular connectivity, smaller contralesional ratio between Intra- and Inter-modular connectivity and larger contralesional Inter-modular connectivity than HGG patients. These results suggest that, in the hemisphere contralateral to the lesion, there is a lower capacity for local, specialized information processing coupled to a higher capacity for distributed information processing in LGG patients. These results underline the utility of a network perspective in evaluating effects of focal brain injury.

AB - Focal brain lesions can alter the morphology and function of remote brain areas. When the damage is inflicted more slowly, the functional compensation by and structural reshaping of these remote areas seems to be more effective. It remains unclear, however, whether the momentum of lesion development also modulates the functional network topology of the remote brain areas. In this study, we compared resting-state functional connectivity data of patients with a slowly-growing low-grade glioma (LGG) with that of patients with a faster-growing high-grade glioma (HGG). Using graph theory, we examined whether the tumour growth velocity modulated the functional network topology of remote areas, more specifically of the hemisphere contralateral to the lesion. We observed that the contralesional network topology characteristics differed between patient groups. Based only on the connectivity of the hemisphere contralateral to the lesion, patients could be classified in the correct tumour-grade group with 70% accuracy. Additionally, LGG patients showed smaller contralesional Intra-modular connectivity, smaller contralesional ratio between Intra- and Inter-modular connectivity and larger contralesional Inter-modular connectivity than HGG patients. These results suggest that, in the hemisphere contralateral to the lesion, there is a lower capacity for local, specialized information processing coupled to a higher capacity for distributed information processing in LGG patients. These results underline the utility of a network perspective in evaluating effects of focal brain injury.

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