Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older

Ylva Köhncke, Erika J. Laukka, Yvonne Brehmer, Grégoria Kalpouzos, Tie-qiang Li, Laura Fratiglioni, Lars Bäckman, Martin Lövdén

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Abstract

Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.
Original languageEnglish
Pages (from-to)173-186
JournalNeurobiology of Aging
Volume41
DOIs
Publication statusPublished - 1 May 2016
Externally publishedYes

Fingerprint Dive into the research topics of 'Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older'. Together they form a unique fingerprint.

  • Cite this