Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older

Ylva Köhncke, Erika J. Laukka, Yvonne Brehmer, Grégoria Kalpouzos, Tie-qiang Li, Laura Fratiglioni, Lars Bäckman, Martin Lövdén

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.
Original languageEnglish
Pages (from-to)173-186
JournalNeurobiology of Aging
Volume41
DOIs
Publication statusPublished - 1 May 2016
Externally publishedYes

Fingerprint

Leisure Activities
Diffusion Tensor Imaging

Cite this

Köhncke, Ylva ; Laukka, Erika J. ; Brehmer, Yvonne ; Kalpouzos, Grégoria ; Li, Tie-qiang ; Fratiglioni, Laura ; Bäckman, Lars ; Lövdén, Martin. / Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older. In: Neurobiology of Aging. 2016 ; Vol. 41. pp. 173-186.
@article{53554f4b337646c68f811ab57f48e073,
title = "Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older",
abstract = "Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.",
author = "Ylva K{\"o}hncke and Laukka, {Erika J.} and Yvonne Brehmer and Gr{\'e}goria Kalpouzos and Tie-qiang Li and Laura Fratiglioni and Lars B{\"a}ckman and Martin L{\"o}vd{\'e}n",
year = "2016",
month = "5",
day = "1",
doi = "10.1016/j.neurobiolaging.2016.02.013",
language = "English",
volume = "41",
pages = "173--186",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older. / Köhncke, Ylva; Laukka, Erika J.; Brehmer, Yvonne; Kalpouzos, Grégoria; Li, Tie-qiang; Fratiglioni, Laura; Bäckman, Lars; Lövdén, Martin.

In: Neurobiology of Aging, Vol. 41, 01.05.2016, p. 173-186.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older

AU - Köhncke, Ylva

AU - Laukka, Erika J.

AU - Brehmer, Yvonne

AU - Kalpouzos, Grégoria

AU - Li, Tie-qiang

AU - Fratiglioni, Laura

AU - Bäckman, Lars

AU - Lövdén, Martin

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.

AB - Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.

U2 - 10.1016/j.neurobiolaging.2016.02.013

DO - 10.1016/j.neurobiolaging.2016.02.013

M3 - Article

VL - 41

SP - 173

EP - 186

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -