Tidal volumes at birth as predictor for adverse outcome in congenital diaphragmatic hernia

Arenda Mank, Cristina Carrasco Carrasco, Marta Thio, Jordi Clotet, Steffen C. Pauws, Philip DeKoninck, Arjan B. te Pas*

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review

    10 Citations (Scopus)

    Abstract

    Objective To assess the predictive value of tidal volume (Vt) of spontaneous breaths at birth in infants with congenital diaphragmatic hernia (CDH).

    Design Prospective study.

    Setting Tertiary neonatal intensive care unit.

    Patients Thirty infants with antenatally diagnosed CDH born at Hospital Sant Joan de Deu in Barcelona from September 2013 to September 2015.

    Interventions Spontaneous breaths and inflations given in the first 10 min after intubation at birth were recorded using respiratory function monitor. Only expired Vt of uninterrupted spontaneous breaths was included for analysis. Receiver operating characteristics (ROC) analysis was performed and the area under the curve (AUC) was estimated to assess the predictive accuracy of Vt.

    Main outcome measures Mortality before hospital discharge and chronic lung disease (CLD) at day 28 of life.

    Results There were 1.233 uninterrupted spontaneous breaths measured, and the overall mean Vt was 2.8 +/- 2.1 mL/kg. A lower Vt was found in infants who died (n=14) compared with survivors (n=16) (1.7 +/- 1.6 vs 3.7 +/- 2.1 mL/kg; p=0.008). Vt was lower in infants who died during admission or had CLD (n=20) compared with survivors without CLD (n=10) (2.0 +/- 1.7 vs 4.3 +/- 2.2 mL/kg; p=0.004). ROC analysis showed that Vt

    Conclusion Vt of spontaneous breaths measured immediately after birth is associated with mortality and CLD. Vt seems to be a reliable predictor but is not an independent predictor after adjustment for observed/expected lung to head ratio and liver position.

    Original languageEnglish
    Pages (from-to)F248-F252
    Number of pages5
    JournalArchives of Disease in Childhood. Fetal and Neonatal Edition
    Volume105
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2020

    Keywords

    • FREQUENCY OSCILLATORY VENTILATION
    • TO-HEAD RATIO
    • PULMONARY-HYPERTENSION
    • LUNG HYPOPLASIA
    • EPIDEMIOLOGY
    • MANAGEMENT
    • FETUSES
    • INFANTS

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