Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Research output: Contribution to journalArticleScientificpeer-review

Abstract

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
Original languageUndefined/Unknown
JournalNature Genetics
DOIs
Publication statusPublished - 21 Dec 2018
Externally publishedYes

Cite this

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title = "Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.",
abstract = "In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.",
author = "Ruifang Li",
year = "2018",
month = "12",
day = "21",
doi = "10.1038/s41588-018-0303-9",
language = "Undefined/Unknown",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",

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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. / Li, Ruifang.

In: Nature Genetics, 21.12.2018.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

AU - Li, Ruifang

PY - 2018/12/21

Y1 - 2018/12/21

N2 - In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.

AB - In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.

UR - http://europepmc.org/articles/PMC6365102

U2 - 10.1038/s41588-018-0303-9

DO - 10.1038/s41588-018-0303-9

M3 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -