Translational nanomedicine

Through the therapeutic window

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Translational nanomedicine occurs only through the successful integration of multiple inputs and iterative modifications. The therapeutic window plays a pivotal role in the trajectory of translational nanomedicine. Often defined in terms of the range of dosage for safe and effective therapeutic effect, a second definition of the therapeutic window refers to the often narrow temporal window in which a therapeutic effect can be obtained. Expanding the second definition to explicitly include the spatial dimension, this article explores aspects of the therapeutic spaces created by nanomedicine that shift the traditional dimensions of symptom, sign and pathology. This article analyzes three aspects of the therapeutic window in nanomedicine – temporal, spatial and manner of construction and their impact on the dimensions of modern medicine.
Original languageEnglish
Pages (from-to)3249-3260
Number of pages12
JournalNanomedicine
Volume10
Issue number21
DOIs
Publication statusPublished - 16 Oct 2015

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Medical nanotechnology
Therapeutic Uses
Modern 1601-history
Pathology
Medicine
Trajectories

Keywords

  • nanoethics; nanomedicine; patient-centered research; therapeutic window; translational research

Cite this

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Translational nanomedicine : Through the therapeutic window. / Pierce, Robin.

In: Nanomedicine , Vol. 10, No. 21, 16.10.2015, p. 3249-3260.

Research output: Contribution to journalArticleScientificpeer-review

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