Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors

Results from the population-based PROFILES registry

S. Verhaar, P.A.J. Vissers, H. Maas, L.V. van de Poll-Franse, F.N. van Erning, F. Mols

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background
The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population.
Methods
Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685).
Results
1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population.
Conclusion
No differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy
Original languageEnglish
Pages (from-to)1263–1273
JournalEuropean Journal of Cancer
Volume51
Issue number10
DOIs
Publication statusPublished - 2015

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Survivors
Organizations
Adjuvant Chemotherapy
Neoplasms

Cite this

@article{f0494e020a2245c69aa2d990ab717f4f,
title = "Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry",
abstract = "BackgroundThe goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population.MethodsPatients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685).Results1606 (72{\%}) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population.ConclusionNo differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy",
author = "S. Verhaar and P.A.J. Vissers and H. Maas and {van de Poll-Franse}, L.V. and {van Erning}, F.N. and F. Mols",
year = "2015",
doi = "10.1016/j.ejca.2015.04.004",
language = "English",
volume = "51",
pages = "1263–1273",
journal = "European Journal of Cancer",
issn = "0964-1947",
number = "10",

}

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors : Results from the population-based PROFILES registry. / Verhaar, S.; Vissers, P.A.J.; Maas, H.; van de Poll-Franse, L.V.; van Erning, F.N.; Mols, F.

In: European Journal of Cancer, Vol. 51, No. 10, 2015, p. 1263–1273.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors

T2 - Results from the population-based PROFILES registry

AU - Verhaar, S.

AU - Vissers, P.A.J.

AU - Maas, H.

AU - van de Poll-Franse, L.V.

AU - van Erning, F.N.

AU - Mols, F.

PY - 2015

Y1 - 2015

N2 - BackgroundThe goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population.MethodsPatients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685).Results1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population.ConclusionNo differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy

AB - BackgroundThe goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population.MethodsPatients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685).Results1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population.ConclusionNo differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy

U2 - 10.1016/j.ejca.2015.04.004

DO - 10.1016/j.ejca.2015.04.004

M3 - Article

VL - 51

SP - 1263

EP - 1273

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0964-1947

IS - 10

ER -