Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

S. Verhaar; P.A.J. Vissers; H. Maas; L.V. van de Poll-Franse; F.N. van Erning; F. Mols

doi:10.1016/j.ejca.2015.04.004

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

S. Verhaar
, P.A.J. Vissers
, H. Maas
, L.V. van de Poll-Franse
, F.N. van Erning
, F. Mols

Medical and Clinical Psychology

Research output: Contribution to journal › Article › Scientific › peer-review

22 Citations (Scopus)

Abstract

Background
The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population.
Methods
Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685).
Results
1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population.
Conclusion
No differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy

Original language	English
Pages (from-to)	1263–1273
Journal	European Journal of Cancer
Volume	51
Issue number	10
DOIs	https://doi.org/10.1016/j.ejca.2015.04.004
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ejca.2015.04.004

Cite this

Verhaar, S., Vissers, P. A. J., Maas, H., van de Poll-Franse, L. V., van Erning, F. N., & Mols, F. (2015). Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry. European Journal of Cancer, 51(10), 1263–1273. https://doi.org/10.1016/j.ejca.2015.04.004

@article{f0494e020a2245c69aa2d990ab717f4f,

title = "Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry",

abstract = "Background The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population. Methods Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685). Results 1606 (72\%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population. Conclusion No differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy",

author = "S. Verhaar and P.A.J. Vissers and H. Maas and \{van de Poll-Franse\}, L.V. and \{van Erning\}, F.N. and F. Mols",

year = "2015",

doi = "10.1016/j.ejca.2015.04.004",

language = "English",

volume = "51",

pages = "1263–1273",

journal = "European Journal of Cancer",

issn = "0964-1947",

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Verhaar, S, Vissers, PAJ, Maas, H, van de Poll-Franse, LV, van Erning, FN & Mols, F 2015, 'Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry', European Journal of Cancer, vol. 51, no. 10, pp. 1263–1273. https://doi.org/10.1016/j.ejca.2015.04.004

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry. / Verhaar, S.; Vissers, P.A.J.; Maas, H. et al.
In: European Journal of Cancer, Vol. 51, No. 10, 2015, p. 1263–1273.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors

T2 - Results from the population-based PROFILES registry

AU - Verhaar, S.

AU - Vissers, P.A.J.

AU - Maas, H.

AU - van de Poll-Franse, L.V.

AU - van Erning, F.N.

AU - Mols, F.

PY - 2015

Y1 - 2015

N2 - Background The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population. Methods Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685). Results 1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population. Conclusion No differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy

AB - Background The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population. Methods Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685). Results 1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population. Conclusion No differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy

U2 - 10.1016/j.ejca.2015.04.004

DO - 10.1016/j.ejca.2015.04.004

M3 - Article

SN - 0964-1947

VL - 51

SP - 1263

EP - 1273

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 10

ER -

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

Abstract

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