Unresolved-disorganized attachment adjusted for a General Psychopathology Factor associated with atypical amygdala resting-state functional connectivity

Marie-Jose van Hoof*, M.M.E. Riem, Amy Garrett, Nic van der Wee, Marinus van IJzendoorn, Robert Vermeiren

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Background:
Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characteristics within diagnostic classifications.

Objective:
In the current study, we examined unique relations of resting-state functional connectivity (RSFC) with Ud and GPF.

Method:
RSFC data were collected from a mixed group of adolescents (N = 74) with and without psychiatric disorder, as part of the Emotional Pathways’ Imaging Study in Clinical Adolescents (EPISCA) study. Ud was measured using the Adult Attachment Interview (AAI). Associations between Ud, GPF, and RSFC of the amygdala and dorsal anterior cingulate cortex (dACC) and with amygdala–medial frontal connectivity were examined.

Results:
Ud was positively associated with greater functional connectivity between the left amygdala and the left lateral occipital cortex, precuneus, and superior parietal lobule. Furthermore, Ud was negatively associated with left amygdala–medial frontal cortex connectivity. GPF was not significantly associated with dACC or amygdala connectivity.

Conclusions:
Atypical amygdala connectivity may reflect a vulnerability factor rather than a biomarker of psychopathology. The unique association of Ud and amygdala RSFC, adjusted for a GPF, across participants with and without various classifications of psychopathology illustrates that dimensional approaches based on the AAI may complement psychiatric classifications in clinical research and practice.
Original languageEnglish
Article number1583525
JournalEuropean Journal of Psychotraumatology
Volume10
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • ABUSE
  • ADOLESCENTS
  • ADULT ATTACHMENT
  • ANXIETY
  • CHILDHOOD
  • DISORDER
  • EXPERIENCES
  • General psychopathology factor
  • MEDIAL FRONTAL-CORTEX
  • NETWORKS
  • SALIENCE
  • adolescents
  • amygdala
  • dorsal anterior cingulate cortex
  • medial prefrontal cortex
  • psychopathology
  • resting-state functional connectivity
  • unresolved-disorganized attachment

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