Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

Mirjam J G Van Manen, Monique Wapenaar, Bert Strookappe, Marjolein Drent, Marjon Elfferich, J. De Vries, Harry R Gosker, Surinder S Birring, Amit S Patel, Leon Van den Toorn, Bernt Van den Blink, Karin Boomars, Elske Hoitsma, Marlies S Wijsenbeek

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background 

The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.Objective The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.

Methods

The KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.

Results 

Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach's α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.

Conclusion

The Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.

Original languageEnglish
Pages (from-to)75-82
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume33
Issue number1
Publication statusPublished - 2016

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Surveys and Questionnaires
Eye Diseases
Outpatients
Interviews

Cite this

Van Manen, M. J. G., Wapenaar, M., Strookappe, B., Drent, M., Elfferich, M., De Vries, J., ... Wijsenbeek, M. S. (2016). Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population. Sarcoidosis Vasculitis and Diffuse Lung Diseases, 33(1), 75-82.
Van Manen, Mirjam J G ; Wapenaar, Monique ; Strookappe, Bert ; Drent, Marjolein ; Elfferich, Marjon ; De Vries, J. ; Gosker, Harry R ; Birring, Surinder S ; Patel, Amit S ; Van den Toorn, Leon ; Van den Blink, Bernt ; Boomars, Karin ; Hoitsma, Elske ; Wijsenbeek, Marlies S. / Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population. In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2016 ; Vol. 33, No. 1. pp. 75-82.
@article{f85efaf57733439aa8ba7e5a0a810fc2,
title = "Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population",
abstract = "Background The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.Objective The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.MethodsThe KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.Results Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach's α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.ConclusionThe Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.",
author = "{Van Manen}, {Mirjam J G} and Monique Wapenaar and Bert Strookappe and Marjolein Drent and Marjon Elfferich and {De Vries}, J. and Gosker, {Harry R} and Birring, {Surinder S} and Patel, {Amit S} and {Van den Toorn}, Leon and {Van den Blink}, Bernt and Karin Boomars and Elske Hoitsma and Wijsenbeek, {Marlies S}",
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language = "English",
volume = "33",
pages = "75--82",
journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases",
issn = "1124-0490",
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number = "1",

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Van Manen, MJG, Wapenaar, M, Strookappe, B, Drent, M, Elfferich, M, De Vries, J, Gosker, HR, Birring, SS, Patel, AS, Van den Toorn, L, Van den Blink, B, Boomars, K, Hoitsma, E & Wijsenbeek, MS 2016, 'Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population', Sarcoidosis Vasculitis and Diffuse Lung Diseases, vol. 33, no. 1, pp. 75-82.

Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population. / Van Manen, Mirjam J G; Wapenaar, Monique; Strookappe, Bert; Drent, Marjolein; Elfferich, Marjon; De Vries, J.; Gosker, Harry R; Birring, Surinder S; Patel, Amit S; Van den Toorn, Leon; Van den Blink, Bernt; Boomars, Karin; Hoitsma, Elske; Wijsenbeek, Marlies S.

In: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Vol. 33, No. 1, 2016, p. 75-82.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

AU - Van Manen, Mirjam J G

AU - Wapenaar, Monique

AU - Strookappe, Bert

AU - Drent, Marjolein

AU - Elfferich, Marjon

AU - De Vries, J.

AU - Gosker, Harry R

AU - Birring, Surinder S

AU - Patel, Amit S

AU - Van den Toorn, Leon

AU - Van den Blink, Bernt

AU - Boomars, Karin

AU - Hoitsma, Elske

AU - Wijsenbeek, Marlies S

PY - 2016

Y1 - 2016

N2 - Background The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.Objective The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.MethodsThe KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.Results Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach's α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.ConclusionThe Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.

AB - Background The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.Objective The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.MethodsThe KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.Results Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach's α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.ConclusionThe Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.

M3 - Article

VL - 33

SP - 75

EP - 82

JO - Sarcoidosis Vasculitis and Diffuse Lung Diseases

JF - Sarcoidosis Vasculitis and Diffuse Lung Diseases

SN - 1124-0490

IS - 1

ER -