Variation in the serotonin transporter polymorphism (5-HTTLPR) and inertia of negative and positive emotions in daily life

G.H. van Roekel, Maaike Verhagen, Rutger C M E Engels, Peter Kuppens

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)
35 Downloads (Pure)

Abstract

An important element of understanding the genotype-phenotype link in psychiatric disorders lies in identifying the psychological mechanisms through which genetic variation impacts mental health. Here we examined whether emotional inertia, the tendency for a person's emotions to carry over from 1 moment to the next and a prospective predictor of the development of depression, is associated with a known genetic risk factor for emotional dysregulation, a polymorphism in the serotonin transporter gene (5-HTTLPR). Two hundred thirty-six adolescents recorded their positive and negative emotions in daily life 9 times a day for 6 consecutive days using smartphones, completed a depression questionnaire, and were genotyped for the 5-HTTLPR polymorphism. Carriers of the short 5-HTTLPR were characterized by higher inertia for negative emotions, even after controlling for depressive symptoms. These findings suggest a possible psychological pathway how the serotonin transporter gene contributes to risk for depression. (PsycINFO Database Record

Original languageEnglish
Pages (from-to)229-236
JournalEmotion
Volume18
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • emotional inertia
  • 5-HTTLPR
  • depression
  • experience sampling method
  • endophenotype
  • MAJOR DEPRESSIVE DISORDER
  • GENE-ENVIRONMENT INTERACTION
  • INDIVIDUAL-DIFFERENCES
  • ADOLESCENT DEPRESSION
  • METAANALYSIS
  • REACTIVITY
  • ASSOCIATION
  • EXPERIENCE
  • INSTABILITY
  • ANXIETY

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