Very-low-frequency oscillations of cerebral hemodynamics and blood pressure are affected by aging and cognitive load

Anouk Vermeij*, Aisha S. S. Meel-van den Abeelen, Roy P. C. Kessels, Arenda H. E. A. van Beek, Jurgen A. H. R. Claassen

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Spontaneous slow oscillations occur in cerebral hemodynamics and blood pressure (BP), and may reflect neurogenic, metabolic or myogenic control of the cerebral vasculature. Aging is accompanied by a degeneration of the vascular system, which may have consequences for regional cerebral blood flow and cognitive performance. This degeneration may be reflected in a reduction of spontaneous slow oscillations of cerebral hemodynamics and BP. Therefore, we aimed to establish the dependency of slow oscillations of cerebral hemodynamics and BP on the factors age and cognitive load, by using functional near-infrared spectroscopy (fNIRS). Fourteen healthy young (23-32 years) and 14 healthy older adults (64-78 years) performed a verbal n-back working-memory task. Oxygenated and deoxygenated hemoglobin concentration changes were registered by two fNIRS channels located over left and right prefrontal cortex. BP was measured in the finger by photoplethysmography. We found that very-low-frequency oscillations (0.02-0.07 Hz) and low-frequency oscillations (0.07-02 Hz) of cerebral hemodynamics and BP were reduced in the older adults compared to the young during task performance. In young adults, very-low-frequency oscillations of cerebral hemodynamics and BP reduced with increased cognitive load. Cognitive load did not affect low-frequency oscillations of the cerebral hemodynamics and BP. Transfer function analysis indicated that the relationship between BP and cerebral hemodynamic oscillations does not change under influence of age and cognitive load. Our results suggest aging-related changes in the microvasculature such as declined spontaneous activity in microvascular smooth muscle cells and vessel stiffness. Moreover, our results indicate that in addition to local vasoregulatory processes, systemic processes also influence cerebral hemodynamic signals. It is therefore crucial to take the factors age and BP into consideration for the analysis and interpretation of hemodynamic neuroimaging data. (C) 2013 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)608-615
JournalNeuroimage
Volume85
DOIs
Publication statusPublished - 15 Jan 2014
Externally publishedYes

Keywords

  • BOLD
  • Cerebral autoregulation
  • Near infrared spectroscopy
  • Spontaneous oscillations
  • Vasomotion
  • Working memory
  • NEAR-INFRARED SPECTROSCOPY
  • SPONTANEOUS FLUCTUATIONS
  • FUNCTIONAL ACTIVATION
  • ALZHEIMERS-DISEASE
  • BRAIN ACTIVITY
  • FRONTAL-LOBE
  • TOPOGRAPHY
  • AUTOREGULATION
  • METHODOLOGY
  • VASOMOTION

Cite this

Vermeij, A., Meel-van den Abeelen, A. S. S., Kessels, R. P. C., van Beek, A. H. E. A., & Claassen, J. A. H. R. (2014). Very-low-frequency oscillations of cerebral hemodynamics and blood pressure are affected by aging and cognitive load. Neuroimage, 85, 608-615. https://doi.org/10.1016/j.neuroimage.2013.04.107
Vermeij, Anouk ; Meel-van den Abeelen, Aisha S. S. ; Kessels, Roy P. C. ; van Beek, Arenda H. E. A. ; Claassen, Jurgen A. H. R. / Very-low-frequency oscillations of cerebral hemodynamics and blood pressure are affected by aging and cognitive load. In: Neuroimage. 2014 ; Vol. 85. pp. 608-615.
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Very-low-frequency oscillations of cerebral hemodynamics and blood pressure are affected by aging and cognitive load. / Vermeij, Anouk; Meel-van den Abeelen, Aisha S. S.; Kessels, Roy P. C.; van Beek, Arenda H. E. A.; Claassen, Jurgen A. H. R.

In: Neuroimage, Vol. 85, 15.01.2014, p. 608-615.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Very-low-frequency oscillations of cerebral hemodynamics and blood pressure are affected by aging and cognitive load

AU - Vermeij, Anouk

AU - Meel-van den Abeelen, Aisha S. S.

AU - Kessels, Roy P. C.

AU - van Beek, Arenda H. E. A.

AU - Claassen, Jurgen A. H. R.

PY - 2014/1/15

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N2 - Spontaneous slow oscillations occur in cerebral hemodynamics and blood pressure (BP), and may reflect neurogenic, metabolic or myogenic control of the cerebral vasculature. Aging is accompanied by a degeneration of the vascular system, which may have consequences for regional cerebral blood flow and cognitive performance. This degeneration may be reflected in a reduction of spontaneous slow oscillations of cerebral hemodynamics and BP. Therefore, we aimed to establish the dependency of slow oscillations of cerebral hemodynamics and BP on the factors age and cognitive load, by using functional near-infrared spectroscopy (fNIRS). Fourteen healthy young (23-32 years) and 14 healthy older adults (64-78 years) performed a verbal n-back working-memory task. Oxygenated and deoxygenated hemoglobin concentration changes were registered by two fNIRS channels located over left and right prefrontal cortex. BP was measured in the finger by photoplethysmography. We found that very-low-frequency oscillations (0.02-0.07 Hz) and low-frequency oscillations (0.07-02 Hz) of cerebral hemodynamics and BP were reduced in the older adults compared to the young during task performance. In young adults, very-low-frequency oscillations of cerebral hemodynamics and BP reduced with increased cognitive load. Cognitive load did not affect low-frequency oscillations of the cerebral hemodynamics and BP. Transfer function analysis indicated that the relationship between BP and cerebral hemodynamic oscillations does not change under influence of age and cognitive load. Our results suggest aging-related changes in the microvasculature such as declined spontaneous activity in microvascular smooth muscle cells and vessel stiffness. Moreover, our results indicate that in addition to local vasoregulatory processes, systemic processes also influence cerebral hemodynamic signals. It is therefore crucial to take the factors age and BP into consideration for the analysis and interpretation of hemodynamic neuroimaging data. (C) 2013 Elsevier Inc. All rights reserved.

AB - Spontaneous slow oscillations occur in cerebral hemodynamics and blood pressure (BP), and may reflect neurogenic, metabolic or myogenic control of the cerebral vasculature. Aging is accompanied by a degeneration of the vascular system, which may have consequences for regional cerebral blood flow and cognitive performance. This degeneration may be reflected in a reduction of spontaneous slow oscillations of cerebral hemodynamics and BP. Therefore, we aimed to establish the dependency of slow oscillations of cerebral hemodynamics and BP on the factors age and cognitive load, by using functional near-infrared spectroscopy (fNIRS). Fourteen healthy young (23-32 years) and 14 healthy older adults (64-78 years) performed a verbal n-back working-memory task. Oxygenated and deoxygenated hemoglobin concentration changes were registered by two fNIRS channels located over left and right prefrontal cortex. BP was measured in the finger by photoplethysmography. We found that very-low-frequency oscillations (0.02-0.07 Hz) and low-frequency oscillations (0.07-02 Hz) of cerebral hemodynamics and BP were reduced in the older adults compared to the young during task performance. In young adults, very-low-frequency oscillations of cerebral hemodynamics and BP reduced with increased cognitive load. Cognitive load did not affect low-frequency oscillations of the cerebral hemodynamics and BP. Transfer function analysis indicated that the relationship between BP and cerebral hemodynamic oscillations does not change under influence of age and cognitive load. Our results suggest aging-related changes in the microvasculature such as declined spontaneous activity in microvascular smooth muscle cells and vessel stiffness. Moreover, our results indicate that in addition to local vasoregulatory processes, systemic processes also influence cerebral hemodynamic signals. It is therefore crucial to take the factors age and BP into consideration for the analysis and interpretation of hemodynamic neuroimaging data. (C) 2013 Elsevier Inc. All rights reserved.

KW - BOLD

KW - Cerebral autoregulation

KW - Near infrared spectroscopy

KW - Spontaneous oscillations

KW - Vasomotion

KW - Working memory

KW - NEAR-INFRARED SPECTROSCOPY

KW - SPONTANEOUS FLUCTUATIONS

KW - FUNCTIONAL ACTIVATION

KW - ALZHEIMERS-DISEASE

KW - BRAIN ACTIVITY

KW - FRONTAL-LOBE

KW - TOPOGRAPHY

KW - AUTOREGULATION

KW - METHODOLOGY

KW - VASOMOTION

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DO - 10.1016/j.neuroimage.2013.04.107

M3 - Article

VL - 85

SP - 608

EP - 615

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

ER -