Whole dairy matrix or single nutrients in assessment of health effects: Current evidence and knowledge gaps

Tanja Kongerslev Thorning, Hanne Christine Bertram, Jean-philippe Bonjour, Lisette De Groot, Didier Dupont, Emma Feeney, Richard Ipsen, Jean Michel Lecerf, Alan Mackie, Michelle C Mckinley, Marie-caroline Michalski, Didier Rémond, Ulf Risérus, S.S. Soedamah-muthu, Tine Tholstrup, Connie Weaver, Arne Astrup, Ian Givens

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Foods consist of a large number of different nutrients that are contained in a complex structure. The nature of the food structure and the nutrients therein (i.e., the food matrix) will determine the nutrient digestion and absorption, thereby altering the overall nutritional properties of the food. Thus, the food matrix may exhibit a different relation with health indicators compared to single nutrients studied in isolation. The evidence for a dairy matrix effect was presented and discussed by an expert panel at a closed workshop, and the following consensus was reached: 1) Current evidence does not support a positive association between intake of dairy products and risk of cardiovascular disease (i.e., stroke and coronary heart disease) and type 2 diabetes. In contrast, fermented dairy products, such as cheese and yogurt, generally show inverse associations. 2) Intervention studies have indicated that the metabolic effects of whole dairy may be different than those of single dairy constituents when considering the effects on body weight, cardiometabolic disease risk, and bone health. 3) Different dairy products seem to be distinctly linked to health effects and disease risk markers. 4) Different dairy structures and common processing methods may enhance interactions between nutrients in the dairy matrix, which may modify the metabolic effects of dairy consumption. 5) In conclusion, the nutritional values of dairy products should not be considered equivalent to their nutrient contents but, rather, be considered on the basis of the biofunctionality of the nutrients within dairy food structures. 6) Further research on the health effects of whole dairy foods is warranted alongside the more traditional approach of studying the health effects of single nutrients. Future diet assessments and recommendations should carefully consider the evidence of the effects of whole foods alongside the evidence of the effects of individual nutrients. Current knowledge gaps and recommendations for priorities in future research on dairy were identified and presented

Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps (PDF Download Available). Available from: https://www.researchgate.net/publication/316112054_Whole_dairy_matrix_or_single_nutrients_in_assessment_of_health_effects_current_evidence_and_knowledge_gaps [accessed Dec 15 2017].
Original languageEnglish
Pages (from-to)1033-1045
JournalAmerican Journal of Clinical Nutrition
Volume105
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Fingerprint

Consensus Development Conferences
Yogurt
Cheese
Type 2 Diabetes Mellitus

Cite this

Thorning, T. K., Bertram, H. C., Bonjour, J., De Groot, L., Dupont, D., Feeney, E., ... Givens, I. (2017). Whole dairy matrix or single nutrients in assessment of health effects: Current evidence and knowledge gaps. American Journal of Clinical Nutrition, 105(5), 1033-1045. https://doi.org/10.3945/ajcn.116.151548
Thorning, Tanja Kongerslev ; Bertram, Hanne Christine ; Bonjour, Jean-philippe ; De Groot, Lisette ; Dupont, Didier ; Feeney, Emma ; Ipsen, Richard ; Lecerf, Jean Michel ; Mackie, Alan ; Mckinley, Michelle C ; Michalski, Marie-caroline ; Rémond, Didier ; Risérus, Ulf ; Soedamah-muthu, S.S. ; Tholstrup, Tine ; Weaver, Connie ; Astrup, Arne ; Givens, Ian. / Whole dairy matrix or single nutrients in assessment of health effects : Current evidence and knowledge gaps. In: American Journal of Clinical Nutrition. 2017 ; Vol. 105, No. 5. pp. 1033-1045.
@article{087775e4238c4edcbf0f54e1110184e5,
title = "Whole dairy matrix or single nutrients in assessment of health effects: Current evidence and knowledge gaps",
abstract = "Foods consist of a large number of different nutrients that are contained in a complex structure. The nature of the food structure and the nutrients therein (i.e., the food matrix) will determine the nutrient digestion and absorption, thereby altering the overall nutritional properties of the food. Thus, the food matrix may exhibit a different relation with health indicators compared to single nutrients studied in isolation. The evidence for a dairy matrix effect was presented and discussed by an expert panel at a closed workshop, and the following consensus was reached: 1) Current evidence does not support a positive association between intake of dairy products and risk of cardiovascular disease (i.e., stroke and coronary heart disease) and type 2 diabetes. In contrast, fermented dairy products, such as cheese and yogurt, generally show inverse associations. 2) Intervention studies have indicated that the metabolic effects of whole dairy may be different than those of single dairy constituents when considering the effects on body weight, cardiometabolic disease risk, and bone health. 3) Different dairy products seem to be distinctly linked to health effects and disease risk markers. 4) Different dairy structures and common processing methods may enhance interactions between nutrients in the dairy matrix, which may modify the metabolic effects of dairy consumption. 5) In conclusion, the nutritional values of dairy products should not be considered equivalent to their nutrient contents but, rather, be considered on the basis of the biofunctionality of the nutrients within dairy food structures. 6) Further research on the health effects of whole dairy foods is warranted alongside the more traditional approach of studying the health effects of single nutrients. Future diet assessments and recommendations should carefully consider the evidence of the effects of whole foods alongside the evidence of the effects of individual nutrients. Current knowledge gaps and recommendations for priorities in future research on dairy were identified and presented Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps (PDF Download Available). Available from: https://www.researchgate.net/publication/316112054_Whole_dairy_matrix_or_single_nutrients_in_assessment_of_health_effects_current_evidence_and_knowledge_gaps [accessed Dec 15 2017].",
author = "Thorning, {Tanja Kongerslev} and Bertram, {Hanne Christine} and Jean-philippe Bonjour and {De Groot}, Lisette and Didier Dupont and Emma Feeney and Richard Ipsen and Lecerf, {Jean Michel} and Alan Mackie and Mckinley, {Michelle C} and Marie-caroline Michalski and Didier R{\'e}mond and Ulf Ris{\'e}rus and S.S. Soedamah-muthu and Tine Tholstrup and Connie Weaver and Arne Astrup and Ian Givens",
year = "2017",
month = "5",
day = "1",
doi = "10.3945/ajcn.116.151548",
language = "English",
volume = "105",
pages = "1033--1045",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

Thorning, TK, Bertram, HC, Bonjour, J, De Groot, L, Dupont, D, Feeney, E, Ipsen, R, Lecerf, JM, Mackie, A, Mckinley, MC, Michalski, M, Rémond, D, Risérus, U, Soedamah-muthu, SS, Tholstrup, T, Weaver, C, Astrup, A & Givens, I 2017, 'Whole dairy matrix or single nutrients in assessment of health effects: Current evidence and knowledge gaps', American Journal of Clinical Nutrition, vol. 105, no. 5, pp. 1033-1045. https://doi.org/10.3945/ajcn.116.151548

Whole dairy matrix or single nutrients in assessment of health effects : Current evidence and knowledge gaps. / Thorning, Tanja Kongerslev; Bertram, Hanne Christine; Bonjour, Jean-philippe; De Groot, Lisette; Dupont, Didier; Feeney, Emma; Ipsen, Richard; Lecerf, Jean Michel; Mackie, Alan; Mckinley, Michelle C; Michalski, Marie-caroline; Rémond, Didier; Risérus, Ulf; Soedamah-muthu, S.S.; Tholstrup, Tine; Weaver, Connie; Astrup, Arne; Givens, Ian.

In: American Journal of Clinical Nutrition, Vol. 105, No. 5, 01.05.2017, p. 1033-1045.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Whole dairy matrix or single nutrients in assessment of health effects

T2 - Current evidence and knowledge gaps

AU - Thorning, Tanja Kongerslev

AU - Bertram, Hanne Christine

AU - Bonjour, Jean-philippe

AU - De Groot, Lisette

AU - Dupont, Didier

AU - Feeney, Emma

AU - Ipsen, Richard

AU - Lecerf, Jean Michel

AU - Mackie, Alan

AU - Mckinley, Michelle C

AU - Michalski, Marie-caroline

AU - Rémond, Didier

AU - Risérus, Ulf

AU - Soedamah-muthu, S.S.

AU - Tholstrup, Tine

AU - Weaver, Connie

AU - Astrup, Arne

AU - Givens, Ian

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Foods consist of a large number of different nutrients that are contained in a complex structure. The nature of the food structure and the nutrients therein (i.e., the food matrix) will determine the nutrient digestion and absorption, thereby altering the overall nutritional properties of the food. Thus, the food matrix may exhibit a different relation with health indicators compared to single nutrients studied in isolation. The evidence for a dairy matrix effect was presented and discussed by an expert panel at a closed workshop, and the following consensus was reached: 1) Current evidence does not support a positive association between intake of dairy products and risk of cardiovascular disease (i.e., stroke and coronary heart disease) and type 2 diabetes. In contrast, fermented dairy products, such as cheese and yogurt, generally show inverse associations. 2) Intervention studies have indicated that the metabolic effects of whole dairy may be different than those of single dairy constituents when considering the effects on body weight, cardiometabolic disease risk, and bone health. 3) Different dairy products seem to be distinctly linked to health effects and disease risk markers. 4) Different dairy structures and common processing methods may enhance interactions between nutrients in the dairy matrix, which may modify the metabolic effects of dairy consumption. 5) In conclusion, the nutritional values of dairy products should not be considered equivalent to their nutrient contents but, rather, be considered on the basis of the biofunctionality of the nutrients within dairy food structures. 6) Further research on the health effects of whole dairy foods is warranted alongside the more traditional approach of studying the health effects of single nutrients. Future diet assessments and recommendations should carefully consider the evidence of the effects of whole foods alongside the evidence of the effects of individual nutrients. Current knowledge gaps and recommendations for priorities in future research on dairy were identified and presented Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps (PDF Download Available). Available from: https://www.researchgate.net/publication/316112054_Whole_dairy_matrix_or_single_nutrients_in_assessment_of_health_effects_current_evidence_and_knowledge_gaps [accessed Dec 15 2017].

AB - Foods consist of a large number of different nutrients that are contained in a complex structure. The nature of the food structure and the nutrients therein (i.e., the food matrix) will determine the nutrient digestion and absorption, thereby altering the overall nutritional properties of the food. Thus, the food matrix may exhibit a different relation with health indicators compared to single nutrients studied in isolation. The evidence for a dairy matrix effect was presented and discussed by an expert panel at a closed workshop, and the following consensus was reached: 1) Current evidence does not support a positive association between intake of dairy products and risk of cardiovascular disease (i.e., stroke and coronary heart disease) and type 2 diabetes. In contrast, fermented dairy products, such as cheese and yogurt, generally show inverse associations. 2) Intervention studies have indicated that the metabolic effects of whole dairy may be different than those of single dairy constituents when considering the effects on body weight, cardiometabolic disease risk, and bone health. 3) Different dairy products seem to be distinctly linked to health effects and disease risk markers. 4) Different dairy structures and common processing methods may enhance interactions between nutrients in the dairy matrix, which may modify the metabolic effects of dairy consumption. 5) In conclusion, the nutritional values of dairy products should not be considered equivalent to their nutrient contents but, rather, be considered on the basis of the biofunctionality of the nutrients within dairy food structures. 6) Further research on the health effects of whole dairy foods is warranted alongside the more traditional approach of studying the health effects of single nutrients. Future diet assessments and recommendations should carefully consider the evidence of the effects of whole foods alongside the evidence of the effects of individual nutrients. Current knowledge gaps and recommendations for priorities in future research on dairy were identified and presented Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps (PDF Download Available). Available from: https://www.researchgate.net/publication/316112054_Whole_dairy_matrix_or_single_nutrients_in_assessment_of_health_effects_current_evidence_and_knowledge_gaps [accessed Dec 15 2017].

U2 - 10.3945/ajcn.116.151548

DO - 10.3945/ajcn.116.151548

M3 - Article

VL - 105

SP - 1033

EP - 1045

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -