Working memory plasticity modulated by dopamine transporter genotype

Yvonne Brehmer, Helena Westerberg, Martin Bellander, Daniel Fürth, Sari Karlsson, Lars Bäckman

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores.
Original languageEnglish
Pages (from-to)117-120
JournalNeuroscience Letters
Volume467
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Dopamine Plasma Membrane Transport Proteins
Short-Term Memory
Young Adult
Alleles

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Brehmer, Y., Westerberg, H., Bellander, M., Fürth, D., Karlsson, S., & Bäckman, L. (2009). Working memory plasticity modulated by dopamine transporter genotype. Neuroscience Letters, 467(2), 117-120. https://doi.org/10.1016/j.neulet.2009.10.018
Brehmer, Yvonne ; Westerberg, Helena ; Bellander, Martin ; Fürth, Daniel ; Karlsson, Sari ; Bäckman, Lars. / Working memory plasticity modulated by dopamine transporter genotype. In: Neuroscience Letters. 2009 ; Vol. 467, No. 2. pp. 117-120.
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Brehmer, Y, Westerberg, H, Bellander, M, Fürth, D, Karlsson, S & Bäckman, L 2009, 'Working memory plasticity modulated by dopamine transporter genotype', Neuroscience Letters, vol. 467, no. 2, pp. 117-120. https://doi.org/10.1016/j.neulet.2009.10.018

Working memory plasticity modulated by dopamine transporter genotype. / Brehmer, Yvonne; Westerberg, Helena; Bellander, Martin; Fürth, Daniel; Karlsson, Sari; Bäckman, Lars.

In: Neuroscience Letters, Vol. 467, No. 2, 2009, p. 117-120.

Research output: Contribution to journalArticleScientificpeer-review

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